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作者：Swingle, Kelsey L.; Hamilton, Alex G.; Han, Xuexiang; Liao, Kuo - Chieh; Safford, Hannah C.; Thatte, Ajay S.; Geisler, Hannah C.; Xu, Junchao; Saw, Tzuen Yih; Wan, Yue; Mitchell, Michael J.
作者单位：University of Pennsylvania; Agency for Science Technology & Research (A*STAR); A*STAR - Genome Institute of Singapore (GIS); University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
摘要：With the advent and widespread use of messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), RNA vaccines have emerged as an exciting class of vaccine offering low cost, rapid development, and high modularity and manufacturability. Protein-coding circular RNA (circRNA) is an emerging class of RNA cargo that offers increased stability compared to mRNA with potentially reduced immunogenicity, but delivery technologies for intracellular delivery of cir...
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作者：Kamp, Leon M.; Zanaty, Mohamed; Zareei, Ahmad; Gorissen, Benjamin; Wood, Robert J.; Bertoldi, Katia
作者单位：Harvard University; KU Leuven
摘要：Programming physical intelligence into mechanisms holds great promise for machines that can accomplish tasks such as navigation of unstructured environments while utilizing a minimal amount of computational resources and electronic components. In this study, we introduce a design approach for physically intelligent underactuated mechanisms capable of autonomously adjusting their motion in response to environmental interactions. Specifically, multistability is harnessed to sequence the motion o...
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作者：Li, Jinxi; Xiang, Ting; Zhang, Fengping; Feng, Li; Wu, Yiting; Guo, Fan; Li, Lingzhi; Fu, Ping; Ma, Liang
作者单位：Sichuan University
摘要：Kidney fibrosis is driven by multiple factors, among which impaired fatty acid oxidation has emerged as a critical determinant. Acyl-Coenzyme A (CoA) synthetase medium-chain family member 3 (ACSM3), a key enzyme of medium-chain fatty acid (MCFA) metabolism, has been implicated in metabolic syndrome, but its function in fibrotic kidney remains unexplored. Here, we found that tubular epithelial ACSM3 expression was downregulated in kidney fibrotic mice and patients and inversely correlated with ...
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作者：Samim, Saini; Dalton, Hayden; Phillips, David; Hergt, Janet
作者单位：University of Melbourne
摘要：The Turkana Basin is a renowned paleoanthropological region in Kenya and Ethiopia and is famous for discoveries of numerous hominin fossils and their associated cultural technologies. The Plio-Pleistocene sedimentary sequences hosting these important remains are interbedded with volcanic ash (tuff) beds that provide crucial bracketing age constraints. The Nariokotome Tuff Complex, comprising the Upper, Middle, and Lower Nariokotome Tuffs, preserves deposits that cover an important time interva...
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作者：Ardhuin, Fabrice; Postec, Taina; Accensi, Mickael; Piolle, Jean-Francois; Dodet, Guillaume; Passaro, Marcello; De Carlo, Marine; Husson, Romain; Guitton, Gilles; Collard, Fabrice
作者单位：Ifremer; Universite de Bretagne Occidentale; Institut Universitaire Europeen de la Mer (IUEM); Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Technical University of Munich
摘要：Winds generate waves over the oceans with a wide range of properties. The largest wave heights and periods are important parameters in the design of marine structures. Extreme waves also play an outsize role in air-sea fluxes and coastal dynamics, and leave imprints on seismic and sediment records. Rare events have so far escaped measurements, with few wave heights from satellite altimeters exceeding 16 m, and no associated measurement of wave periods. Here, we use swells radiated from storms ...
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作者：Agip, Ahmed-Noor A.; Ornelas, Pamela; Yang, Tzu-Jing; Uboldi, Ermanno; Hader, Sabine; McDowell, Melanie A.; Kuhlbrandt, Werner
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作者：Gavris, Georgios Barkoulis; Sun, WaiChing
作者单位：Columbia University
摘要：Inferring accurate and precise material models necessary for high-fidelity predictions has been a central challenge in constitutive modeling. Both traditional regression methods and modern machine-learning approaches require specialized data labels, which often cannot be sufficiently obtained from experiments. This data demand makes many sophisticated models impractical for real-world problems. Improvements in digital image correlation techniques have enabled accurate measurements of displacem...
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作者：Lee, James; Manon, Victor; Chen, Jue
作者单位：Rockefeller University; Howard Hughes Medical Institute
摘要：In the host-pathogen arms race, herpesviruses and poxviruses encode proteins that sabotage the transporter associated with antigen processing (TAP), thereby suppressing MHC-I antigen presentation and enabling lifelong infection. Of the five known viral TAP inhibitors, only the herpes simplex virus (HSV) protein ICP47 has been structurally resolved. We now report cryoelectron microscopy structures of TAP in complex with the remaining four: BNLF2a (Epstein-Barr virus), hUS6 (human cytomegaloviru...
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作者：Wang, Danyang; Chavas, Daniel R.; Schenkel, Benjamin A.
作者单位：Purdue University System; Purdue University; University of Oklahoma System; University of Oklahoma - Norman; National Oceanic Atmospheric Admin (NOAA) - USA; University of Oklahoma System; University of Oklahoma - Norman
摘要：Tropical cyclones are expected to intensify more rapidly with warming, but relatively little work has examined whether they could expand more rapidly with warming, too. Recent theory predicts that peak expansion rate should increase with sea surface temperature (SST), and physical arguments suggest this dependence should be specifically on the relative SST, i.e. the SST difference from the tropical mean. We test this hypothesis with historical observational data, in which SST variations are pr...
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作者：Holleman, Ethan; Catley, Thomas E.; Sereiva, Tadas; Hartono, Stella R.; Pyne, Alice L. B.; Chedin, Frederic
作者单位：University of California System; University of California Davis; University of Sheffield
摘要：R-loops are an important class of non-B DNA structures that form co-transcriptionally. Using in vitro transcription and unbiased quantitative sequencing readouts, we show that the addition of single-strand DNA binding proteins co-transcriptionally can drive a 3-to 5-fold increase of R-loop frequencywithout significant changes to R-loop distribution. We propose that this is caused by stabilizing and preventing the collapse of short nascent R-loops. This suggests that R-loop formation is highly ...
