33期

最新文章

• Structural insights into VRC01-class bnAb precursors with diverse light chains elicited in the IAVI G001 human vaccine trial AI翻译
  作者：Lin, Xiaohe; Cottrell, Christopher A.; Kalyuzhniy, Oleksandr; Tingle, Ryan; Kubitz, Michael; Lu, Danny; Yuan, Meng; Schief, William R.; Wilson, Ian A.
  作者单位：Scripps Research Institute; Scripps Research Institute; Scripps Research Institute; International AIDS Vaccine Initiative; Scripps Research Institute
  摘要：The development of germline-targeting vaccines represents a potentially transformative strategy to elicit broadly neutralizing antibodies (bnAbs) against HIV and other antigenically diverse pathogens. Here, we report on structural characterization of vaccine-elicited VRC01-class bnAb precursors in the IAVI G001 Phase 1 clinical trial with the eOD-GT8 60mer nanoparticle as immunogen. High-resolution X-ray structures of eOD-GT8 monomer complexed with Fabs of five VRC01-class bnAb precursors with...
• Engineering a protease-stable, oral single-domain antibody to inhibit IL-23 signaling (vol 122, e2501635122, 2025) AI翻译
  作者：Ota, Naruhisa; Davies, Christopher W.; Kang, Jing; Yan, Donghong; Scherl, Alexis; Wong, Anne; Cook, Ryan; Tao, Xun; Dunlap, Debra; Klabunde, Sha; Mantik, Priscilla; Mohanan, Vishnu; Lin, WeiYu; McBride, Jacqueline; Sadekar, Shraddha; Storek, Kelly M.; Lupardus, Patrick; Ye, Zhengmao; Wallweber, Heidi Ackerly; Kiefer, James R.; Xu, Min; Chan, Pamela; Nagapudi, Karthik; Yi, Tangsheng; Koerber, James T.
• Supporting Information for Rei et al., Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway ( vol 112 , pg 7291-7296 , 2015 ) AI翻译
  作者：Rei, Damien; Mason, Xenos; Seo, Jinsoo; Rudenko, Andrii; Wang, Jun; Rueda, Richard; Siegert, Sandra; Cho, Sukhee; Canter, Rebecca G.; Mungenast, Alison E.; Deisseroth, Karl; Tsai, Li - Huei
• Geographical diversity of peer reviewers shapes author success AI翻译
  作者：Dumlao, James M. Zumel; Teplitskiy, Misha
  作者单位：University of Michigan System; University of Michigan
  摘要：Scientific institutions like funding agencies and journals rely on peer reviewers to select among competing submissions. How does the geographical diversity of reviewers affect which authors are selected? If reviewers typically favor submissions from their own countries, but reviewers from only some countries are well represented in the reviewer pool, this can create a geographical representation bias favoring authors from those well-represented countries. Using administrative data on 204,718 ...
• Tumor-promoting UBR4 coordinates impaired mitophagy-associated senescence and lung adenocarcinoma pathogenesis (vol 122 , e2425015122, 2025) AI翻译
  作者：Jeong, Dawon; Park, Seo Hyeong; Kim, Jiwon; Kim, Hyeyoon; Jang, Yejin; Koh, Jaemoon; Jeon, Yoon Kyung; Tasaki, Takafumi; Kwon, Yong Tae; Han, Dohyun; Cho, Sung-Yup; Lee, Min Jae
• Gene regulatory logic of the interferon-β enhancer is characterized by two selectively deployed modes of transcription factor synergy AI翻译
  作者：Schiffman, Allison; Cheng, Zhang; Ourthiague, Diana; Hoffmann, Alexander
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
  摘要：Type I interferon IFN beta is a key immune response cytokine, and when its expression is dysregulated, it causes disease. The regulation of IFN beta enhancer has been a touchpoint of mammalian gene control research since the discovery of functional synergy between two stimulus-responsive transcription factors (TFs), nuclear factor kappa B (NF kappa B) and interferon regulatory factors (IRF). However, subsequent gene knockout studies revealed that in some conditions either NF kappa B or IRF act...
• Therapeutic CD8+T cell tissue retention and immunomodulation during ART interruption fail to prevent SIV rebound AI翻译
  作者：Pampena, M. Betina; Samer, Sadia; Viox, Elise G.; Nguyen, Kevin; Deleage, Claire; Kuri-Cervantes, Leticia; Regan, James; Wu, Vincent H.; Docken, Steffen; Safrit, Jeffrey T.; Bar, Katharine J.; Keele, Brandon F.; Davenport, Miles P.; Paiardini, Mirko; Betts, Michael R.
  作者单位：University of Pennsylvania; University of Pennsylvania; Emory University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; University of New South Wales Sydney; Kirby Institute; Emory University; Sanofi-Aventis; Sanofi USA
  摘要：A primary obstacle for HIV elimination is the long-term viral reservoir in lymphoid tissues (LT) that can cause rebound viremia if therapy is stopped. Cytotoxic CD8+T cells are critical for control of HIV and Simian immunodeficiency virus (SIV) viremia; however, CD8+ T cells that migrate to LT are primarily noncytotoxic, calling into question whether these cells could reduce the viral reservoir on antiretroviral therapy (ART) or control viral replication when therapy is halted. To determine wh...
• Mechanistic insights into the small-molecule inhibition of influenza A virus entry AI翻译
  作者：Xu, Yan; Anirudhan, Varada; Gaisina, Irina N.; Du, Haijuan; Alqarni, Saad; Moore, Terry W.; Caffrey, Michael; Manicassamy, Balaji; Zhou, Tongqing; Rong, Lijun; Xu, Kai
  作者单位：University System of Ohio; Ohio State University; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); University Ha'il; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Iowa; University System of Ohio; Ohio State University
  摘要：Influenza A virus (IAV) is a zoonotic pathogen responsible for seasonal and pandemic flu. The extensive genetic and antigenic diversity within and between IAV phylogenetic groups presents major challenges for developing universal vaccines and broad-spectrum antiviral therapies. Current interventions provide limited protection due to the virus's high mutation rate and capacity for immune evasion. Recent advancements in viral hemagglutinin (HA)-targeting small-molecule entry inhibitors offer a p...
• Solution spillover: Pairing issues with ideological solutions fuels polarization AI翻译
  作者：Kafka, Adrienne M.; Campbell, Troy H.; Kay, Aaron C.
  作者单位：Duke University
  摘要：Recent research has focused on understanding ideological and affective political polarization in the United States; however, the polarization of issue salience-defined as personal beliefs about how important or concerning an issue is, and how much attention or priority it deserves-has garnered less attention, especially regarding its underlying causes. We propose that issue salience polarization, particularly that of ideologically neutral issues, is driven in part by two psychological processe...
• Ludwig-Soret microscopy with the vibrational photothermal effect AI翻译
  作者：Toda, Keiichiro; Ideguchi, Takuro
  作者单位：University of Tokyo
  摘要：Vibrational microscopy provides label-free, bond-selective chemical contrast by detecting molecular vibrations, making it invaluable for biomedical research. While conventional methods rely on the direct detection of Raman scattering or infrared absorption, recently developed vibrational photothermal (ViP) microscopy achieves chemical contrast indirectly through refractive index (RI) changes. This indirect approach enables unique imaging capabilities beyond traditional chemical imaging. Here, ...