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作者：Zhao, Xianxin; Liu, Yuanyuan; Yuan, Bo; Cao, Zhichao; Yang, Yi; He, Chun; Chan, Kevin C.; Xiao, Shan; Lin, Haiwei; Fang, Qi; Ye, Gongyin; Ye, Xinhai
作者单位：Zhejiang University; Zhejiang University; Xi'an Jiaotong-Liverpool University; Zhejiang University; Zhejiang A&F University; Zhejiang A&F University
摘要：Trait regression and loss have occurred repeatedly in numerous lineages in response to environmental changes. In parasitoid wasps, a megadiverse group of hymenopteran insects, yolk protein reduction or loss has been observed in many species, likely linked to the transition from ectoparasitism to endoparasitism. However, the genetic basis of this trait and the impact of its loss on genome evolution remain poorly understood. Here, we performed a comparative genomic analysis of 64 hymenopteran in...
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作者：Chen, Yu-Fei; Zhang, Qing-Hua; Zhang, Zhong-Wei; Zhou, Yu-Jie; Liu, Cui-Cui; Shao, Zhi-Ming; Yu, Ke-Da
作者单位：Fudan University; Fudan University; Fudan University
摘要：Antibody-drug conjugates (ADCs) are a rapidly developing therapeutic approach in cancer treatment that has shown remarkable efficacy in breast cancer. Despite the promising efficacy of anti-HER2 ADCs, many patients are still experiencing disease progression under treatment. Here, by analyzing the transcriptome data from patient-derived organoid models, I-SPY2 trial, and resistant cell lines, we identified that SNX10 deficiency conferred anti-HER2 ADCs resistance in HER2-positive breast cancer....
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作者：Hatori, Sena; Yamaguchi, Sho T.; Kobayashi, Riho; Okamoto, Kazuki; Zhou, Zhiwen; Kotake, Koki T.; Matsui, Futaba; Hioki, Hiroyuki; Norimoto, Hiroaki
作者单位：Nagoya University; Hokkaido University; Juntendo University
摘要：Slow-wave sleep (SWS) and rapid eye movement sleep are the two primary components of electrophysiological sleep (e-sleep) in mammals and birds. Slow waves in the cortex not only characterize SWS but are also used as biological markers for sleep homeostasis, given their rebound after sleep deprivation (SD). Recently, it has been reported that the Australian dragon Pogona vitticeps exhibits a two-stage sleep pattern in the dorsal ventricular ridge (DVR), which includes a homologue of the mammali...
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作者：Moreno-Spiegelberg, Pablo; Rietkerk, Max; Gomila, Damia
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作者：Sahi, Chandan; Craig, Elizabeth Anne
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作者：Budeski, Katherine; Lipsitch, Marc
作者单位：Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard T.H. Chan School of Public Health
摘要：Preparing to rapidly respond to emerging infectious diseases is critical. SpillOver: Viral Risk Ranking is an open-source tool developed to assess the risk of novel wildlife-origin viruses spilling over from animals to humans and spreading in human populations. Several risk factors used by the tool depend on evidence of previous zoonotic spillover itself or sustained transmission in humans. Therefore, we reanalyzed the Ranking Comparison after removing eight of the 31 risk factors that require...
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作者：Carrasco, Maria Rios; Lin, Ting-Hui; Zhu, Xueyong; Garcia, Alba Gabarroca; Uslu, Elif; Liang, Ruonan; Spruit, Cindy M.; Richard, Mathilde; Boons, Geert-Jan; Wilson, Ian A.; de Vries, Robert P.
作者单位：Utrecht University; Scripps Research Institute; Erasmus University Rotterdam; Erasmus MC; University System of Georgia; University of Georgia; Scripps Research Institute
摘要：H5Nx viruses continue to wreak havoc in avian and mammalian species worldwide. The virus distinguishes itself by the ability to replicate to high titers and transmit efficiently in a wide variety of hosts in diverse climatic environments. Fortunately, transmission to and between humans is scarce. Yet, if such an event were to occur, it could spark a pandemic as humans are immunologically na & iuml;ve to H5 viruses. A significant determinant of transmission to and between humans is the ability ...
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作者：McClelland, James L.
摘要：The 2024 Nobel Prize in Physics recognizes breakthroughs contributing to the emergence of a new understanding of the computations that underlie human intelligence, with profound implications for artificially intelligent systems. John Hopfield and Geoffrey Hinton played seminal roles in these breakthroughs. I begin by characterizing the scientific context in which the new understanding of intelligence began to arise. I then consider Hopfield's and Hinton's ideas and their centrality in the scie...
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作者：Xiang, Sidney; Romero, Daniel M.; Teplitskiy, Misha
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
摘要：Interdisciplinary research is essential for addressing complex global challenges, but there are concerns that scientific institutions like journals select against it. Prior work has focused largely on how interdisciplinarity relates to outcomes for published papers, but which papers get accepted for publication in the first place is unclear. Furthermore, journals may evaluate two key dimensions of interdisciplinarity,-topic and knowledge base,-differently. Topic interdisciplinarity (measured t...
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作者：Awoyomi, Ololade Folajimi; Gorospe, Choco Michael; Das, Biswajit; Mishra, Pradeep; Sharma, Sushma; Diachenko, Olena; Nilsson, Anna Karin; Tran, Phong; Wanrooij, Paulina H.; Chabes, Andrei
作者单位：Umea University
摘要：Mitochondrial DNA (mtDNA) replication requires a steady supply of deoxyribonucleotides (dNTPs), synthesized de novo by ribonucleotide reductase (RNR). In non-dividing cells, RNR consists of RRM1 and RRM2B subunits. Mutations in RRM2B cause mtDNA depletion syndrome, linked to muscle weakness, neurological decline, and early mortality. The impact of RRM2B deficiency on dNTP pools in nondividing tissues remains unclear. Using a mouse knockout model, we demonstrate that RRM2B deficiency selectivel...
