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作者：Halder, Sebok K.; Delorme-Walker, Violaine D.; Milner, Richard
摘要：The blood-brain barrier (BBB) is critical for maintaining cerebral homeostasis, and its deterioration with age is an important pathogenic factor in the etiology of vascular dementia. Extracellular matrix-integrin interactions play a central role in regulating vascular stability.The alpha v beta 3 integrin is not expressed by brain endothelial cells under stable conditions but is strongly induced by hypoxia. However, it is currently unclear whether alpha v beta 3 integrin exerts a destructive o...
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作者：Hung, Hsiao-chun; Deng, Zhenhua; Liu, Yiheng; Ran, Zhiyu; Zhang, Yue; Li, Zhen; Kaifu, Yousuke; Huang, Qiang; Nguyen, Khanh Trung Kien; Le, Hai Dang; Xie, Guangmao; Nguyen, Anh Tuan; Yamagata, Mariko; Simanjuntak, Truman; Noerwidi, Sofwan; Fauzi, Mohammad Ruly; Tolla, Marlin; Wetipo, Alpius; He, Gang; Sawada, Junmei; Zhang, Chi; Bellwood, Peter; Matsumura, Hirofumi
作者单位：Australian National University; Peking University; Peking University; University of Tokyo; Guangxi Normal University; Rikkyo University; National Research & Innovation Agency of Indonesia (BRIN); Niigata University of Health & Welfare; Australian National University; Sapporo Medical University
摘要：In southern China and Southeast Asia (collectively, Southeastern Asia), Terminal Pleistocene and Early to Middle Holocene (ca. 12,000 to 4,000 cal. BP) hunter-gatherer burials feature tightly crouched or squatting postures, sometimes with indications of post-mortem dismemberment. Such burials contrast strongly with the extended supine burial postures typical of subsequent Neolithic inhumations in these regions. Their contorted postures, often with traces of burning, present interpretive challe...
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作者：Karakas, Danielle; Li, June; Ma, Wenjing; Wu, Xun Grace; Khoury, Christopher J.; Masoud, Mina; Hoard, Brock; Liu, Yuning Jay; Zhu, Guangheng; Chen, Junmei; Sim, Martha; Shen, Chuanbin; MacParland, Sonya A.; Lopez, Jose A.; Kahr, Walter H. A.; Ni, Heyu
作者单位：University of Toronto; University of Toronto; Saint Michaels Hospital Toronto; University of Toronto; Canadian Blood Services; University of Washington; University of Washington Seattle; Ocean University of China; University of Toronto; University Health Network Toronto; University of Toronto; University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto
摘要：Thrombopoietin (TPO), predominantly produced by the liver, is the key regulator for platelet production and the hematopoietic stem cell niche. Our earlier report demonstrated that platelet GPIb alpha is required for hepatocellular TPO generation, which is the major resource of TPO in the blood circulation. However, how hepatocytes physically contact circulating sinusoidal platelets across the liver endothelium for this process is unknown. Kupffer cells reside in contact with both sinusoidal bl...
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作者：Yao, McKenna Loop; Zill, Nicholas A.; Barber, Colin Charles; Du, Yongle; Lin, Peijun; Zhai, Rui; Yoon, Eunice; Al Marzooqi, Dunya; Zhang, Wenjun
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作者：Yoshida, Aiko; Uekusa, Yoshitsugu; Suzuki, Takeshi; Bauer, Michael; Sakai, Nobuaki; Yamauchi, Yohei
作者单位：Novo Nordisk; Hokkaido University; Olympus Corporation; Nagoya University; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich; University of Bristol; University of West England
摘要：Influenza A virus (IAV) entry into host cells begins with interactions between the viral envelope proteins hemagglutinin (HA)/neuraminidase (NA) and sialic acid moieties on the cell plasma membrane. These interactions drive IAV's lateral diffusion along the cell membrane and trigger membrane morphological changes required for endocytosis. However, directly visualizing these dynamic processes, which are crucial for IAV entry, has been challenging using conventional microscopy techniques. In thi...
