Quantifying the impact of biobanks and cohort studies

• 成果类型: Article
• 署名作者: Dorantes-Gilardi, Rodrigo; Ivey, Kerry L.; Costa, Lauren; Matty, Rachael; Cho, Kelly; Gaziano, John Michael; Barabasi, Albert-Laszlo
• 署名单位: Harvard University; Harvard University Medical Affiliates; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Boston Healthcare System; Northeastern University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-9212
• DOI: 10.1073/pnas.2427157122
• 发表日期: 2025-04-22
• 关键词: disease; RISK; sustainability

摘要

Biobanks advance biomedical and clinical research by collecting and offering data and biological samples for numerous studies. However, the impact of these repositories varies greatly due to differences in their purpose, scope, governance, and data collected. Here, we computationally identified 2,663 biobanks and their textual mentions in 228,761 scientific articles, 16,210 grants, 15,469 patents, 1,769 clinical trials, and 9,468 public policy documents, helping characterize the academic communities that utilize and support them. We found a strong concentration of biobank-related research on a few diseases, including obesity, Alzheimer's disease, breast cancer, and diabetes. Moreover, collaboration, rather than citation count, shapes the community's recognition of a biobank. We show that, on average, 41.1% of articles fail to reference any of the biobank's reference papers, but 59.6% include a biobank member as a coauthor. Using a generalized linear model, we identified the key factors that contribute to the impact of a biobank, finding that an impactful biobank tends to be more open to external researchers and that quality data-especially linked medical records-as opposed to large data, correlates with a higher impact in science, innovation, and disease. The collected data and findings are accessible through an open-access web application intended to inform strategies to expand access and maximize the value of these resources.