33期

最新文章

• Structural basis and affinity improvement for an ATP-binding AI翻译
  作者：Jiang, Yan; Zhang, Yuchao; Wan, Liqi; Cui, Cheng; Guo, Pei; Han, Da; Tan, Weihong; Patel, Dinshaw
  作者单位：Hunan University; Chinese Academy of Sciences; Hangzhou Institute of Medicine, CAS; Shanghai Jiao Tong University
  摘要：DNA aptamers that bind small molecules with high affinity have revolutionized the fields of biosensing and bioimaging. Recently, a DNA aptamer named 1301b has been identified as the most potent DNA aptamer for the binding of adenosine triphosphate (ATP) with a dissociation constant (K-D) of similar to 2.7 mu M. However, the structural basis and recognition mechanism remain unclear, hindering further development of this DNA aptamer. In this study, we first design a shortened DNA aptamer namely ...
• Spatiotemporal distribution of the glycoprotein pherophorin II reveals stochastic geometry of the growing ECM of Volvox carteri AI翻译
  作者：von der Heyde, Benjamin; Srinivasan, Anand; Birwa, Sumit Kumar; von der Heyde, Eva Laura; Hoehn, Steph S. M. H.; Coldstein, Raymond E.; Hallmann, Armin
  作者单位：University of Bielefeld; University of Cambridge
  摘要：The evolution of multicellularity involved the transformation of a simple cell wall of unicellular ancestors into a complex, multifunctional extracellular matrix (ECM). A suitable model organism to study the formation and expansion of an ECM during ontogenesis is the multicellular green alga Volvox carteri, which, along with the related volvocine algae, produces a complex, self-organized ECM composed of multiple substructures. These self-assembled structures primarily consist of hydroxyproline...
• Targeted deletions of large syntenic regions in Arabidopsis thaliana AI翻译
  作者：Papikian, Ashot; Rattner, Rachel J.; Kao, Jenni; Hauser, Neil; Allsing, Nicholas; Mamerto, Allen; Hartwick, Nolan T.; Colt, Kelly; Michael, Todd P.
  作者单位：Salk Institute; University of California System; University of California San Diego; University of California System; University of California San Diego
  摘要：Plant genomes have undergone multiple rounds of whole-genome duplication (WGD) throughout their evolutionary history. As a result, many species, including Arabidopsis thaliana, retain duplicated genomic segments, or syntenic regions, which harbor large numbers of paralogous genes preserved from these ancient WGD events. We deleted four large, duplicated blocks, ranging from similar to 115 kb to similar to 684 kb using Staphylococcus aureus Cas9 to explore the effects of knocking out these bloc...
• Scalable high-voltage Zn||MnO2 batteries achieved by mild amphiphilic hydrogel electrolytes AI翻译
  作者：Li, Chuan; Liang, Bochun; Chen, Ze; Zhang, Rong; Cui, Huilin; Wang, Yanbo; Li, Qing; Peng, Chao; Fan, Jun; Pei, Zengxia; Zhi, Chunyi
  作者单位：City University of Hong Kong; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; University of Sydney; City University of Hong Kong; City University of Hong Kong; University of Hong Kong
  摘要：The practical applications of aqueous Zn vertical bar vertical bar MnO2 batteries are limited by their small areal capacity, low discharging plateau, and clumsy packing device. Currently, the high potential MnO2/Mn2+ redox conversion can only be well activated in electrolytes with a very low pH value, which is not friendly to the Zn metal anode. To overcome these limitations, we have designed mild amphiphilic hydrogel electrolytes (AHEs) with a wide electrochemical stability window (ESW) and h...
• Stress granule-mediated ZBP1 activation drives necroptotic cell death in non-obstructive azoospermia and testicular aging AI翻译
  作者：Lei, Hongen; Li, Dianrong; Chen, Jie; Du, Baowen; Jiang, Kaiju; Xu, Tao; Han, Hu; Fan, Weiliang; Tian, Long; Wang, Xiaodong
  作者单位：Capital Medical University; Capital Medical University; National Institute of Biological Sciences, Beijing; Tsinghua University
  摘要：Male infertility remains a major unmet medical challenge, with poorly defined molecular mechanisms and no effective therapies. Here, we identify a stress granule-mediated necroptotic pathway as a key driver of non-obstructive azoospermia, a severe form of male infertility marked by the loss of spermatogenesis. Environmental or physiological stress activates eIF2 alpha kinases, inducing stress granule formation and the recruitment of ZBP1 and RIPK3 into a cytoplasmic complex. This assembly trig...
• Anyon superconductivity from topological criticality in a Hofstadter-Hubbard model AI翻译
  作者：Divic, Stefan; Crepel, Valentin; Soejima, Tomohiro; Song, Xue-Yang; Millis, Andrew J.; Zaletel, Michael P.; Vishwanath, Ashvin
  作者单位：University of California System; University of California Berkeley; Simons Foundation; Flatiron Institute; Harvard University; Hong Kong University of Science & Technology; Columbia University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
  摘要：We argue that the combination of strong repulsive interactions and high magnetic fields can generate electron pairing and superconductivity. Inspired by the large lattice constants of moir & eacute; materials, which make large flux per unit cell accessible at laboratory fields, we study the triangular lattice Hofstadter-Hubbard model at one-quarter flux quantum per plaquette, where previous literature has argued that a chiral spin liquid separates a weak-coupling integer quantum Hall phase and...
• A stochastic theory of urban metabolism AI翻译
  作者：Hendrick, Martin; Rinaldo, Andrea; Manoli, Gabriele
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Centro Euro-Mediterraneo sui Cambiamenti Climatici (CMCC)
  摘要：A current tenet in the science of cities is the emergence of power-law relations between population size and a variety of urban indicators, echoing allometric scaling in living organisms akin to Kleiber's law. However fascinating, existing scaling theories suffer from biases related to the ad-hoc definition of city boundaries and to their neglect of intraurban variability of city properties. Here, to deal rigorously with biases, we explore the hypothesis that the empirical statistics of intrac...
• Quantum spin liquid from electron-phonon coupling AI翻译
  作者：Cai, Xun; Han, Zhaoyu; Li, Zi-Xiang; Kivelson, Steven A.; Yao, Hong
  作者单位：Chinese Academy of Sciences; Institute of Physics, CAS; Stanford University; Tsinghua University
  摘要：A quantum spin liquid (QSL) is an exotic insulating phase with emergent gauge fields and fractionalized excitations. However, the unambiguous demonstration of the existence of a QSL in a nonengineered microscopic model (or in any material) remains challenging. Here, using numerically exact sign-problem-free quantum Monte Carlo simulations, we show that a QSL arises in a nonengineered electron-phonon model. Specifically, we investigate the ground-state phase diagram of the bond Su-Schrieffer-He...
• Familial transmission of neural representations for mental arithmetic across two generations AI翻译
  作者：Constant-Varlet, Charlotte; Nakai, Tomoya; Longo, Lea; Bouchet, Honorine; Prado, Jerome
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Claude Bernard Lyon 1; Universite Jean Monnet; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Humanities & Social Sciences (INSHS); Universite Paris Cite
  摘要：Parental skills are among the most powerful predictors of children's outcomes. While distal genetic and environmental pathways likely contribute to skill transmission within families, much less is known about the proximal neural markers that support the transmission of cognitive functioning from parents to children. It is also unclear whether brain similarity between parents and children predicts similarity in cognitive skills. In this study, we used fMRI to measure brain activity associated w...