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作者：Samir, Sherihan; Elshereef, Abdalla A.; Alva, Vikram; Hahn, Jeanette; Eck, Frederik; Celma, Louisa; Lopes, Eduardo S.; Thormann, Kai; Dubnau, David; Galperin, Michael Y.; Selim, Khaled A.
作者单位：Eberhard Karls University of Tubingen; Egyptian Knowledge Bank (EKB); Ain Shams University; Egyptian Knowledge Bank (EKB); National Research Centre (NRC); Max Planck Society; Rutgers University System; Rutgers University Newark; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University System; Rutgers University Newark; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Justus Liebig University Giessen; Heinrich Heine University Dusseldorf; National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM); Division of Intramural Research (DIR)
摘要：Cyclic dimeric-GMP (c-di-GMP) is a ubiquitous bacterial second messenger that regulates a variety of cellular processes, including motility, biofilm formation, secretion, cell cycle progression, and development, and also contributes to the virulence of many bacterial pathogens. While the genes encoding c-di-GMP cyclases and hydrolases are readily identifiable in microbial genomes, known c-di-GMP receptor domains are quite few, with only PilZ and MshEN broadly distributed across bacterial phyla...
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作者：Gkragkopoulou, Polyniki; Garrett, Stephen R.; Shah, Prakhar Y.; Grebenc, Dirk W.; Klein, Timothy A.; Kim, Youngchang; Whitney, John C.
作者单位：McMaster University; McMaster University; United States Department of Energy (DOE); Argonne National Laboratory; McMaster University
摘要：To survive in highly competitive environments, bacteria use specialized secretion systems to deliver antibacterial toxins into neighboring cells, thereby inhibiting their growth. In many Gram-positive bacteria, the export of such toxins requires a membrane-bound molecular apparatus known as the type VIIb secretion system (T7SSb). Recently, it was shown that toxin recruitment to the T7SSb requires a physical interaction between a toxin and two or more so-called targeting factors, which harbor k...
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作者：Hagerman, Paul J.
作者单位：University of California System; University of California Davis
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作者：Ardhuin, Fabrice; Postec, Taina; Accensi, Mickael; Piolle, Jean-Francois; Dodet, Guillaume; Passaro, Marcello; De Carlo, Marine; Husson, Romain; Guitton, Gilles; Collard, Fabrice
作者单位：Universite de Bretagne Occidentale; Ifremer; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); Institut Universitaire Europeen de la Mer (IUEM); Technical University of Munich
摘要：Winds generate waves over the oceans with a wide range of properties. The largest wave heights and periods are important parameters in the design of marine structures. Extreme waves also play an outsize role in air-sea fluxes and coastal dynamics, and leave imprints on seismic and sediment records. Rare events have so far escaped measurements, with few wave heights from satellite altimeters exceeding 16 m, and no associated measurement of wave periods. Here, we use swells radiated from storms ...
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作者：Gervais, Will M.; McKay, Ryan T.; Brown-Iannuzzi, Jazmin L.; Ross, Robert M.; Pennycook, Gordon; Jong, Jonathan; Lanman, Jonathan A.
作者单位：Brunel University; University of London; Royal Holloway University London; University of Virginia; Macquarie University; Cornell University; Coventry University; Queens University Belfast
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作者：Hazime, Khodor S.; Sheppard, Sam; Niembro-Vivanco, Olatz; Hosty, Cathal; Thomas, Heather; Loosbroock, Christopher; Peiser, Leanne; Davis, Daniel M.
作者单位：Imperial College London; University of Manchester; Bristol-Myers Squibb
摘要：Engagers are antibody-based therapies which bind immune cell receptors and a target cell ligand. Next-gen engagers typically bind two activating receptors, but the effect of this on immune synapse formation and signaling is unknown. Here, we coligated activating receptors CD16a and NKG2D on natural killer (NK) cells with a CD33-binding anti-acute myeloid leukemia (AML) engager. Superresolution microscopy revealed that coligating CD16a and NKG2D with a single molecule triggered their nanoscale ...
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作者：Wagih, Malik; Naunheim, Yannick; Lei, Tianjiao; Schuh, Christopher A.
作者单位：Massachusetts Institute of Technology (MIT); United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Northwestern University
摘要：Tailoring the nanoscale distribution of chemical species at grain boundaries is a powerful method to dramatically influence the properties of polycrystalline materials. However, classical approaches to the problem have tacitly assumed that only competition is possible between solute species. In this paper, we show that solute elements can cooperate in the way they segregate to grain boundaries: In properly targeted alloys, the different chemical species cooperate to each fill complementary gra...
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作者：Tsubery, Yehonatan; Aharoni, Hillel
作者单位：Weizmann Institute of Science
摘要：Topological defects, such as disclination lines in nematic liquid crystals, are fundamental to many physical systems and applications. In this work, we study the behavior of nematic disclinations in thin parallel-plate geometries with strong patterned planar anchoring. Building on prior models, we solve both the forward problem-predicting disclination trajectories from given surface patterns-and an extended inverse problem-designing surface patterns to produce a tunable family of disclination ...
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作者：Ritt, Daniel A.; Durrant, David E.; Drew, Matthew R.; Sandin, Suzanne I.; Fiesco, Juliana A. Martinez; Zhang, Xiaohua; Aydin, Fikret; Carpenter, Timothy S.; Scheidemantle, Grace M.; D'Ippolito, Robert A.; Sohn, Alexandria L.; Dehart, Caroline J.; Shrestha, Rebika; Snead, Kelly; Hull, Jenna; Tempkin, Jeremy O. B.; Yang, Yue; Lightstone, Felice C.; Streitz, Frederick H.; Zhang, Ping; Turbyville, Thomas J.; Stephen, Andrew G.; Esposito, Dominic; Ingolfsson, Helgi I.; Nissley, Dwight, V; Morrison, Deborah K.
作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); United States Department of Energy (DOE); Lawrence Livermore National Laboratory
摘要：The RAF kinases (ARAF, BRAF, and CRAF) are essential components of the RAS-ERK signaling pathway, which controls vital cellular processes and is frequently dysregulated in human disease. Notably, mutations that alter BRAF function are prominent drivers of human cancer and certain RASopathy disorders, making BRAF an important target for therapeutic intervention. Despite extensive research, several aspects of BRAF regulation remain unclear. In this study, we developed an in vitro BRAF activation...
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作者：Collins, Scott L.
作者单位：University of New Mexico
