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作者：Horne, Christopher R.; Dite, Toby A.; Young, Samuel N.; Mather, Lucy J.; Dagley, Laura F.; Johnson, Jared L.; Yaron-Barir, Tomer M.; Huntsman, Emily M.; Daly, Leonard A.; Byrne, Dominic P.; Cadell, Antonia L.; Ng, Boaz H.; Yousef, Jumana; Multari, Dylan H.; Shen, Lianju; Mcaloon, Luke M.; Manning, Gerard; Febbraio, Mark A.; Means, Anthony R.; Cantley, Lewis C.; Tanzer, Maria C.; Croucher, David R.; Eyers, Claire E.; Eyers, Patrick A.; Scott, John W.; Murphy, James M.
作者单位：Walter & Eliza Hall Institute; University of Melbourne; Monash University; Cornell University; Weill Cornell Medicine; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard Medical School; Cornell University; Weill Cornell Medicine; Columbia University; University of Liverpool; University of Liverpool; Garvan Institute of Medical Research; Australian Catholic University; St. Vincent's Institute of Medical Research; Baylor College of Medicine; University of New South Wales Sydney; Florey Institute of Neuroscience & Mental Health
摘要：Protein Serine Kinase H1 (PSKH1) was recently identified as a crucial factor in kidney development and is overexpressed in prostate, lung, and kidney cancers. However, little is known about PSKH1 regulatory mechanisms, leading to its classification as a dark kinase. Here, we used biochemistry and mass spectrometry to define PSKH1's consensus substrate motif, protein interactors, and how interactors, including Ca2+ sensor proteins, promote or suppress activity. Intriguingly, despite the absence...
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作者：Jiang, Tiantian; Lee, Jin Woo; Collins, Jennifer E.; Schaefer, Samuel; Chen, Daisy; Nardella, Flore; Wendt, Karen; Peramuna, Thilini G.; Paes, Raphaella; Mclellan, James L.; Bhasin, Jasveen; Durst, Gregory L.; Hanson, Kirsten K.; Chakrabarti, Debopam; Cichewicz, Robert H.; Winzeler, Elizabeth A.
作者单位：University of California System; University of California San Diego; Duksung Women's University; State University System of Florida; University of Central Florida; University of Michigan System; University of Michigan; University of Texas System; University of Texas at San Antonio; University of California System; University of California San Diego
摘要：Herein we report the finding and structure determination of a natural product based on the methyldeoxaphomin scaffold family from the fungus Trichocladium asperum that shows promising antiplasmodial activity and selectivity against host cells. In vitro evolution and whole genome analysis in Plasmodium falciparum with shows that parasite resistance to methyldeoxaphomins is strongly associated with mutations in PfActin1 (PF3D7_1246200), a critically essential ATPase needed for all stages of para...
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作者：Qiao, Wenjie; Xie, Xuping; Shi, Pei-Yong; Ooi, Yaw Shin; Carette, Jan E.
作者单位：Stanford University; University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; National University of Singapore; Agency for Science Technology & Research (A*STAR); A*STAR Infectious Diseases Labs (A*STAR IDL)
摘要：Mosquito- borne flaviviruses, such as dengue virus (DENV), Zika virus (ZIKV), West Nile virus, and yellow fever virus, pose significant public health threats globally. Extensive efforts have led to the development of promising highly active compounds against DENV targeting viral non- structural protein 4B (NS4B) protein. However, due to the cocirculation of flaviviruses and to prepare for emerging flaviviruses, there is a need for more broadly acting antivirals. Host- directed therapy where on...
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作者：Yao, Ze-Cheng; Chai, Jing; Tang, Tang; Ding, Liang; Jiang, Zhe; Fu, Jiaju; Chang, Xiaoxia; Xu, Bingjun; Zhang, Liang; Hu, Jin-Song; Wan, Li-Jun
作者单位：Chinese Academy of Sciences; Institute of Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Tsinghua University; Peking University
摘要：Electrocatalytic reduction (ECR) of furfural represents a sustainable route for biomass product distribution and industrial- incompatible production rates, mainly caused by the intricate mechanism-performance relationship. Here, we manipulate hydrogenation pathways on Cu by introducing ceria as an auxiliary component, which enables the mechanism switching from proton- coupled electron transfer to electrochemical hydrogen- atom transfer (HAT) and thus high- speed furfural- to- furfuryl alcohol ...
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作者：Brennecke, Benjamin; Civili, Beatrice; Sabale, Pramod M.; Barluenga, Sofia; Meyer, Benjamin; Winssinger, Nicolas
作者单位：University of Geneva; University of Geneva
摘要：Affinity proteins based on a three-helix bundle (affibodies, alphabodies, and computationally de novo designed ones) have been shown to be a general platform to discover binders with properties reminiscent of antibodies, combining high target specificity with affinities reaching well below the nanomolar. Herein, we report a strategy, coined self-assembled proteomimetic (SAP), to mimic such three-helix bundle architecture with a hybridization-enforced two-helix coiled coil that is obtained by t...
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作者：Wang, Zhihua; Cheng, Puxin; Han, Wenqing; Shi, Rongchao; Xu, Jian; Zheng, Yongshen; Xu, Jialiang; Bu, Xian-He
作者单位：Nankai University; Sinopec
摘要：Adaptive crystals have attracted significant attention from solid- state chemists and crystal engineers for their promising applications in memories, capacitors, sensors, and actuators. Among them, thermosalient crystals are particularly favored thanks to their efficient energy conversions and rapid responses. However, the mechanisms for the mechanical responses of thermosalient crystals remain largely unclear. Herein we demonstrate that thermosalient effects of molecular crystals could be dri...
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作者：Xu, Liang; Zhao, Xiao Hong; Zhang, Yuan Yuan; Zhang, Meng Yao; Zhang, Long Yue; Ye, Kai Hong; Teng, Liu; Han, Man Man; Yue, Yi Meng; Yang, Jiezhen; Ogle, Rachel; Netherton, Jacob; Tang, Deng; Lan, Siqi; Baker, Mark; Ye, Yan; Liu, Tao; Wang, Yu Fang; Zhang, Xu Dong; Fan, Tianli; Jin, Lei
作者单位：University of Newcastle; Zhengzhou University; Fudan University; Sichuan University; Anhui Medical University; University of New South Wales Sydney; Children's Cancer Institute; Children's Medical Research Institute - Australia; Zhengzhou University; University of Newcastle
摘要：The introns of the gene encoding the long noncoding RNA (lncRNA) GAS5 host up to 10 C/D box small nucleolar RNAs (snoRNAs). However, whether there is a regulatory and functional relationship between these snoRNAs and GAS5 is unknown. Here, we show that the expression of SNORD80, but not the other snoRNAs, parallels GAS5 expression and is regulated alongside GAS5 in response to cellular stress. The 2 '- O- methylation at the A496 site, located within a segment of GAS5 complementing the conserve...
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作者：Zhu, Haofang; Kong, Bin; Che, Junyi; Zhao, Yuanjin; Sun, Lingyun
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作者：Baekgaard, Martin; Nielsen, Soren Albeck; Rosholm, Michael; Svarer, Michael
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作者：Creel, Scott; Redcliffe, James; Goodheart, Ben; Merkle, Johnathan Reyes de; Mwape, Henry; Matsushima, Stephanie; Dart, Chase; Banda, Kachama; Mayani, Bridget; Njobvu, Johane; Kabungo, Reuben; Mungolo, Michelo; Kabwe, Ruth; Kaseketi, Emmanuel; Donald, Will; Kaluka, Adrian; Chifunte, Clive; Maimbo, Howard; Plankenhorn, Luzy; Christianson, David; Becker, Matthew S.; Wilson, Rory P.
作者单位：Montana State University System; Montana State University Bozeman; Swansea University; University of Wyoming
摘要：Large herbivores are in decline in much of the world, including sub- Saharan Africa, and true apex carnivores like the lion (Panthera leo) decline in parallel with their prey. As a consequence, competitively subordinate carnivores like the African wild dog (Lycaon pictus) are simultaneously experiencing a costly reduction in resources and a beneficial reduction in dominant competitors. The net effect is not intuitively obvious, but wild dogs' density, survival, and reproduction are all low in ...
