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作者：Kubatova, Nina; Schmidt, Thomas; Wang, Quan; Clore, G. Marius
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
摘要：G protein-coupled receptors (GPCRs) comprise a large class of membrane proteins that mediate cellular responses to a wide range of external signals and as such constitute major drug targets. While oligomerization has been shown to play a well-established role in modulating signaling for class C GPCRs (e.g., the glutamate and GABA receptors), the functional relevance of oligomerization for class A receptors, such as the beta(1)-adrenergic receptor (beta(1)AR), remains unclear. Here, we have exa...
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作者：Zhou, Yu; Wei, Chen; Jin, Lihua
作者单位：University of California System; University of California Los Angeles
摘要：Liquid crystal elastomers (LCEs) are anisotropic, viscoelastic materials integrating polymer networks and liquid crystals. While their mechanical responses have been extensively studied, their fracture behavior remains largely unexplored. Specifically, the effect of the deformation-director coupling on LCE fracture paths is unknown, and fracture criteria for LCEs are not yet established. To address this gap, we combine experimental and theoretical approaches to investigate fracture propagation...
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作者：Quillien, Tadeg
作者单位：University of Edinburgh
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作者：Sharan, Deepti; Nurek, Agnieszka; Stemczynski, Joshua; Turan, Kristof; Little, Alexander S.; Coyne, Michael J.; McMillin, Mary; Sidebottom, Ashley M.; Comstock, Laurie E.; Light, Samuel H.
作者单位：University of Chicago; University of Chicago
摘要：The human gut microbiome plays a central role in nutrient metabolism, yet the fate of exogenous nucleic acids within this ecosystem remains poorly understood. Here, we show that multiple Bacteroidales species efficiently metabolize exogenous DNA, with Bacteroides thetaiotaomicron converting it into the deaminated nucleobases uracil and xanthine. Using genetic and biochemical approaches, we identify ddbABCDEF, a six-gene locus encoding secreted nucleases and an outer membrane transporter, essen...
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作者：Snow, Meradeth; Searcy, Michael T.; Summers, Rachel; Blohm, Tre; Hazelwood, Lacy; McDonald, Holli; Jensen, Samuel J.; Punzo-Diaz, Jose Luis
作者单位：University of Montana System; University of Montana; Brigham Young University; University of Oklahoma System; University of Oklahoma - Norman
摘要：The Casas Grandes region in northwest Chihuahua, Mexico, is ideally situated to explore the notion of contact between the US Southwest/Northwest Mexico and Mesoamerica, as it lies geographically in a region where cultural traditions were combined in unique ways. In order to explain these dynamics, past researchers have suggested that the primary catalyst for the flourishing Casas Grandes population in the thirteenth century A.D. was caused by migrants from Mesoamerica or from larger population...
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作者：Kanai, Ryuta; Tsunekawa, Naoki; Cornelius, Flemming; Vilsen, Bente; Toyoshima, Chikashi
作者单位：University of Tokyo; Aarhus University
摘要：Palytoxin (PTX), a potent marine toxin, has long been known to transform Na+,K+- ATPase (NKA), an indispensable ion pump, into a nonselective cation channel. It has been postulated that PTX takes control of the two gates on either side of a channel-like pore. These gates normally open and close alternately, synchronized with chemical events, never opening simultaneously. A critical question is whether palytoxin takes over the control of the two gates or creates a new pathway. Here, we present ...
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作者：Alber, Daniel S.; Zhao, Shiheng; Jacinto, Alexandre O.; Wieschaus, Eric F.; Shvartsman, Stanislav Y.; Haas, Pierre A.
作者单位：Princeton University; Princeton University; Max Planck Society; Max Planck Society; Simons Foundation; Flatiron Institute; Princeton University
摘要：Tissue deformations during morphogenesis can be active, driven by internal processes, or passive, resulting from stresses applied at their boundaries. Here, we introduce the Drosophila hindgut primordium as a model for studying boundary-driven tissue morphogenesis. We characterize its deformations and show that its complex shape changes can be a passive consequence of the deformations of the active regions of the embryo that surround it. First, we find an intermediate characteristic triangular...
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作者：Filatova, Tatiana; Akkerman, Joos; Bosello, Francesco; Chatzivasileiadis, Theodoros; Ghorbani, Amineh; Ivanova, Olga; Knittel, Nina; Kwakkel, Jan; Lamperti, Francesco; Magliocca, Nicholas R.; Marangoni, Giacomo; Nabernegg, Stefan; Pichler, Anton; Poujon, Adrian; Safarzynska, Karolina; Taberna, Alessandro
作者单位：Harvard University; Delft University of Technology; Centro Euro-Mediterraneo sui Cambiamenti Climatici (CMCC); University of Graz; Scuola Superiore Sant'Anna; University of Warsaw
摘要：Climate policy faces increasingly complex challenges that span multiple human decision scales in nature-society systems. Contemporary climate policy models, while valuable and increasingly versatile in handling spatial and temporal scales, struggle to capture interacting multiscale decisions on the socioeconomic side. This perspective draws attention to the power of coupling among different modeling families, taking integrated assessment models (IAM), computable general equilibrium models (CGE...
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作者：Krishnan, Shanmugarajan; Lee, Somin; Amoozgar, Zohreh; Subudhi, Sonu; Kumar, Ashwin Srinivasan; Posada, Jessica M.; Lindeman, Neal; Lei, Pinji; Duquette, Mark; Steinbuch, Sophie; Charabati, Marc; Huang, Peigen; Andersson, Patrik; Datta, Meenal; Munn, Lance L.; Fukumura, Dai; Jain, Rakesh K.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; University of Bonn; Agenus Inc; Agency for Science Technology & Research (A*STAR); A*STAR - Bioprocessing Technology Institute (BTI); Rockefeller University; Cornell University; Weill Cornell Medicine; University of Notre Dame
摘要：Wnt signaling plays a crucial role for many developmental processes. It is also pivotal in the generation and limited treatment outcomes of glioblastoma (GBM). Here, we identified Wnt7b, which is markedly upregulated in GBM patients, as a determinant of resistance to immune checkpoint blockers (alpha PD1; anti-Programmed Cell Death Protein 1) in a clinically relevant, alpha PD1-resistant GBM murine model with abundant stem cells. We observed that increased levels of Wnt7b and beta-- catenin co...
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作者：Berenbaum, May R.
