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作者：Bragado, Laureano; Pozzi, Berta; Beckerman, Ines; Magalnik, Melina; Srebrow, Anabella
作者单位：University of Buenos Aires; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University of Buenos Aires
摘要：The noncoding small nuclear RNAs (snRNAs) associate with a large set of proteins to form small nuclear ribonucleoprotein particles (snRNPs). While the function of snRNAs is well characterized, the regulation of their transcription remains poorly understood. Recently, we demonstrated that SUMO conjugation regulates snRNA3 ' end processing. To further study the connection between SUMOylation and snRNA biogenesis, we generated a CRISPR/dCas9 tool comprising a catalytically inactive Cas9 (dCas9) f...
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作者：Chuang, Po-Kai; Chung, Cinya; Liao, Kuo-Shiang; Wong, Chi-Huey
作者单位：Scripps Research Institute; National Sun Yat Sen University; Kaohsiung Medical University; Kaohsiung Medical University Hospital; Academia Sinica - Taiwan
摘要：Pancreatic cancer remains one of the most lethal malignancies with limited therapeutic options. Among the alternative targets explored for pancreatic cancer, the glycolipid stage-specific embryonic antigen-4 (SSEA4) has been extensively studied. We have previously demonstrated that the chimeric anti-SSEA4 antibody with alpha-2,6-sialylated complex type biantennary glycan (SCT) or its 3-fluorosialyl derivative (FSCT) attached to the Fc-Asn297 residue exhibited enhanced binding to the Fc-recepto...
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作者：Chen, Zhengyun; Lian, Justin Z.; Huang, Haozhou; Zhu, Hengyi; Kanye, Lynda Thubelihle; Chen, Mateng; Zhang, Zhihao; Liu, Boxin; Zhang, Jiawei; Ahmed, Ajaz; Barbarossa, Valerio; Cucurachi, Stefano; Dong, Bin
作者单位：China Pharmaceutical University; Leiden University; Leiden University - Excl LUMC; New York University; China Pharmaceutical University; China Pharmaceutical University; Imperial College London; University of California System; University of California Los Angeles; China Pharmaceutical University
摘要：This study presents a comparative cradle-to-gate environmental and economic evaluation of nine synthetic routes for Molnupiravir (EIDD-2801), a broad-spectrum antiviral drug. Integrating Life Cycle Assessment (LCA) with Life Cycle Costing (LCC), we quantified the environmental impacts alongside capital and operational costs, net present costs, and break-even prices of each route. The results reveal significant variation across the schemes, with Schemes #1 and #2 exhibiting the highest impacts ...
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作者：Hung, Hsiao-chun; Deng, Zhenhua; Liu, Yiheng; Ran, Zhiyu; Zhang, Yue; Li, Zhen; Kaifu, Yousuke; Huang, Qiang; Nguyen, Khanh Trung Kien; Le, Hai Dang; Xie, Guangmao; Nguyen, Anh Tuan; Yamagata, Mariko; Simanjuntak, Truman; Noerwidi, Sofwan; Fauzi, Mohammad Ruly; Tolla, Marlin; Wetipo, Alpius; He, Gang; Sawada, Junmei; Zhang, Chi; Bellwood, Peter; Matsumura, Hirofumi
作者单位：Australian National University; Peking University; Peking University; University of Tokyo; Guangxi Normal University; Rikkyo University; National Research & Innovation Agency of Indonesia (BRIN); Niigata University of Health & Welfare; Australian National University; Sapporo Medical University
摘要：In southern China and Southeast Asia (collectively, Southeastern Asia), Terminal Pleistocene and Early to Middle Holocene (ca. 12,000 to 4,000 cal. BP) hunter-gatherer burials feature tightly crouched or squatting postures, sometimes with indications of post-mortem dismemberment. Such burials contrast strongly with the extended supine burial postures typical of subsequent Neolithic inhumations in these regions. Their contorted postures, often with traces of burning, present interpretive challe...
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作者：Karakas, Danielle; Li, June; Ma, Wenjing; Wu, Xun Grace; Khoury, Christopher J.; Masoud, Mina; Hoard, Brock; Liu, Yuning Jay; Zhu, Guangheng; Chen, Junmei; Sim, Martha; Shen, Chuanbin; MacParland, Sonya A.; Lopez, Jose A.; Kahr, Walter H. A.; Ni, Heyu
作者单位：University of Toronto; University of Toronto; Saint Michaels Hospital Toronto; University of Toronto; Canadian Blood Services; University of Washington; University of Washington Seattle; Ocean University of China; University of Toronto; University Health Network Toronto; University of Toronto; University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto
摘要：Thrombopoietin (TPO), predominantly produced by the liver, is the key regulator for platelet production and the hematopoietic stem cell niche. Our earlier report demonstrated that platelet GPIb alpha is required for hepatocellular TPO generation, which is the major resource of TPO in the blood circulation. However, how hepatocytes physically contact circulating sinusoidal platelets across the liver endothelium for this process is unknown. Kupffer cells reside in contact with both sinusoidal bl...
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作者：Yoshida, Aiko; Uekusa, Yoshitsugu; Suzuki, Takeshi; Bauer, Michael; Sakai, Nobuaki; Yamauchi, Yohei
作者单位：Novo Nordisk; Hokkaido University; Olympus Corporation; Nagoya University; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich; University of West England; University of Bristol
摘要：Influenza A virus (IAV) entry into host cells begins with interactions between the viral envelope proteins hemagglutinin (HA)/neuraminidase (NA) and sialic acid moieties on the cell plasma membrane. These interactions drive IAV's lateral diffusion along the cell membrane and trigger membrane morphological changes required for endocytosis. However, directly visualizing these dynamic processes, which are crucial for IAV entry, has been challenging using conventional microscopy techniques. In thi...
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作者：Hwang, Gayoung; Yang, Dae-Wook; Geisseova, Terezia Klaudia; Kim, Hae A.; Oh, Yangkyun; Suh, Greg S. B.
作者单位：Korea Advanced Institute of Science & Technology (KAIST); Ulsan National Institute of Science & Technology (UNIST); Korea Advanced Institute of Science & Technology (KAIST); Ewha Womans University
摘要：In an ever- changing environment, animals make optimal decisions to ensure their nutrients they require to maintain homeostasis. Under extreme circumstances (e.g., infection), they may exhibit ingestive behaviors, such as seeking out substances (e.g., toxins) that suggest self- medication. Few studies, however, have investigated the mechanisms that ensue self- medication. Here, we report the selective intake of antioxidants by Drosophila melanogaster during a period of heat stress or sleep dep...
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作者：Lynch, Elizabeth A.; Calcote, Randy; Zabinski, Catherine A.; Hotchkiss, Sara C.
作者单位：University of Minnesota System; University of Minnesota Twin Cities; Montana State University System; Montana State University Bozeman; University of Wisconsin System; University of Wisconsin Madison
摘要：Margaret Bryan Davis, a prominent ecologist, died on May 22, 2024. She was a Regents Professor at the University of Minnesota and a member of the National Academy of Sciences. Her students remember her as a creative and clear-thinking scientist who combined the tools and perspectives of paleoecology with ideas and problems of ecology in order to understand long-term forest dynamics. She was a champion of diversity and equity in science.
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作者：Saglimbeni, Joseph; Esteva, Eduardo; Canales, Josue; Perez, Oriana A.; Eichinger, Anna; Huntley, William; Khanna, Kamal M.; Dolgalev, Igor; Klar, Natalie; Adams, Sylvia; Reizis, Boris
作者单位：New York University; New York University; New York University; University of Munich; New York University; New York University
摘要：Breast tumors harbor dynamic microenvironments, with multiple immune cell types playing opposing roles during tumor progression and/or response to therapy. Tumor- associated macrophages promote mammary tumorigenesis, whereas the role of mammary tissue macrophages (MTMs) remains incompletely understood. High- dimensional immunostaining of murine mammary tumor progression revealed that MTMs were localized in the peritumoral stroma and associated with eosinophils, which were previously shown to f...
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作者：Quillien, Tadeg
作者单位：University of Edinburgh
