33期

最新文章

• Repeated polyploidization shapes divergence in floral morphology in Lithophragma bolanderi (Saxifragaceae) AI翻译
  作者：Gross, Karin; Yazdi, Homa Papoli; Schlager, Elisabeth; Lilley, Jodie; Romero-Bravo, Andres; Runemark, Anna; Thompson, John N.; Friberg, Magne
  作者单位：Uppsala University; Lund University; Salzburg University; University of Manchester; University of Sussex; University of California System; University of California Santa Cruz
  摘要：Polyploidization is an important driver of evolution and diversification in flowering plants. Here, we assess how repeated polyploidization may have shaped diversification of floral morphology in Lithophragma bolanderi (Saxifragaceae). This species comprises multiple cytotypes and varies geographically in its interactions with specialized pollinating moths in the genus Greya (Prodoxidae). Past studies have shown that coevolution with these moths has favored particular suites of floral characte...
• The distortion-push mechanism for the γ subunit rotation in F1-ATPase AI翻译
  作者：Motohashi, Masahiro; Oide, Mao; Kobayashi, Chigusa; Jung, Jaewoon; Muneyuki, Eiro; Sugita, Yuji
  作者单位：Chuo University; University of Osaka; RIKEN; RIKEN
  摘要：F1-ATPase comprises the stator ring consisting of alpha 3 beta 3 subunits and the rotor gamma subunit. The gamma subunit rotation mechanism has been extensively investigated by biochemical analyses, structural studies, single-molecule measurements, and computational studies. Recent cryoelectron microscopy (cryo-EM) structures of F1-ATPase from the thermophilic bacterium Bacillus PS3 (TF1) provide us with further possibilities for a better understanding of the gamma-rotation mechanisms. Using c...
• Layer 1 NDNF interneurons form distinct subpopulations with opposite activation patterns during sleep in freely behaving mice AI翻译
  作者：Brecier, Aurelie; Mailhos, Gaelle; Jarzebowski, Przemyslaw; Li, Yuqi; Paulsen, Ole; Hay, Y. Audrey
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Claude Bernard Lyon 1; Universite Jean Monnet; University of Cambridge; University of London; University College London
  摘要：Non-rapid eye movement (NREM) sleep facilitates memory consolidation by transferring information from the hippocampus to the neocortex. This transfer is thought to occur primarily when hippocampal sharp-wave ripples (SWRs) and thalamocortical spindles are synchronized. However, the mechanisms underlying this synchronization remain unknown. In this study, we investigated the role of cortical layer 1 neuron-derived neurotrophic factor (NDNF)-expressing (L1 NDNF) interneurons in gating informatio...
• Dynamic GLUT trafficking at high glucose levels enhances insulin secretion: Dysregulation leads to decreased insulin secretion during type 2 diabetes AI翻译
  作者：Pallavi, Anuma; Sinha, Neha; ArunKumar, Nagapriya K.; Kothegala, Lakshmi; Gandasi, Nikhil R.
  作者单位：Indian Institute of Science (IISC) - Bangalore; University of Gothenburg; Uppsala University
  摘要：Glucose transporters (GLUT1/2) facilitate glucose uptake in pancreatic beta cells, triggering insulin secretion. The availability of GLUTs at the plasma membrane (PM) is governed by its expression, delivery to the membrane, and endocytosis. Little is known about the dynamics of GLUT trafficking in response to glucose that triggers glucose-stimulated insulin secretion. In our study, we found that the recruitment of GLUTs to the PM of beta cells correlates with increasing glucose concentrations....
• Genomes of nitrogen-fixing eukaryotes reveal an alternate path for organellogenesis AI翻译
  作者：Frail, Sarah; Steele-Ogus, Melissa; Doenier, Jon; Moulin, Solene L. Y.; Braukmann, Tom; Xu, Shouling; Yeh, Ellen
  作者单位：Stanford University; Stanford University; Carnegie Institution for Science; Stanford University; Chan Zuckerberg Initiative (CZI)
  摘要：Endosymbiotic gene transfer (EGT) and import of host-encoded proteins have been considered hallmarks of organelles necessary for stable integration of two cells. However, newer endosymbiotic models have challenged the origin and timing of such genetic integration during organellogenesis. Epithemia diatoms contain diazoplasts, obligate endosymbionts derived from cyanobacteria that are closely phylogenetically related to UCYN-A, a recently described nitrogen-fixing organelle. Diazoplasts functio...
• Remote analysis and management of sweat biomarkers using a wearable microfluidic sticker in adult cystic fibrosis patients AI翻译
  作者：Nelson, Rachel S.; Grossman, Margaret G.; Klug, Zasu M.; Calamari, Mia; Donayre, Alvaro; Cybulski, Thaddeus; Schooley, Jared; Griffith, Garett J.; Corcos, Daniel M.; Wright, Donald E.; Wallace, Jessica C.; Yang, Da Som; Wright Jr, John A.; Rogers, John A.; Lee, Stephen P.; Ghaffari, Roozbeh; Aranyosi, A. J.; Jain, Manu
  作者单位：Northwestern University; Feinberg School of Medicine; Northwestern University; Northwestern University; Chung Ang University; Northwestern University; Northwestern University; Northwestern University; US Department of Veterans Affairs; Veterans Health Administration (VHA); Jesse Brown VA Medical Center; Northwestern University
  摘要：Sweat parameters such as volume and chloride concentration may offer invaluable clinical insights for people with CF (PwCF). Pilocarpine-induced sweat collection for chloridometry measurement is the gold standard for a CF diagnosis, but this technique is cumbersome and not suitable for remote settings or repeat measurements. We have previously reported the utility of a skin-interfaced microfluidic device (CF Patch) in conjunction with a smartphone image processing platform that enables real-ti...
• Sustained benefits of long-term biochar application for food security and climate change mitigation AI翻译
  作者：Yang, Jingrui; Xia, Longlong; Groenigen, Kees Jan van; Zhao, Xu; Ti, Chaopu; Wang, Weilu; Du, Zhangliu; Fan, Mingsheng; Zhuang, Minghao; Smith, Pete; Lal, Rattan; Butterbach-Bahlh, Klaus; Han, Xiaori; Meng, Jun; Liu, Jia; Cai, Hongguang; Cheng, Yanhong; Liu, Xingren; Shu, Xiangyang; Jiao, Xiaoyan; Pan, Zhandong; Tang, Guangmu; Yan, Xiaoyuan
  作者单位：Chinese Academy of Sciences; Nanjing Institute of Soil Science, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Exeter; Yangzhou University; Yangzhou University; China Agricultural University; University of Aberdeen; University System of Ohio; Ohio State University; Aarhus University; Helmholtz Association; Karlsruhe Institute of Technology; Shenyang Agricultural University; Jiangxi Academy of Agricultural Sciences; Jilin Academy of Agricultural Sciences; Chinese Academy of Agricultural Sciences; Institute of Environment & Sustainable Development in Agriculture, CAAS; Sichuan Normal University; Shanxi Agricultural University; Gansu Agricultural University; Xinjiang Academy of Agricultural Sciences
  摘要：Biochar application offers significant potential to enhance food security and mitigate climate change. However, most evidence stems from short-term field experiments (<= 3 y), leaving uncertainty about the long-term sustainability of these benefits, especially with annual biochar additions to soils. To address this knowledge gap, we analyzed a global dataset from 438 studies (3,229 observations) and found that long-term annual biochar application (>= 4 y) not only sustains but often enhances i...
• Trends in coastal storm impacts are not only about changes in hurricanes AI翻译
  作者：Broccoli, Anthony J.
  作者单位：Rutgers University System; Rutgers University New Brunswick
• Evolutionarily divergent nidovirus with an exceptionally large genome identified in Pacific oysters undergoing mass mortality AI翻译
  作者：Zhong, Kevin Xu; Chan, Amy M.; Miller, Kristina M.; Saunders, Rob; Suttle, Curtis A.
  作者单位：University of British Columbia; Fisheries & Oceans Canada; University of British Columbia; University of British Columbia; University of British Columbia
  摘要：Metatranscriptomic data from a mass-mortality event of adult Pacific Oysters, Crassostrea (Magallana) gigas, the most widely cultivated shellfish globally, revealed a nidovirus shown to replicate in a bivalve, Pacific Oyster Nidovirus 1 (PONV1). At 64,331 bp of linear bisegmented, positive-sense single-stranded RNA, PONV1 has one of the largest genomes reported for an RNA virus. Moreover, transcriptomic data reveal that many conspecific viruses of PONV1 occur in Pacific oysters from Europe and...
• A 65-kb deletion survey identifies a distal cis-regulatory region for red-light induction of Ghd7, a key rice floral repressor AI翻译
  作者：Ogo, Yuko; Kawauchi, Takumi; Mimura, Manaki; Naito, Ken; Itoh, Hironori; Izawa, Takeshi
  作者单位：National Agriculture & Food Research Organization - Japan; University of Tokyo; National Agriculture & Food Research Organization - Japan; National Agriculture & Food Research Organization - Japan
  摘要：The Ghd7 (Grain number, plant height, and heading date 7)gene integrates red light signals and circadian rhythms to control floral repression under long-day conditions in rice. CRISPR/Cas9 systems were employed to create a series of deletion mutant lines in the upstream regions of Ghd7, covering a 65-kb genomic region from its transcription start site (TSS). These deletions ranged from 2 to 25 kb in size. Three deletion lines, those from 0 to-3 kb (0/-3 K), -20 to-40 kb (-20/-40 K), and-26 to-...