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作者：Hong, Sixing; Guan, Zeyuan; Zhang, Liying; Zhuang, Jinjin; Yan, Ling; Liu, Yanjun; Liu, Zhu; Wang, Qiang; Yin, Ping
作者单位：Huazhong Agricultural University; Hubei Hongshan Laboratory
摘要：Prohibitin 1 (PHB1) and Prohibitin 2 (PHB2), two conserved prohibitin members, are primarily localized to the mitochondrial inner membrane (MIM) to form a nanoscale macromolecular prohibitin complex. This prohibitin complex can facilitate the spatial organization of proteins and lipids, thus maintaining cellular metabolism and homeostasis, but its architecture remains largely unknown. Here, we report the cryo- EM structure of a prohibitin complex at 2.8 & Aring; resolution, which contains 11 P...
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作者：Tobias, Joseph A.; Bullock, James M.; Dicks, Lynn V.; Forester, Brenna R.; Razgour, Orly
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作者：Swingle, Kelsey L.; Hamilton, Alex G.; Han, Xuexiang; Liao, Kuo - Chieh; Safford, Hannah C.; Thatte, Ajay S.; Geisler, Hannah C.; Xu, Junchao; Saw, Tzuen Yih; Wan, Yue; Mitchell, Michael J.
作者单位：University of Pennsylvania; Agency for Science Technology & Research (A*STAR); A*STAR - Genome Institute of Singapore (GIS); University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania
摘要：With the advent and widespread use of messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), RNA vaccines have emerged as an exciting class of vaccine offering low cost, rapid development, and high modularity and manufacturability. Protein-coding circular RNA (circRNA) is an emerging class of RNA cargo that offers increased stability compared to mRNA with potentially reduced immunogenicity, but delivery technologies for intracellular delivery of cir...
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作者：Brott, Barbara K.; Raissi, Aram J.; Micheva, Kristina D.; Vielmetter, Jost; Mendes, Monique S.; Baccus, Caroline J.; Huang, Jolie; Shatz, Carla J.
作者单位：Stanford University; Stanford University; Stanford Medicine; Stanford University; California Institute of Technology
摘要：Synapse pruning sculpts neural circuits throughout life. The human Leukocyte immunoglobulin-like receptor type B2 (LilrB2)/murine Paired immunoglobulin receptor B (PirB) receptors expressed in neurons and complement protein C4 have been separately implicated in pruning. Here, we report that C4d, a C4 cleavage product with unknown function, binds LilrB2/PirB with nanomolar affinity. C4d and LilrB2 colocalize at excitatory synapses in the human cerebral cortex as well as with beta amyloid in Alz...
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作者：Mausz, Michaela A.; Murphy, Andrew R. J.; Ferretjans, Maria del Mar Aguilo-; Hitchcock, Andrew; Moran, Mary Ann; Scanlan, David J.; Chen, Yin; Lidbury, Ian D. E. A.
作者单位：University of Warwick; University of Sheffield; University of Sheffield; University System of Georgia; University of Georgia; University of Birmingham
摘要：Across all domains of life, cobalamin-dependent methyltransferases have diversified to perform a range of crucial functions, such as methionine synthesis and the demethylation of various reduced nitrogen and sulfur compounds. These large modular enzymes typically possess three substrate-binding domains, two binding either the methyl donor or methyl acceptor, as well as a cobalamin-binding domain. Here, by challenging the current paradigm of glycine betaine (GBT) catabolism, we have identified ...
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作者：Hong, Hu; Wei, Zhiquan; Wang, Yiqiao; Yang, Xinru; Guo, Xun; Nian, Qingshun; Li, Xinliang; Li, Qing; Wang, Shixun; Li, Shimei; Zhang, Dechao; Xiong, Qi; Huang, Zhaodong; Zhi, Chunyi
作者单位：City University of Hong Kong; The University of Hong Kong Shenzhen Institute of Research & Innovation; University of Hong Kong; University of Hong Kong; Zhengzhou University; University of Macau; University of Hong Kong; University of Hong Kong
摘要：Solid-state electrolytes (SSEs) are being extensively researched as replacements for liquid electrolytes in future batteries. Despite significant advancements, there are still challenges in using SSEs, particularly in extreme conditions. This study presents a hydrated metal-organic ionic cocrystal (HMIC) solid-state ion conductor with a solvent-assisted ion transport mechanism suitable for extreme operating conditions. Through crystal engineering strategies, the adsorption capacity of HMIC for...
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作者：Abdellaoui, Abdel; Wesseldijk, Laura W.; Gordon, Scott D.; Smit, Dirk J. A.; Androvicova, Renata; Martin, Nicholas G.; Ullen, Fredrik; Mosing, Miriam A.; Zietsch, Brendan P.; Verweij, Karin J. H.
作者单位：University of Amsterdam; Karolinska Institutet; University of Melbourne; QIMR Berghofer Medical Research Institute; Karolinska Institutet; National Institute of Mental Health - Czech Republic; University of Queensland
摘要：Romantic (typically sexual) relationships are important to personal, physical, mental, social, and economic well-being, and to human evolution. Yet little is known about factors contributing to long-term lack of intimate relationships. We investigated phenotypic and genetic correlates of never having had sex in similar to 400,000 UK residents aged 39 to 73 and similar to 13,500 Australian residents aged 18 to 89. The strongest associations revealed that sexless individuals were more educated, ...
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作者：Dong, Junkai; Sommer, Ophelia Evelyn; Soejima, Tomohiro; Parker, Daniel E.; Vishwanath, Ashvin
作者单位：Harvard University; University of California System; University of California San Diego
摘要：Recent advances in 2D materials featuring nonzero Berry curvature have inspired extensions of the Wigner crystallization paradigm. This paper derives a low-energy effective theory for such quantum crystals, including the anomalous Hall crystal (AHC) with nonzero Chern number. First, we show that the low frequency dispersion of phonons in AHC, despite the presence of Berry curvature, resembles that of the zero field (rather than finite magnetic field) Wigner crystal due to the commutation of tr...
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作者：Whitridge, Peter
作者单位：Memorial University Newfoundland
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作者：Yuan, Yichuan; Niu, Yi; Huang, Zhenkun; Shi, Yunxing; Lin, Zhu; Zuo, Dinglan; Zhong, Chengrui; Li, Kai; Guan, Xin - Yuan; Yuan, Yunfei; Li, Binkui
作者单位：Sun Yat Sen University; State Key Lab Oncology South China; Sun Yat Sen University; University of Hong Kong
摘要：Hepatocellular carcinoma (HCC) frequently develops resistance to CD8+ T cell-based immunotherapy, yet the mechanisms driving this immune evasion remain poorly understood. To identify tumor-intrinsic regulators of immunotherapy resistance and explore therapeutic strategies to restore T cell-mediated tumor control, we employed three functional genomics approaches using in vitro and in vivo CRISPR screening. Cancer USP14 was identified as the critical immune evasion driver. USP14-high HCC patient...
