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作者：Jiang, Jinghui; Guo, Wei; Chen, Xudong; He, Qijing; Wang, Yubo; Zhu, Xiaohui; Yan, Liying; Qiao, Jie; Xiao, Bailong
作者单位：Tsinghua University
摘要：The mechanically activated PIEZO1ion channel is genetically linked to numerous physiological and pathophysiological processes. For example, deleting PIEZO1 in mice leads to defective lymphatic vessel development, while nonsense mutations in humans are associated with autosomal recessive generalized lymphatic dysplasia (GLD) and nonimmune hydrops fetalis. However, it remains unclear whether PIEZO1-dependent biological processes are directly mediated by its intrinsic mechanosensitivity. Here, we...
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作者：Leuenberger, Wendy; Doser, Jeffrey W.; Belitz, Michael W.; Ries, Leslie; Haddad, Nick M.; Thogmartin, Wayne E.; Zipkin, Elise F.
作者单位：Michigan State University; Michigan State University; North Carolina State University; Georgetown University; Michigan State University; United States Department of the Interior; United States Geological Survey
摘要：Insects are declining worldwide. These declines have been documented across taxonomic groups and are worrisome given ecosystem services provided by insects. Long-term data have illuminated butterfly declines across geographic regions. However, critical questions remain on how butterfly declines are distributed across species and functional groups, limiting effective conservation. Here, we show unprecedented changes in butterfly biodiversity resulting from 32 y of species levels declines throug...
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作者：Rastandeh, Amineh; Makasarashvili, Nino; Dhaliwal, Herman K.; Baker, Sherry; Subramanian, Sundharraman; Villarreal, Daniel A.; Gamez, Elmer I.; Parent, Kristin N.; Garmann, Rees F.
作者单位：California State University System; San Diego State University; California State University System; San Diego State University; Michigan State University; California State University System; San Diego State University
摘要：Some RNA viruses package their genomes with extraordinary selectivity, assembling protein capsids around their own viral RNA while excluding nearly all host RNA. How the assembling proteins distinguish viral RNA from host RNA is not fully understood, but RNA structure is thought to play a key role. To test this idea, we perform in-cellulo packaging experiments using bacteriophage MS2 coat proteins and a variety of RNA molecules in Escherichia coli. In each experiment, plasmid-derived RNA molec...
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作者：Jaishankar, Jananee; Yang, Hyojik; O'Keefe, Ian P.; Tenaglia, Brandon M.; Kinch, Lisa N.; Ernst, Robert K.; Orth, Kim
作者单位：University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; University of Texas System; University of Texas Southwestern Medical Center
摘要：Vibrio parahaemolyticus (V. para), a Gram-negative halophilic bacterium, is the leading cause of seafood-borne gastroenteritis. While the cytotoxic and enterotoxic capabilities of this bacterium have been previously investigated, the strategies it employs to circumvent innate immune detection by the host remain poorly understood. Bacterial lipopolysaccharide (LPS) serves as the major pathogen-associated molecular pattern that triggers host inflammatory responses, and its lipid A structure cont...
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作者：Xie, Yuyang; Shen, Zehao; Camarero, J. Julio; Penuelas, Josep; Wang, Xuejing; Li, Jitang; Rao, Wenge; Chen, Xiangwu; Zhao, Fu; Feng, Xiao
作者单位：Peking University; Peking University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Yunnan University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto Pirenaico de Ecologia (IPE); Centro de Investigacion Ecologica y Aplicaciones Forestales (CREAF-CERCA); Centro de Investigacion Ecologica y Aplicaciones Forestales (CREAF-CERCA); Autonomous University of Barcelona
摘要：Alpine treeline is a prominent biogeographic feature worldwide, determined by the physiological limit of tree life form. There are considerable variations in the various dimensions of physiological limit among tree taxa; thus, varied environmental drivers and spatial patterns are expected for different tree taxa at treelines. However, such taxonomic variability of treeline is often overlooked in large-scale studies. Here, we assembled, to our knowledge, the most comprehensive dataset of tree s...
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作者：Zhang, Zhuquan; Ning, Honglie; Liu, Zi-Jie; Hou, Jin; Mohite, Aditya D.; Baldini, Edoardo; Gedik, Nuh; Nelson, Keith A.
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Rice University; Rice University; University of Texas System; University of Texas Austin
摘要：In 1964, Keldysh laid the groundwork for strong-field physics in atomic, molecular, and solid-state systems by delineating a ubiquitous transition from multiphoton absorption to classical field-driven electron tunneling under intense electromagnetic waves. While both processes in semiconductors can generate carriers and result photon emission through electron-hole recombination, the low quantum yields most materials have hindered direct observation of the Keldysh crossover. Leveraging the larg...
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作者：Jaijyan, Dabbu Kumar; Selariu, Anca; Cosme, Ruth Cruz -; Tong, Mingming; Yang, Shaomin; Stefa, Alketa; Kekich, David; Sadoshima, Junichi; Herbig, Utz; Tang, Qiyi; Church, George; Parrish, Elizabeth L.; Zhu, Hua
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作者：Lehmann, Johannes; Barrios, Edmundo; Devault, Mariana; Li, Lucinda; Nelson, Rebecca; Six, Johan; Trimmer, John
作者单位：Cornell University; Cornell University; Cornell University; Food & Agriculture Organization of the United Nations (FAO); Cornell University; Swiss Federal Institutes of Technology Domain; ETH Zurich; Syracuse University
摘要：The circular bionutrient economy is defined here as the circular economy of nutrients in managed organic residues. Here, we posit that biochar technology can stimulate the circular bionutrient economy by meeting the following three requirements: 1) nutrients are captured in a dry form, increasing market value and lowering transportation cost; 2) individual nutrients can be captured separately and combined as needed for particular plants and soils; 3) all pathogens and most pollutants can be re...
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作者：Elboim, Dor; Peres, Yuval; Peretz, Ron
作者单位：Stanford University; Bar Ilan University
摘要：In several settings (e.g., sensor networks and social networks), nodes of a graph are equipped with initial opinions, and the goal is to estimate the average of these opinions using local operations. A natural algorithm to achieve this is the edge-averaging process, where edges are repeatedly selected at random (according to independent Poisson clocks) and the opinions on the nodes of each selected edge are replaced by their average. The effectiveness of this algorithm is determined by its con...
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作者：Jeon, Jaepyo; Moore, Travis I.; So, Insuk; Freichel, Marc; Flockerzi, Veit; Birnbaumer, Lutz; Zhu, Michael X.
作者单位：University of Texas System; University of Texas Health Science Center Houston; Seoul National University (SNU); Ruprecht Karls University Heidelberg; German Centre for Cardiovascular Research; Universitatsklinikum des Saarlandes; Pontificia Universidad Catolica Argentina; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
摘要：Transient Receptor Potential Canonical 4 (TRPC4) channels have been implicated in multiple neurological functions, including anxiety and sociability. TRPC4 variants were also found in patients with autism. However, the contributions of TRPC4 to neurodevelopment remain undefined. Here, we show that neurobehavioral deficits appear early in young TRPC4 knockout (Trpc4-/-) mice immediately after weaning, manifesting as alterations in multiple, limbic-related behaviors, such as nesting, marble bury...
