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作者：Granulo, Armin; Fuchs, Christoph; Boehm, Robert
作者单位：Technical University of Munich; University of Vienna; University of Vienna; University of Copenhagen; University of Copenhagen; University of Innsbruck
摘要：Governments need to develop and implement effective policies to address pressing societal problems of our time, such as climate change and global pandemics. While some policies focus on changing individual thoughts and behaviors (e.g., informational interventions, behavioral nudges), others involve systemic changes (e.g., car bans, vaccination mandates). Policymakers may use system-level policies to achieve socially desirable outcomes, yet often refrain from doing so because they anticipate pu...
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作者：Burns, Alon; Toker, Sharon; Berson, Yair; Gordon, Ilanit
作者单位：Bar Ilan University; Tel Aviv University; McMaster University; Bar Ilan University; Yale University
摘要：In a world where teams serve as the backbone of collaboration and innovation, women must feel safe when contributing to teamwork. Unfortunately, an increasing number of women report experiencing sexual harassment in workplaces and other collective settings. This research included an examination of how exposure to sexist insults affects collaborative efforts. We argue that in addition to its well- documented effects on individuals, sexism within teams undermines team performance. Hence, emotion...
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作者：Lenner, Nicolas; Chariker, Logan; Leibler, Stanislas
作者单位：Institute for Advanced Study - USA; Duke University; Rockefeller University
摘要：In the common cellular space, hundreds of binding reactions occur reliably and enable this remarkable compatibility have not yet been adequately elucidated. In order to delineate these principles, we consider the intracellular sensing of transition metals in bacteria-an integral part of cellular metal homeostasis. Protein cytosolic sensors typically interact with metals through three types of lateral chain residues, containing oxygen, nitrogen, or sulfur. The very existence of complete sets of...
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作者：Zhou, Yang; Sheng, Qiongyu; Jin, Shuilin
作者单位：Harbin Institute of Technology; Harbin Institute of Technology
摘要：Constructing single-cell atlases requires preserving differences attributable to biological variables, such as cell types, tissue origins, and disease states, while eliminating batch effects. However, existing methods are inadequate in explicitly modeling these biological variables. Here, we introduce SIGNAL, a general framework that leverages biological variables to disentangle biological and technical effects, thereby linking these metadata to data integration. SIGNAL employs a variant of pr...
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作者：Burcroff, Amanda; Lee, Kyungyong; Mou, Lang
作者单位：Harvard University; University of Alabama System; University of Alabama Tuscaloosa; Korea Institute for Advanced Study (KIAS); University of Cologne
摘要：In 2013, Lee, Li, and Zelevinsky introduced combinatorial objects called compatible pairs to construct the greedy bases for rank-2 cluster algebras, consisting of indecomposable positive elements including the cluster monomials. Subsequently, Rupel extended this construction to the setting of generalized rank-2 cluster algebras by defining compatible gradings. We find a class of combinatorial objects which we call tight gradings. Using this, we give a directly computable, manifestly positive, ...
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作者：Che, Yonglu; Lee, Jinwoo; Abou-Taleb, Farah; Rieger, Kerri E.; Satpathy, Ansuman T.; Chang, Anne Lynn S.; Chang, Howard Y.
作者单位：Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Howard Hughes Medical Institute
摘要：Immune checkpoint inhibitors such as anti-Programmed Death-1 antibodies (aPD-1) can be effective in treating advanced cancers. However, many patients do not respond, and the mechanisms underlying these differences remain incompletely understood. In this study, we profile a cohort of patients with locally advanced or metastatic basal cell carcinoma undergoing aPD-1 therapy using single-cell RNA sequencing, high-definition spatial transcriptomics in tumors and draining lymph nodes, and spatial i...
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作者：Drake, Abby Grace; Revell, Liam J.; Klingenberg, Christian Peter; Lattimer, Jimmy C.; Nelson, Nathan C.; Schmidt, Martin J.; Zwingenberger, Allison L.; Moyer, Joshua K.; Losos, Jonathan B.
作者单位：Cornell University; University of Massachusetts System; University of Massachusetts Boston; University of Manchester; University of Missouri System; University of Missouri Columbia; North Carolina State University; Justus Liebig University Giessen; University of California System; University of California Davis; Yale University; Washington University (WUSTL)
摘要：Many domesticated species exhibit remarkable phenotypic diversity. In nature, selection produces not only divergence but also convergence when organisms experience similar selective pressures. Whether artificial selection during domestication also produces convergence has received little attention. Three-dimensional shape analysis of domestic cat and dog skulls demonstrated convergence at multiple levels. Most broadly, cats and dogs have both diversified greatly: equaling or exceeding the morp...
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作者：Smith, Gregory P.; Zhu, Chenhui; Zernenkov, Mikail; Frechet, Guillaume; Clark, Noel A.
作者单位：University of Colorado System; University of Colorado Boulder; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Brookhaven National Laboratory
摘要：At high concentration, long Watson/Crick (WC) double-helixed DNA forms columnar crystal or liquid crystal phases of linear, parallel duplex chains packed on periodic lattices. This can also be a structural motif of short NA oligomers such as the 5'- GTAC-3' studied here, which makes four-base WC duplexes having hydrophobic blunt ends. End-to-end aggregation then assembles these duplexes into columns and columnar phases are stabilized, in spite of breaks in the double helix every four bases. Bu...
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作者：Tian, Debin; Li, Wen; Heffron, C. Lynn; Mahsoub, Hassan M.; Wang, Bo; LeRoith, Tanya; Meng, Xiang-Jin
作者单位：Virginia Polytechnic Institute & State University; Virginia Polytechnic Institute & State University
摘要：Hepatitis E virus (HEV) genotype 1 (HEV-1) infection in pregnant women is associated with adverse outcomes of pregnancy including fulminant hepatic failure, fetal loss, premature birth, and neonatal mortality, although the underlying mechanisms remain largely unclear. In this study, we first demonstrated that HEV-1 robustly infects pregnant gerbils and causes pregnancy-associated adverse outcomes, which were recorded in 4/6 HEV-1-infected but only 1/5 in PBS-inoculated pregnant gerbils. Howeve...
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作者：Wu, Jian; Tan, Jingqiang; Xu, Jinqi; Li, Lei; Beroza, Gregory C.; Mumford, Kevin G.; van de Ven, Cole; Chen, Baixi; Elsworth, Derek
作者单位：Central South University; University of Sydney; Central South University; Stanford University; Queens University - Canada; Carleton University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
摘要：China's shale gas production has grown annually by 21% since 2017 with long-term national energy strategy calling for continued expansion. This large-scale shale gas development is challenged by constraints on water supply. It requires over 6,000 new wells to be drilled within the Yangtze River Basin in South China-one of China's most populated regions with sensitive ecological and geological conditions, posing significant environmental threats to the hydrosphere, atmosphere, and biosphere. Hy...
