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作者：Kim, David E.; Watson, Joseph L.; Juergens, David; Majumder, Sagardip; Sonigra, Ria; Gerben, Stacey R.; Kang, Alex; Bera, Asim K.; Li, Xinting; Baker, David
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute
摘要：Francis Crick's global parameterization of coiled coil geometry has been widely useful for guiding design of new protein structures and functions. However, design guided by similar global parameterization of beta barrel structures has been less successful, likely due to the deviations from ideal barrel geometry required to maintain inter-strand hydrogen bonding without introducing backbone strain. Instead, beta barrels have been designed using two-dimensional structural blueprints; while this ...
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作者：Slaughter, Isaac; Peytavin, Axel; Ugander, Johan; Saveski, Martin
作者单位：University of Washington; University of Washington Seattle; Stanford University; Yale University
摘要：Social networks scaffold the diffusion of information on social media. Much attention has been given to the spread of true vs. false content on online social platforms, including the structural differences between their diffusion patterns. However, much less is known about how platform interventions on false content alter the engagement with and diffusion of such content. In this work, we estimate the causal effects of Community Notes, a novel fact-checking feature adopted by X (formerly Twitt...
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作者：Deike, Luc; Zhou, Xiaohui; Rustogi, Paridhi; Stanley, Rachel H. R.; Reichl, Brandon G.; Bushinsky, Seth M.; Resplandy, Laure
作者单位：Princeton University; Princeton University; Princeton University; Wellesley College; National Oceanic Atmospheric Admin (NOAA) - USA; University of Hawaii System; University of Hawaii Manoa
摘要：Bubble-mediated gas exchange associated with wave breaking is a critical pathway for ocean-atmosphere exchange of low solubility gases such as oxygen. Yet, ocean and climate models, as well as observation-based products, usually rely on wind-only air-sea flux formulations derived from carbon constraints that ignore the asymmetric nature of the bubble flux, contributing to discrepancies between estimates of oxygen inventories and their response to climate change. Without bubbles, gas exchange i...
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作者：Donati, Dante; Fong, Hortense
作者单位：Columbia University
摘要：Social media platforms have become vital channels for businesses to reach consumers through advertising. But in the United States, the digital advertising market in which these platforms operate is dominated by a few major players, raising concerns for antitrust regulators. In such a concentrated market, the entry or exit of a single platform can reallocate billions in ad spending, affecting businesses and users. TikTok's temporary suspension in the United States in January 2025 provides a uni...
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作者：Ma, Yeyang; Zhang, Qiuyuan; Li, Dekang; Zhao, Kun; Li, Zefei; Liu, Yuan; Wang, Chu; Sun, Bo; Li, Dan; Yuan, Junying; Liu, Cong
作者单位：Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Peking University; Peking University; Chinese Academy of Sciences; ShanghaiTech University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Fudan University
摘要：The canonical necrosome formed by receptor-interacting protein kinase 1 (RIPK1) and RIPK3 is a functional amyloid fibril structure critical to intracellularly drive necroptosis. Since necroptosis leads to the release of intracellular content, the fate of RIPK1/RIPK3 fibrils after necroptotic cell death has not been investigated. Here, we tracked RIPK1 and RIPK3 coassemblies and found that these fibrillar aggregates could be released into the culture medium after the membrane rupture in necropt...
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作者：Agip, Ahmed-Noor A.; Ornelas, Pamela; Yang, Tzu-Jing; Uboldi, Ermanno; Hader, Sabine; McDowell, Melanie A.; Kuhlbrandt, Werner
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作者：Beans, Carolyn
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作者：Pourhosseinzadeh, Mohammad S.; Huang, Jessica L.; Shin, Donghan; Hart, Ryan G.; Framroze, Luhaiza Y.; Guillen, Jaresley, V; Sanchez, Joel; Tirado, Ramir, V; Unanwa, Kelechi; Huising, Mark O.
作者单位：University of California System; University of California Davis; University of California System; University of California Davis
摘要：Insulin potently decreases blood glucose; thus, tight control is required to prevent excessive insulin release and hypoglycemia. Central to this inhibition is somatostatin released from delta cells that are clustered with beta cells in pancreatic islets. This communication is of interest because the loss of functional beta cells in diabetes leads to uncontrolled delta cell activity that disrupts islet paracrine crosstalk. While it is established that insulin and somatostatin secretion are coor...
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作者：Saxena, Sunil; Waldeck, David H.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
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作者：Stanhope, Sarah C.; Singhal, Kratika; Morato, Nicolas M.; Feng, Yunfei; Meng, Gaoya; Marlin, Makayla N.; Kotanko, Claudia C.; Jarrett, Madolyn M.; Mesecar, Andrew D.; Cooks, R. Graham; Weake, Vikki M.
作者单位：Purdue University System; Purdue University; Purdue University System; Purdue University; Purdue University System; Purdue University; Purdue University System; Purdue University
摘要：One- carbon metabolism influences gene expression by providing methyl units for DNA, RNA, and histone methylation. Robust methylation requires rapid hydrolysis of the (Ahcy). Ahcy is essential for maintaining methylation potential; however, the mechanisms governing its enzymatic activity, particularly in response to cellular stress, remain largely uncharacterized. Here, we show Ahcy is a redox- sensitive enzyme that is inhibited by oxidation of a conserved cysteine, C195, in vitro resulting in...
