16期

最新文章

• Tearing down the house of mosquito- transmitted viruses AI翻译
  作者：Pandey, Shanti; Gack, Michaela U.
  作者单位：Cleveland Clinic Foundation
• Primed 3D injectable microniches enabling low-dosage cell therapy for critical limb ischemia (vol 111, pg 13511, 2014) AI翻译
  作者：Li, Yaqian; Liu, Wei; Liu, Fei; Zeng, Yang; Zuo, Simin; Feng, Siyu; Qi, Chunxiao; Wang, Bingjie; Yan, Xiaojun; Khademhosseini, Ali; Bai, Jing; Du, Yanan
• The multifaceted roles of the transcriptional coactivator TAZ in extravillous trophoblast development of the human placenta AI翻译
  作者：Meinhardt, Gudrun; Waldhaeusl, Hanna; Lackner, Andreas I.; Waechter, Jasmin; Maxian, Theresa; Hoebler, Anna-Lena; Vondra, Sigrid; Kunihs, Victoria; Saleh, Leila; Haslinger, Peter; Kiraly, Peter; Szilagyi, Andras; Than, Nandor G.; Pollheimer, Juergen; Haider, Sandra; Knoefler, Martin
  作者单位：Medical University of Vienna; University Hospital Vienna; Medical University of Vienna; University Hospital Vienna; Semmelweis University
  摘要：Insights into the molecular processes that drive early development of the human placenta is crucial for our understanding of pregnancy complications such as preeclampsia and fetal growth restriction, since defects in maturation of its epithelial cell, the trophoblast, have been detected in the severe forms of these diseases. However, key regulators specifying the differentiated trophoblast subtypes of the placenta are only slowly emerging. By using diverse trophoblast cell models, we herein sh...
• European Neolithic farmers interbred their domestic pigs with wild boar AI翻译
  作者：Rowley-Conwy, Peter
  作者单位：Durham University
• Cleavage cascade of the sigma regulator FecR orchestrates TonB- dependent signal transduction AI翻译
  作者：Yokoyama, Tatsuhiko; Miyazaki, Ryoji; Suzuki, Takehiro; Dohmae, Naoshi; Nagai, Hiroki; Tsukazaki, Tomoya; Kubori, Tomoko; Akiyama, Yoshinori
  作者单位：Gifu University; Nara Institute of Science & Technology; RIKEN; Gifu University; Kyoto University
  摘要：TonB-dependent signal transduction is a versatile mechanism observed in gram-negative bacteria that integrates energy-dependent substrate transport with signal relay. In Escherichia coli, the TonB-ExbBD motor complex energizes the TonB-dependent outer membrane transporter FecA, facilitating ferric citrate import. FecA also acts as a sensor, transmitting signals to the cytoplasmic membrane protein FecR, which eventually activates the cytoplasmic sigma factor FecI, driving transcription of the f...
• The evolution of robustness and fragility during long- term bacterial adaptation AI翻译
  作者：Chihoub, Doha; Pintard, Coralie; Lenski, Richard E.; Tenaillon, Olivier; Couce, Alejandro
  作者单位：Universidad Politecnica de Madrid; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Michigan State University; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：Theory predicts that well-adapted populations may evolve mechanisms to counteract the inevitable influx of deleterious mutations. While mutational robustness can be directly selected in the laboratory, evidence for its spontaneous evolution during general adaptation is mixed. Moreover, whether robustness evolves to include pleiotropic effects remains largely unexplored. Here, we studied the effects of point mutations in the RNA polymerase of Escherichia coli over a 15,000-generation adaptive t...
• Inhibitory control explains locomotor statistics in walking Drosophila AI翻译
  作者：Gattuso, Hannah C.; van Hassel, Karin A.; Freed, Jacob D.; Nunez, Kavin M.; de la Rea, Beatriz; May, Christina E.; Ermentrout, Bard; Victor, Jonathan D.; Nagel, Katherine I.
  作者单位：New York University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Cornell University; Weill Cornell Medicine
  摘要：In order to forage for food, many animals regulate not only specific limb movements but the statistics of locomotor behavior, switching between long-range dispersal and local search depending on resource availability.How premotor circuits regulate locomotor statistics is not clear. Here, we analyze and model locomotor statistics and their modulation by attractive food odor in walking Drosophila. Food odor evokes three motor regimes in flies: baseline walking, upwind running during odor, and se...
• Housing inequality and settlement persistence are associated across the archaeological record AI翻译
  作者：Lawrence, Dan; Bogaard, Amy; Quequezana, Gabriela Cervantes; Chelazzi, Francesca; Feinman, Gary M.; Green, Adam S.; Hamerow, Helena; Munson, Jessica; Ortman, Scott G.; Thompson, Amy E.
  作者单位：Durham University; University of Oxford; The Santa Fe Institute; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Universita Ca Foscari Venezia; Field Museum of Natural History (Chicago); University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of York - UK; University of York - UK; University of Colorado System; University of Colorado Boulder; University of Texas System; University of Texas Austin
  摘要：Definitions of sustainability commonly stress both systemic continuity and equality over time. However, the degree to which these two sides of sustainability might be related has not been systematically investigated. Recent theoretical and methodological insights have provided archaeologists with new tools for investigating sustainability in premodern societies. Here, we use Gini coefficients on residence size measurements as an estimate of material inequality and information on the persistenc...
• An integrated mechanism of regulation of PLCβ enzymes AI翻译
  作者：Senarath, Kanishka; Fisher, Isaac J.; Jang, Wonjo; Lu, Sumin; Inoue, Asuka; Kostenis, Evi; Lyon, Angeline M.; Lambert, Nevin A.
  作者单位：University System of Georgia; Augusta University; Purdue University System; Purdue University; Tohoku University; Kyoto University; University of Bonn; Purdue University System; Purdue University
  摘要：Phospholipase C beta (PLC beta) enzymes are the principal effectors activated by Gq heterotrimers. Both G alpha q and G beta gamma subunits can activate PLC beta, which requires precise positioning of PLC beta at the plasma membrane to relieve structural autoinhibition and give the active site access to the phosphatidylinositol 4,5-bisphosphate (PIP2) substrate. PLC beta enzymes possess a unique distal C-terminal domain (dCTD) that is critical for activation by G alpha q, but the reason for th...
• The emergence and loss of cyclic peptides in Nicotiana illuminate dynamics and mechanisms of plant metabolic evolution AI翻译
  作者：Suh, Elliot M.; Reinhardt, Jakob K.; Weng, Jing-Ke; Baldwin, Ian
  作者单位：Northeastern University; Northeastern University; Northeastern University; Northeastern University
  摘要：Specialized metabolism plays a central role in how plants cope with both biotic and abiotic stresses in order to survive and reproduce within dynamic and challenging environments. One recently described class of plant-specific, ribosomally synthesized, and posttranslationally modified peptides are the burpitides, which are characterized by the installation of distinct sidechain macrocycles by enzymes known as burpitide cyclases. While they are found across many plant families and exhibit diver...