18期

最新文章

• Persistent inequalities in global air quality monitoring should not delay pollution mitigation AI翻译
  作者：Smith, Keith; Lauriere, Camille Fournier de; Henninger, Ella
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Air pollution is a global health crisis that disproportionately affects lower- and middle-income countries. We examine global air quality monitoring data, highlighting persistent inequalities in high-exposure regions, and assess the potential of emerging technologies to improve data utility for mitigation. Improving air quality, however, does not need to wait for more data, nor will monitoring alone drive action. Immediate mitigation measures with broad cobenefits are needed now to reduce poll...
• Total whole- arm chromosome losses predict malignancy in human cancer AI翻译
  作者：Zheng, Ye; Ahmad, Kami; Henikoff, Steven
  作者单位：Fred Hutchinson Cancer Center; Howard Hughes Medical Institute; University of Texas System; UTMD Anderson Cancer Center
  摘要：Aneuploidy is observed as gains or losses of whole chromosomes or chromosome arms and is a common hallmark of cancer. Whereas models for the generation of aneuploidy in cancer invoke mitotic chromosome segregation errors, whole-arm losses might occur simply as a result of centromere breakage. We recently showed that elevated RNA Polymerase II level over the S-phase-dependent histone genes predicts rapid recurrence of human meningioma and is correlated with total whole-arm losses relative to ga...
• Inhaled DNAI1 mRNA therapy for treatment of primary ciliary AI翻译
  作者：Hennig, Mirko; Bhattacharjee, Rumpa B.; Agarwal, Ishita; Alfaifi, Ali; Casillas, Jade E.; Chavez, Sofia; Ishimaru, Daniella; Liston, David; Mohapatra, Sakya; Molla, Touhidul; Pathare, Suyog; Sidhu, Maninder S.; Wang, Peng; Wang, Zechen; Lombana, T. Noelle; Kharitonov, Vladimir G.; Couch, Jessica A.; Lockhart, David J.; Wustman, Brandon A.
  摘要：Primary ciliary dyskinesia (PCD) is an autosomal recessive disorder caused by mutations in one of at least 50 different genes that encode proteins involved in the biogenesis, structure, or function of motile cilia. Genetically inherited defects in motile cilia cause PCD, a debilitating respiratory disease for which there is no approved therapy. The dynein axonemal intermediate chain 1 (DNAI1) protein is a key structural element of the ciliary outer dynein arm (ODA) critical for normal ciliary ...
• Mass- independent fractionation of oxygen isotopes during high- temperature condensation in cosmochemical plasmas AI翻译
  作者：Asset, Nathan; Chaussidon, Marc; Lombardi, Guillaume; Villeneuve, Johan; Tartese, Romain; Mostefaoui, Smail; Robert, Francois
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Universite de Lorraine; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); University of Manchester; Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite Paris Cite; CNRS - Institute of Physics (INP)
  摘要：Contrary to all terrestrial rocks, planets and meteorites exhibit oxygen isotope variations decorrelated with the mass difference of their atomic nuclei. It has been proposed that, in the protosolar nebula (PSN), these variations could result from mass independent isotopic fractionation (MIF) either during specific chemical reactions similar to those responsible for the formation of ozone in the Earth's atmosphere or during ultraviolet (UV)- photolysis of carbon monoxide (CO) gas in the PSN. H...
• Comparative single- cell analysis of transcriptional bursting reveals the role of genome organization in de novo transcript origination AI翻译
  作者：Lee, Unjin; Li, Cong; Langer, Christopher B.; Svetec, Nicolas; Zhao, Li
  作者单位：Rockefeller University
  摘要：Spermatogenesis is a key developmental process underlying the origination of newly evolved genes. However, rapid cell type-specific transcriptomic divergence of the Drosophila germline has posed a significant technical barrier for comparative single- cell RNA- sequencing studies. By quantifying a surprisingly strong correlation between species- and cell type-specific divergence in three closely related Drosophila species, we apply a statistical procedure to identify a core set of 198 genes tha...
• Toward quantitative X-ray elastography of coronary arteries using flexural pulse waves AI翻译
  作者：Gregoire, Sibylle; Laloy-Borgna, Gabrielle; Rouviere, Olivier; Giammarinaro, Bruno; Catheline, Stefan; Weitz, David
  作者单位：Universite Lyon 1; Institut National de la Sante et de la Recherche Medicale (Inserm); Delft University of Technology; Universite Lyon 1; CHU Lyon
  摘要：Dynamic elastography uses an imaging system to visualize the propagation of elastic waves, the speed of which is directly related to the elasticity felt by palpation. Very few studies have focused on X-ray elastography because of the technical challenges it poses: a planar image of an integration volume at a very slow sampling rate. We demonstrate that tracking a slow elastic wave guided along a one-dimensional structure could provide a possible solution. The recently discovered flexural pulse...
• Bacterial extracellular vesicles target different bacterial species, impairing cell division and diminishing their pathogenicity AI翻译
  作者：Kawagishi, Yu; Murase, Kazunori; Grebenshchikova, Anna; Iibushi, Junpei; Ma, Chang; Kimeu, Teresia M.; Minowa-Nozawa, Atsuko; Nozawa, Takashi; Nakagawa, Ichiro
  作者单位：Kyoto University; Japan Institute for Health Security (JIHS); National Institute of Infectious Diseases (NIID); Kyoto University
  摘要：Extracellular vesicles (EVs) produced by bacteria contain many bacterial-derived molecules, which play an important role in host interactions and as mediators of bacterial communication. However, the role of EVs in interspecies interactions and their physiological and ecological significance are not well understood. In this study, we found that Escherichia coli EVs inhibit the growth of group A Streptococcus (GAS; Streptococcus pyogenes) by inducing defective cell division via the following pr...
• Exposure and health risks of livestock air resistomes AI翻译
  作者：Sun, Wei; Wang, Jun; Wang, Guangdong; Jiang, Lan; Feng, Wenlu; Dang, Shuangsuo; Li, Mei; Jiao, Shuo; Wei, Gehong; Gu, Jie; Tiedje, James M.; Qian, Xun
  作者单位：Northwest A&F University - China; Northwest A&F University - China; Northwest A&F University - China; Xi'an Jiaotong University; Northwest A&F University - China; Michigan State University
  摘要：Most of the global antibiotic consumption is by the livestock industry, making livestock sure to workers, but the health risks of air resistomes remain unclear. We evaluated the human exposure and health risks of air resistomes in pig and chicken farms and compared air resistomes in Chinese farms to those in European farms given their long- term restrictions on use of antibiotics in livestock. We found that livestock air was highly enriched in ARGs, with each cell harboring seven times more AR...
• Four-million-year Marinoan snowball shows multiple routes to deglaciation AI翻译
  作者：Tasistro-Hart, Adrian R.; Macdonald, Francis A.; Crowley, James L.; Schmitz, Mark D.
  作者单位：University of California System; University of California Berkeley; Boise State University
  摘要：Twice during the Neoproterozoic Era, Earth experienced runaway ice-albedo catastrophes that resulted in multimillion year, low-latitude glaciations: the Sturtian and Marinoan snowball Earths. In the snowball climate state, CO2 consumption through silicate weathering collapses, and atmospheric CO2 accumulates via volcanic outgassing until a sufficiently strong greenhouse causes deglaciation. The duration and extent of ice cover are critical for planetary habitability, both on exoplanets and on ...
• Horizontal transfer of nuclear DNA in transmissible cancer AI翻译
  作者：Gori, Kevin; Baez-Ortega, Adrian; Strakova, Andrea; Stammnitz, Maximilian R.; Wang, Jinhong; Chan, Jonathan; Hughes, Katherine; Belkhir, Sophia; Hammel, Maurine; Moralli, Daniela; Bancroft, James; Drydale, Edward; Allum, Karen M.; Brignone, Maria Veronica; Corrigan, Anne M.; de Castro, Karina F.; Donelan, Edward M.; Faramade, Ibikunle A.; Hayes, Alison; Ignatenko, Nataliia; Karmacharya, Rockson; Koenig, Debbie; Lanza-Perea, Marta; Quintana, Adriana M. Lopez; Meyer, Michael; Neunzig, Winifred; Pedraza-Ordonez, Francisco; Phuentshok, Yoenten; Phuntsho, Karma; Ramirez-Ante, Juan C.; Reece, John F.; Schmeling, Sheila K.; Singh, Sanjay; Martinez, Lester J. Tapia; Taulescu, Marian; Thapa, Samir; Thapa, Sunil; van der Wel, Mirjam G.; Wehrle-Martineza, Alvaro S.; Stratton, Michael R.; Murchison, Elizabeth P.
  作者单位：University of Cambridge; Wellcome Trust Sanger Institute; University of Cambridge; University of Oxford; University of Oxford; University of Buenos Aires; Universidade Estadual Paulista; Universidad de Caldas; University of Agricultural Sciences & Veterinary Medicine Cluj Napoca; Universidad Nacional de Asuncion
  摘要：Horizontal transfer of nuclear DNA between cells of host and cancer is a potential source of adaptive variation in cancer cells. An understanding of the frequency and significance of this process in naturally occurring tumors is, however, lacking. We screened for this phenomenon in the transmissible cancers of dogs and Tasmanian devils and found an instance in the canine transmissible venereal tumor (CTVT). This involved introduction of a 15-megabase dicentric genetic element, composed of 11 f...