18期

最新文章

• A responsive living material prepared by diffusion reveals extracellular enzyme activity of cyanobacteria AI翻译
  作者：Tang, Lisa; Soulier, Nathan T.; Wheeler, Rebecca; Pokorski, Jonathan K.; Golden, James W.; Golden, Susan S.; Bae, Jinhye
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Chung Ang University
  摘要：Stimuli-responsive engineered living materials (ELMs) can respond to environmental or biochemical cues and have broad utility in biological sensors and machines, but have traditionally been limited to biocompatible scaffolds. This is because they are typically made by mixing cells into a precursor solution before crosslinking. Here, we demonstrate a diffusion mechanism for incorporating cells of the cyanobacterium Synechococcus elongatus sp. PCC 7942 (S. elongatus) into nanoclay-poly-N-isoprop...
• Water- directed pinning is key to tau prion formation AI翻译
  作者：Vigers, Michael P.; Lobo, Samuel; Najafi, Saeed; Dubose, Austin; Tsay, Karen; Ganguly, Pritam; Longhini, Andrew P.; Jin, Yingying; Buratto, Steven K.; Kosik, Kenneth S.; Shell, M. Scott; Shea, Joan-Emma; Han, Songi
  作者单位：University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; Northwestern University
  摘要：Tau forms fibrillar aggregates that are pathological hallmarks of a family of neurodegenerative diseases known as tauopathies. The synthetic replication of disease- specific fibril structures is a critical gap for developing diagnostic and therapeutic tools. This study debuts a strategy of identifying a critical and minimal folding motif in fibrils characteristic of tauopathies and generating seeding- competent fibrils from the isolated tau peptides. The 19- residue jR2R3 peptide (295 to 313) ...
• Dopamine induces fear extinction by activating the reward-responding amygdala neurons AI翻译
  作者：Zhang, Xiangyu; Flick, Katelyn; Rizzo, Marianna; Pignatelli, Michele; Tonegawa, Susumu
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); University of Parma; Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute
  摘要：The extinction of conditioned fear responses is crucial for adaptive behavior, and its impairment is a hallmark of anxiety disorders such as posttraumatic stress disorder. Fear extinction takes place when animals form a new memory that suppresses the original fear memory.In the case of context-dependent fear memory, the new memory is formed within the reward-responding posterior subset of basolateral amygdala (BLA) that is genetically marked by Ppp1r1b+ neurons. These memory engram cells suppr...
• RAD52's active form is not a ring AI翻译
  作者：Borgstahl, Gloria E. O.
  作者单位：University of Nebraska System; University of Nebraska Medical Center
• Behavioral resilience via dynamic circuit firing homeostasis AI翻译
  作者：Hoagland, Adam; Schultz, Ryan; Cai, Zerong; Newman, Zachary L.; Isacoff, Ehud Y.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of Minnesota System; University of Minnesota Twin Cities
  摘要：Homeostatic regulation ensures stable neural circuit output under changing conditions. We find that in Drosophila larvae, either presynaptic weakening due to perturbation of transmitter release or postsynaptic weakening due to perturbation of glutamate receptors at synapses between motor neuron (MN) and muscle has little impact on locomotion, suggesting a nonsynaptic compensatory mechanism. In vivo imaging shows that five different forms of synaptic weakening increase the duration of activity ...
• Twinfilin is a nonprocessive depolymerase which synergizes with formin to dramatically accelerate actin filament uncapping by 300-fold AI翻译
  作者：Reddy, Vishal; Arya, Ankita; Shekhar, Shashank
  作者单位：Emory University; Emory University
  摘要：For over four decades, our understanding of cellular actin dynamics has been guided by the concept of treadmilling. However, this paradigm has been challenged by the evidence that twinfilin can uncap and promote depolymerization of filament barbed ends, though its precise mechanism remains debated. Using single-molecule microscopy and microfluidics-assisted TIRF imaging, we demonstrate that twinfilin transiently associates with barbed ends for similar to 0.2 to 0.5 s, acting as a nonprocessive...
• Dysregulation of MYBL2 impairs extravillous trophoblast lineage development and function, contributing to recurrent spontaneous abortion AI翻译
  作者：Wu, Zhi-Hong; Yi, Cen; Chen, En-Xiang; Xu, Jia-Qi; Li, Cong; Yao, Lu; Li, Fang-Fang; Fu, Li-Juan; Ge, Lu-Xing; Wang, Ying-Xiong; Xie, You-Long; Ding, Yu-Bin; Tang, Jing
  作者单位：Chongqing Medical University; Chongqing Medical University; Chongqing Medical University; Changsha Medical University
  摘要：Recurrent spontaneous abortion (RSA) is a pregnancy- related condition characterized by a complex etiology. While placental trophoblast dysfunction is strongly associated with the development and progression of RSA, the underlying molecular mechanisms remain poorly understood. In this study, we observed a significant decrease in the expression and the placentas of abortion- prone (AP) mice. Utilizing human trophoblast stem cells (hTSCs), we identified MYBL2 as a critical regulator of hTSCs ste...
• Differentiated planetesimals record differing sources of sulfur in inner and outer solar system materials AI翻译
  作者：Heiny, Elizabeth A.; Stolper, Edward M.; Eiler, John M.
  作者单位：California Institute of Technology
  摘要：The isotope anomalies of noncarbonaceous (NC) and carbonaceous (CC) extraterrestrial materials provide a framework for tracing the distribution and accretion of matter in the early solar system. Here, we extend this framework to sulfur (S)-one of six life-essential volatile elements [T-C similar to 664 K]-via the mass-independent S-isotope compositions of differentiated meteorites. We observe that on average, NC and CC iron meteorites are characterized by distinct Delta S-33 (Delta S-33(NC) = ...
• A universal strategy for multicolor organic circularly polarized afterglow materials with high dissymmetry factors AI翻译
  作者：Yin, Chenjia; Sun, Siyu; Yan, Zi-Ang; Hu, Honglong; Jiang, Ping; Xu, Zhuoran; Tian, He; Ma, Xiang
  作者单位：East China University of Science and Technology; East China University of Science and Technology; East China University of Science and Technology
  摘要：Materials with pure organic circularly polarized afterglow (CPA) have attracted significant attention due to their spatiotemporal-resolved optical properties, yet achieving simultaneous high dissymmetry factor (glum) and multicolor ultralong emission remains a challenge. Here, we establish a universal energy transfer-photon coupling strategy to realize CPA spanning from blue to red with record-high glum (up to 1.90) and ultralong lifetimes (>6 s). Systematic characterization of nonchiral donor...
• Micromechanical modeling of triphasic granular media AI翻译
  作者：Das, Amiya Prakash; Zhao, Jidong; Sweijen, Thomas
  作者单位：Hong Kong University of Science & Technology; Utrecht University
  摘要：This paper presents pore unit assembly-discrete element model (PUA-DEM), a pore-scale hydromechanical framework that resolves interactions between mobile granular particles and multiphase fluids in unsaturated granular media. The framework uniquely integrates DEM with pore-scale hydrodynamic models to capture unsaturated flow dynamics, while leveraging a two-way coupling mechanism to ensure bidirectional fluid-grain feedback through stabilized domain partitioning. Further innovations include a...