33期

最新文章

• TRIM24 as a therapeutic target in endocrine treatment-resistant breast cancer AI翻译
  作者：Padrao, Nuno; Gregoricchio, Sebastian; Eickhoff, Nils; Dong, Jing; Luzietti, Lara; Bossi, Daniela; Severson, Tesa M.; Siefert, Joseph; Calcinotto, Arianna; Buluwela, Laki; Collier, Maria Donaldson; Ali, Sima; Young, Leoni; Theurillat, Jean-Philippe; Varestija, Damir; Zwart, Wilbert
  作者单位：Netherlands Cancer Institute; Royal College of Surgeons - Ireland; Institute of Oncology Research (IOR); Universita della Svizzera Italiana; Imperial College London; Royal College of Surgeons - Ireland; Beaumont Hospital Dublin
  摘要：While Estrogen receptor alpha (ER alpha)+ breast cancer treatment is considered effective, resistance to endocrine therapy is common. Since ER alpha is still the main driver in most therapy-resistant tumors, alternative therapeutic strategies are needed to disrupt ER alpha transcriptional activity.In this work, we position TRIM24 as a therapeutic target in endocrine resistance, given its role as a key component of the ER alpha transcriptional complex. TRIM24 interacts with ER alpha and other w...
• Plant-specific mitochondrial fission machinery connects mitochondrial dynamics and mitophagosome formation for piecemeal mitophagy AI翻译
  作者：Ma, Juncai; Li, Chaorui; Ren, Kaike; Zhang, Kaiyan; Feng, Lanlan; Law, Kai Ching; Chung, Ka Kit; Bing, Yizhou; Gao, Caiji; Kang, Byung -Ho; Zhuang, Xiaohong
  作者单位：Chinese University of Hong Kong; Chinese University of Hong Kong; South China Normal University; South China Normal University
  摘要：As the energy center of the cell, mitochondria display enormous metabolic plasticity to meet the cellular demand for plant growth and development, which is tightly linked to their structural and dynamic plasticity. Mitochondrial number and morphology are coordinated through the actions of the mitochondrial division and fusion. Meanwhile, damaged mitochondrial contents are removed to avoid excess toxicity to the plant cells. Mitophagy, a selective degradation pathway of mitochondria through a d...
• Our current climate already merits serious research and policy attention AI翻译
  作者：Obradovich, Nick; Lawrance, Emma L.; Minor, Kelton
  作者单位：Laureate Institute for Brain Research, Inc.; Massachusetts Institute of Technology (MIT); University of Tulsa; Imperial College London; Imperial College London; Columbia University; University of Copenhagen
• Predictability and the pleasure of music AI翻译
  作者：Belfi, Amy M.
  作者单位：University of Missouri System; Missouri University of Science & Technology
• Global profiling of N-terminal cysteine-dependent degradation mechanisms AI翻译
  作者：Bekturova, Aizat; Makaros, Yaara; Ben -David, Shahar; Koren, Itay
  作者单位：Bar Ilan University
  摘要：Hypoxia, a condition characterized by insufficient oxygen supply, challenges cellular homeostasis and energy production, triggering adaptive responses to promote survival under these stressful conditions. One key strategy involves enzymatic oxidation of N-terminal cysteine residues coupled with proteolysis through the Cys-Arg/N-degron pathway. Despite hundreds of human proteins possessing N-terminal cysteine, very few have been identified as substrates of this pathway, and its substrate select...
• Circulating cell- free RNA signatures for the characterization and diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome AI翻译
  作者：Gardella, Anne E.; Eweis-LaBolle, Daniel; Loy, Conor J.; Belcher, Emma D.; Lenz, Joan S.; Franconi, Carl J.; Scofield, Sally Y.; Grimson, Andrew; Hanson, Maureen R.; De Vlaminck, Iwijn
  作者单位：Cornell University; Cornell University
  摘要：People living with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) experience heterogeneous and debilitating symptoms that lack sufficient biological explanation, compounded by the absence of accurate, noninvasive diagnostic tools. To address these challenges, we explored circulating cell-free RNA (cfRNA) as a blood-borne bioanalyte to monitor ME/CFS. cfRNA is released into the bloodstream during cellular turnover and reflects dynamic changes in gene expression, cellular signaling,...
• A proteomic signature of healthspan ( vol 122 , e2414086122, 2025) AI翻译
  作者：Kuo, Chia-Ling; Liu, Peiran; Drouard, Gabin; Vuoksimaa, Eero; Kaprio, Jaakko; Ollikainen, Miina; Chen, Zhiduo; Pilling, Luke C.; Atkins, Janice L.; Fortinsky, Richard H.; Kuchel, George A.; Diniz, Breno S.
  作者单位：University of Connecticut; University of Connecticut; University of Helsinki; University of Exeter; University of Connecticut
• The 2025 Mw7.7 Mandalay, Myanmar, earthquake reveals a complex earthquake cycle with clustering and variable segmentation on the Sagaing Fault AI翻译
  作者：Antoine, Solene L.; Shrestha, Rajani; Milliner, Chris; Im, Kyungjae; Rollins, Chris; Wang, Kang; Chen, Kejie; Avouac, Jean- Philippe
  作者单位：California Institute of Technology; Southern University of Science & Technology
  摘要：We use remote sensing observations to document surface deformation caused by the 2025 M(w)7.7 Mandalay earthquake. This event is a unique case of an extremely long (similar to 510 km) and sustained supershear rupture probably favored by the rather smooth and continuous geometry of this section of the structurally mature Sagaing Fault. The seismic rupture involved the locked portion of the fault over its entire depth extent (0 to 13 km) with a remarkably uniform slip distribution that averages ...
• Dural ectopic lymphatic structures accumulate during aging and exhibit dysregulation in neurodegenerative diseases AI翻译
  作者：Davidi, Amit Fruitman; Shirenova, Sophie; Michaelovich, Dolev; Benedetti, Giulio; Shtrasberg, Hadar; Shoval, Irit; Hauschner, Hagit; Oz, Gal; Vardy, Karin; Hirsh, Tamir; Madar, Ravit; Stern, Edward A.; Rosenmann, Hanna; Biragyn, Arya; Okun, Eitan
  作者单位：Bar Ilan University; Bar Ilan University; Bar Ilan University; Hebrew University of Jerusalem; Hadassah University Hospital; Hebrew University of Jerusalem; Hebrew University of Jerusalem; Hadassah University Hospital; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
  摘要：The meninges serve as a critical interface between the peripheral immune system and the central nervous system, playing a crucial role in maintaining parenchymal homeostasis. Neurodegenerative disorders, such as amyloidosis and tauopathies, are marked by the accumulation of extracellular neurotoxic amyloid-f3 (Af3) plaques and intracellular tau tangles, respectively, leading to neuronal cell death and cognitive decline. The role of the adaptive immune response in these pathologies remains unde...
• Atomistic mechanisms of calcium permeation modulated by Q/R editing and selectivity filter mutations in GluA2 AMPA receptors AI翻译
  作者：Heiser, Florian; Biedermann, Johann; Kuru, Ece; Plested, Andrew J. R.; Sun, Han
  作者单位：Humboldt University of Berlin; Leibniz Association; Leibniz Forschungsinstitut furr Molekulare Pharmakologie (FMP); Technical University of Berlin; Technische Universitat Dresden; Humboldt University of Berlin
  摘要：GluA2 is a key subunit of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) ion channels that is abundantly expressed in the vertebrate brain. Posttranscriptional Q/R editing of GluA2 renders AMPARs nearly impermeable to calcium ions, which is crucial for their normal function. Although previous studies have characterized conductivity and selectivity differences between edited and unedited GluA2 variants and heteromeric receptors incorporating GluA2, the consequences of por...