2025

最新文章

• Water- directed pinning is key to tau prion formation AI翻译
  作者：Vigers, Michael P.; Lobo, Samuel; Najafi, Saeed; Dubose, Austin; Tsay, Karen; Ganguly, Pritam; Longhini, Andrew P.; Jin, Yingying; Buratto, Steven K.; Kosik, Kenneth S.; Shell, M. Scott; Shea, Joan-Emma; Han, Songi
  作者单位：University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; Northwestern University
  摘要：Tau forms fibrillar aggregates that are pathological hallmarks of a family of neurodegenerative diseases known as tauopathies. The synthetic replication of disease- specific fibril structures is a critical gap for developing diagnostic and therapeutic tools. This study debuts a strategy of identifying a critical and minimal folding motif in fibrils characteristic of tauopathies and generating seeding- competent fibrils from the isolated tau peptides. The 19- residue jR2R3 peptide (295 to 313) ...
• Methodological and conceptual considerations of the TCM evolution AI翻译
  作者：Wang, Haiyan; Wang, Yanbing
  作者单位：Beijing University of Chinese Medicine; Boston University
• Evolutionary feedbacks for Drosophila aggression revealed through experimental evolution AI翻译
  作者：Girardeau, Anna R.; Enochs, Grace E.; Saltz, Julia B.
  作者单位：Rice University
  摘要：Evolutionary feedbacks occur when evolution in one generation alters the environment experienced by subsequent generations and are an expected result of indirect genetic effects (IGEs). Hypotheses abound for the role of evolutionary feedbacks in climate change, agriculture, community dynamics, population persistence, social interactions, the genetic basis of evolution, and more, but evolutionary feedbacks have rarely been directly measured experimentally, leaving open questions about how feedb...
• Dopamine induces fear extinction by activating the reward-responding amygdala neurons AI翻译
  作者：Zhang, Xiangyu; Flick, Katelyn; Rizzo, Marianna; Pignatelli, Michele; Tonegawa, Susumu
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); University of Parma; Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute
  摘要：The extinction of conditioned fear responses is crucial for adaptive behavior, and its impairment is a hallmark of anxiety disorders such as posttraumatic stress disorder. Fear extinction takes place when animals form a new memory that suppresses the original fear memory.In the case of context-dependent fear memory, the new memory is formed within the reward-responding posterior subset of basolateral amygdala (BLA) that is genetically marked by Ppp1r1b+ neurons. These memory engram cells suppr...
• The POLγ Y951N patient mutation disrupts the switch between DNA synthesis and proofreading, triggering mitochondrial DNA instability AI翻译
  作者：Forslund, Josefin M. E.; Nguyen, Tran V. H.; Parkash, Vimal; Berner, Andreas; Goffart, Steffi; Wanrooij, Paulina H.; Johansson, Erik; Wanrooij, Sjoerd
  作者单位：Umea University; University of Eastern Finland
  摘要：Mitochondrial DNA (mtDNA) stability, essential for cellular energy production, relies on DNA polymerase gamma (POL gamma). Here, we show that the POL gamma Y951N disease-causing mutation induces replication stalling and severe mtDNA depletion. However, unlike other POL gamma disease-causing mutations, Y951N does not directly impair exonuclease activity and only mildly affects polymerase activity. Instead, we found that Y951N compromises the enzyme's ability to efficiently toggle between DNA sy...
• Kuznets' tides: An archaeological perspective on the long-term dynamics of sustainable development AI翻译
  作者：Green, Adam S.; Feinman, Gary M.; Thompson, Amy E.; Cruz, Pablo; Chirikure, Shadreck; Kerig, Tim; Lawrence, Dan; Petrie, Cameron A.; Ortman, Scott G.
  作者单位：University of York - UK; University of York - UK; Field Museum of Natural History (Chicago); University of Texas System; University of Texas Austin; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University of Oxford; University of Kiel; Durham University; University of Cambridge; University of Colorado System; University of Colorado Boulder
  摘要：Understanding the relationship between inequality and economicgrowth is a critical science problem that hinders sustainable development. In 1955, Simon Kuznets hypothe sized that rising economicgrowth raises inequality, which levels off as that growth continues. Kuznets'curve, which is a cornerstone of development economics, was based on data from a small sample of rich capitalist economies. Here, we draw on the GINI database, which includes area measurements of 53,464 residences from 1,176 se...
• The don't eat me signal CD47 is associated with microglial phagocytosis defects and autism-like behaviors in 16p11.2 deletion mice AI翻译
  作者：Ju, Jun; Pan, Yifan; Yang, Xinyi; Li, Xuanyi; Chen, Jinghong; Wu, Shiyu; Hou, Sheng-Tao; Shin, Hee-Sup
  作者单位：Southern University of Science & Technology
  摘要：Various pathological characteristics of autism spectrum disorder (ASD) stem from abnormalities in brain resident immune cells, specifically microglia, to prune unnecessary synapses or neural connections during early development. Animal models of ASD exhibit an abundance of synapses in different brain regions, which is strongly linked to the appearance of ASD behaviors. Overexpression of CD47 on neurons acts as a don't eat me signal, safeguarding synapses from inappropriate pruning by microglia...
• Protein Phosphatase 1 Regulatory Subunit 3C integrates cholesterol metabolism and isocitrate dehydrogenase in chondrocytes and neoplasia AI翻译
  作者：Nakagawa, Makoto; Shimada, Eijiro; Guardino, Nicholas; Miyamoto, Ryo; Puviindran, Vijitha; Peairs, Emily; Matarangas, Ariana; Ishikawa, Koji; Nguyen, Tuyet; Browne, Makenna; Marius, Choiselle; Wallace, Asjah; Hirata, Makoto; Nadesan, Puviindran; Alman, Benjamin A.
  作者单位：Duke University; Kyushu University; Duke University; National Cancer Center - Japan
  摘要：Enchondromas are common bone tumors composed of chondrocytes originating from growth plate cells which can progress to malignant chondrosarcoma. Mutations in the genes encoding isocitrate dehydrogenase (IDH1 and IDH2) are identified in a large proportion of these tumors. IDH enzymes convert isocitrate to alpha-ketoglutarate (Or-KG), an essential component of the citric acid cycle. While mutant IDH enzymes produce 2-hydroxyglutarate, which has epigenetic effects important in tumor initiation, c...
• Tearing down the house of mosquito- transmitted viruses AI翻译
  作者：Pandey, Shanti; Gack, Michaela U.
  作者单位：Cleveland Clinic Foundation
• NAL1 forms a molecular cage to regulate FZP phase separation AI翻译
  作者：Huang, Ling-Yun; Wang, Ting-Ting; Shi, Peng-Tao; Song, Ze-Yu; Chen, Wei-Fei; Liu, Na-Nv; Ai, Xia; Li, Hai-Hong; Hou, Xi-Miao; Wang, Li-Bing; Chen, Kun-Ming; Rety, Stephane; Xi, Xu-Guang
  作者单位：Northwest A&F University - China; Northwest A&F University - China; Northwest A&F University - China; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); CHU Lyon; Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; Universite Jean Monnet; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS)
  摘要：NARROWLEAF 1 (NAL1), originally identified for its role in shaping leaf morphology, plant architecture, and various agronomic traits in rice, has remained enigmatic in terms of the molecular mechanisms governing its multifaceted functions. In this study, we present a comprehensive structural analysis of NAL1 proteins, shedding light on how NAL1 regulates the phase separation of its physiological substrate, FRIZZY PANICLE (FZP), a transcription factor. We determined that NAL1 assembles as a hex...