18期

最新文章

• Decreased likelihood of schooling as a consequence of tropical cyclones: Evidence from 13 low-and middle-income countries AI翻译
  作者：Jing, Renzhi; Heft-Neal, Sam; Wang, Zetianyu; Chen, Jie; Qiu, Minghao; Opper, Isaac M.; Wagner, Zachary; Bendavid, Eran
  作者单位：Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; Stanford University; Stanford University; RAND Corporation; Princeton University; State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University; University of Southern California
  摘要：Increasing educational attainment is one of the most important and effective strategies for health and economic improvements. The extent to which extreme climate events disrupt education, resulting in reduced educational attainment, remains understudied. Children in low- and middle-income countries (LMICs) may be uniquely vulnerable to losing schooling after disasters due to the poor physical condition of schools and the lack of resources to mitigate unexpected household shocks. Our analysis a...
• Understanding TAK1 deficiency in microglia: Dual mechanisms for photoreceptor protection in a mouse model of retinitis pigmentosa AI翻译
  作者：Zhang, Jing; Yang, Wei; Wu, Jiangmei; Lin, Bin
  作者单位：Hong Kong Polytechnic University; Central South University; Hong Kong Polytechnic University
  摘要：Retinitis pigmentosa (RP) is a group of inherited retinal diseases characterized by the progressive loss of photoreceptors. Neuroinflammation has been implicated the pathophysiology of RP and its progression. Previous studies have suggested that the transforming growth factor-beta-activated kinase 1 (TAK1) plays a pivotal role in regulating acute and chronic neuroinflammation. However, the functional role of TAK1 neuroinflammation remains unclear in RP. Here, we observed TAK1 upregulation acti...
• 撤稿声明: Role of test motivation in intelligence testing AI翻译
  作者：Duckworth, Angela Lee; Quinn, Patrick D.; Lynam, Donald R.
• Nonproteolytic ubiquitination regulates chromatin occupancy by the NCoR/SMRT/HDAC3 corepressor complex in MCF-7 breast cancer cells AI翻译
  作者：Ferrero, Giulio; Cardamone, Maria Dafne; Luca, Francesca; Bourk, Eliot; Ricci, Laura; Liu, Wen; Gao, Yuan; Burrone, Giulia; Muhammad, Akhirah; Chan, Stefanie; Smith, Emma; Fan, Ting-Yu Claire; Cutrupi, Santina; Garcia -Bassets, Ivan; De Bortoli, Michele; Rosenfeld, Michael G.; Perissi, Valentina
  作者单位：University of Turin; Boston University; University of California System; University of California San Diego; University of Turin
  摘要：Tight regulation of gene expression is achieved through the coordinated action of transcription factors and cofactors that often can act as both repressors and activators in response to regulatory signals, with their activity modulated by context-specific signal transduction pathways that also impinge on their transient and cyclical recruitment to chromatin. However, the mechanisms underlying the intricate interplay between the regulatory strategies controlling cofactors' activity and localiza...
• Calcium-activated chloride channel TMEM16A opens via pi-helical transition in transmembrane segment 4 AI翻译
  作者：Kostritskii, Andrei Y.; Kostritskaia, Yulia; Dmitrieva, Natalia; Stauber, Tobias; Machtens, Jan-Philipp
  作者单位：Helmholtz Association; Julich Research Centre; MSH Medical School Hamburg; Hannover Medical School
  摘要：TMEM16A is a Ca2+-activated Cl-channel that has crucial roles in various physiological and pathological processes. However, the structure of the open state of the channel and the mechanism of Ca2+-induced pore opening have remained elusive. Using extensive molecular dynamics simulations, protein structure prediction, and patch-clamp electrophysiology, we demonstrate that TMEM16A opens a hydrated Cl--conductive pore via a pi-helical transition in transmembrane segment 4 (TM4). We also describe ...
• Accurate identification and mechanistic evaluation of pathogenic missense variants with Rhapsody- 2 AI翻译
  作者：Banerjee, Anupam; Bogetti, Anthony T.; Bahar, Ivet
  作者单位：State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University; Stony Brook University Hospital
  摘要：Understanding the effects of missense mutations or single amino acid variants (SAVs) on protein function is crucial for elucidating the molecular basis of diseases/disorders and designing rational therapies. We introduce here Rhapsody-2, a machine learning tool for discriminating pathogenic and neutral SAVs, significantly expanding on a precursor limited by the availability of structural data. With the advent of AlphaFold2 as a powerful tool for structure prediction, Rhapsody-2 is trained on a...
• Jellyfish shape as a mechanical balance (vol 122, e2412082122, 2025) AI翻译
  作者：Gong, Mengsha; Ashok, Minakshi; Helou, Ariane; Goentoro, Lea
• Quantification and potential functional relevance of binding cooperativity of adjacent transcription factors on DNA AI翻译
  作者：Wang, Xinyao; Xie, Chen; Shen, Ke; Li, Dubai; Xie, Xiaoliang Sunney
  作者单位：Peking University; Peking University; Changping Laboratory; Peking University
  摘要：In eukaryotes, the expression of specific genes is regulated by a combination of transcription factors (TFs) bound on regulatory regions of the genomic DNA (promoters and enhancers). Recent advances in genomic sequencing technology have enabled the measurements of TFs' footprints and binding affinities on DNA at the single-molecule level, facilitating the probing of binding cooperativity among adjacent TFs. This necessitates quantitative descriptions of TFs' binding cooperativity and understan...
• A hierarchy of processing complexity and timescales for natural sounds in the human auditory cortex AI翻译
  作者：Rupp, Kyle M.; Hect, Jasmine L.; Harford, Emily E.; Holt, Lori L.; Ghuman, Avniel Singh; Abel, Taylor J.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Texas System; University of Texas Austin; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：Efficient behavior is supported by humans' ability to rapidly recognize acoustically distinct sounds as members of a common category. Within the auditory cortex, critical unanswered questions remain regarding the organization and dynamics of sound categorization. We performed intracerebral recordings during epilepsy surgery evaluation as 20 patient-participants listened to natural sounds. We then built encoding models to predict neural responses using sound representations extracted from diffe...
• Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis AI翻译
  作者：Sakuma, Ikki; Gaspar, Rafael C.; Nasiri, Ali R.; Dufour, Sylvie; Kahn, Mario; Zheng, Jie; Lamoia, Traci E.; Guerra, Mateus T.; Taki, Yuki; Kawashima, Yusuke; Yimlamai, Dean; Perelis, Mark; Vatner, Daniel F.; Petersen, Kitt Falk; Huttasch, Maximilian; Knebel, Birgit; Kahl, Sabine; Roden, Michael; Samuel, Varman T.; Tanaka, Tomoaki; Shulman, Gerald I.
  作者单位：Yale University; Chiba University; Yale University; Ionis Pharmaceuticals, Inc.; Heinrich Heine University Dusseldorf; Leibniz Association; Deutsches Diabetes-Zentrum (DDZ); German Center for Diabetes Research (DZD); Leibniz Association; Heinrich Heine University Dusseldorf; Deutsches Diabetes-Zentrum (DDZ); Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf Hospital; Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf Hospital; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Connecticut Healthcare System; Yale University; Howard Hughes Medical Institute
  摘要：Metabolic dysfunction-associated steatohepatitis (MASH) represents a progressive form of steatotic liver disease which increases the risk for fibrosis and advanced liver disease. The accumulation of discrete species of bioactive lipids has been postulated to activate signaling pathways that promote inflammation and fibrosis. However, the key pathogenic lipid species is a matter of debate. We explored candidates using various dietary, molecular, and genetic models. Mice fed a choline-deficient ...