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作者：Kliuchnikov, Evgenii; Marx, Kenneth A.; Barsegov, Valeri; Mogilner, Alex
作者单位：University of Massachusetts System; University of Massachusetts Lowell; New York University; New York University
摘要：Accurate chromosome segregation in mitosis depends on proper connections of sister chromatids, through microtubules, to the opposite poles of the early mitotic spindle. Transiently, many inaccurate connections are formed and rapidly corrected throughout the mitotic stages, but a small number of merotelic connections, in which a chromatid is connected to both spindle poles, remain lagging at the spindle's equator in anaphase. Most of the lagging chromatids are eventually moved to one or the oth...
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作者：Monteagudo-Cascales, Elizabet; Gavira, Jose A.; Xing, Jiawei; Velando, Felix; Matilla, Miguel A.; Zhulin, Igor B.; Krell, Tino
作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Experimental del Zaidin (EEZ); Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto Andaluz de Ciencias de la Tierra (IACT); University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; Cold Spring Harbor Laboratory
摘要：Bacterial receptors feed into multiple signal transduction pathways that regulate a variety of cellular processes including gene expression, second messenger levels, and motility. Receptors are typically activated by signal binding to ligand- binding domains (LBDs). Cache domains are omnipresent LBDs found in bacteria, archaea, and eukar-yotes, including humans. They form the predominant family of extracytosolic bacterial LBDs and were identified in all major receptor types. Cache domains are ...
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作者：Shiffrin, Richard M.; Trueblood, Jennifer S.; Kellen, David; Vandekerckhove, Joachim
作者单位：Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Syracuse University; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine
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作者：Lusk, Bradley G.; Morgan, Sheba; Mulvaney, Shawn P.; Blue, Brandon; Lagasse, Sam W.; Cress, Cory D.; Bjerg, Jesper T.; Lee, Woo K.; Eddie, Brian J.; Robinson, Jeremy T.
作者单位：United States Department of Defense; United States Navy; United States Naval Research Laboratory; United States Department of Defense; United States Navy; United States Naval Research Laboratory; United States Department of Defense; United States Navy; United States Naval Research Laboratory; United States Department of Defense; United States Navy; United States Naval Research Laboratory; United States Department of Defense; United States Navy; United States Naval Research Laboratory; United States Department of Defense; United States Navy; United States Naval Research Laboratory; Aarhus University; United States Department of Defense; United States Navy; United States Naval Research Laboratory
摘要：This study presents the direct measurement of proton transport along filamentous Desulfobulbaceae, or cable bacteria. Cable bacteria are filamentous multicellular microorganisms that have garnered much interest due to their ability to serve as electrical conduits, transferring electrons over several millimeters. Our results indicate that cable bacteria can also function as protonic conduits because they contain proton wires that transport protons at distances >100 mu m. We find that protonic c...
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作者：Hu, Zhengqiang; Zhang, Fengling; Wu, Feng; Li, Li; Chen, Renjie
作者单位：Beijing Institute of Technology; Beijing Institute of Technology; Beijing Institute of Technology
摘要：Lithium- ion batteries (LIBs) have become advanced energy storage technologies; however, specific capacity remains limited by the active materials in cathodes. Here, we report Li-LiNO3 batteries (LNBs) where LiNO3 in electrolyte serves as both active materials and ion conductor at room temperature. LNBs operate on a highly reversible redox between NO3 - and NO2-, which results in an impressive areal capacity of 19 mAh cm-2 at a plateau voltage of 1.75 V. Furthermore, the pouch cell exhibits st...
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作者：van de Water, Jeroen A. J. M.; Bagci-Onder, Tugba; Agarwal, Aayush S.; Wakimoto, Hiroaki; Roovers, Rob C.; Zhu, Yanni; Kasmieh, Randa; Bhere, Deepak; Henegouwen, Paul M. P. Van Bergen en; Shah, Khalid
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作者：Zhang, Zhuoyu; Yao, Jingyu; Huo, Jingxiao; Wang, Ruolin; Duan, Xueting; Chen, Yang; Xu, Huadong; Wang, Changhe; Chai, Zuying; Huang, Rong
作者单位：Xi'an Jiaotong University; Tongji University; Southwest Medical University; Johns Hopkins University
摘要：Neurotransmitters and neuromodulators can be released via either action potential (AP)-evoked transient or AP- independent continuous neurotransmission. The elevated AP- evoked neurotransmission in the primary sensory neurons plays crucial roles in hyperalgesia. However, whether and how the AP- independent continuous neurotransmission contributes to hyperalgesia remains largely unknown. Here, we show that primary sensory dorsal root ganglion (DRG) neurons exhibit frequent spontaneous microdoma...
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作者：Dome, Patrick A.; Jeong, Pyeonghwa; Nam, Gibeom; Jang, Hongjun; Rivera, Angela; Averette, Anna Floyd; Park, Eunchong; Liao, Tzu-Chieh; Ciofani, Maria; Wu, Jianli; Chi, Jen-Tsan Ashley; Venters, Ronald A.; Park, Hyun-Ju; Steinbach, William J.; Juvvadi, Praveen R.; Heitman, Joseph; Hong, Jiyong
作者单位：Duke University; Sungkyunkwan University (SKKU); Duke University; Duke University; Duke University; Duke University; Duke University; University of Arkansas System; University of Arkansas Medical Sciences
摘要：Invasive fungal infections are a leading cause of death worldwide. Translating molecular insights into clinical benefits is challenging because fungal pathogens and their hosts share similar eukaryotic physiology. Consequently, current antifungal treatments have limited efficacy, may be poorly fungicidal in the host, can exhibit toxicity, and are increasingly compromised by emerging resistance. We have established that the phosphatase calcineurin (CaN) is required for invasive fungal disease a...
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作者：Sokolowski, Thomas R.; Gregor, Thomas; Bialek, William; Tkacik, Gasper
作者单位：Institute of Science & Technology - Austria; Princeton University; Princeton University; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Rockefeller University
摘要：Many biological systems operate near the physical limits to their performance, suggesting that aspects of their behavior and underlying mechanisms could be derived from optimization principles. However, such principles have often been applied only in simplified models. Here, we explore a detailed mechanistic model of the gap gene network in the Drosophila embryo, optimizing its 50+ parameters to maximize the information that gene expression levels provide about nuclear positions. This optimiza...
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作者：Vohryzek, Jakub; Sanz-Perl, Yonatan; Kringelbach, Morten L.; Deco, Gustavo
作者单位：Pompeu Fabra University; University of Barcelona; University of Oxford; University of Oxford; Aarhus University; ICREA
摘要：A fundamental topological principle is that the container always shapes the content. In neuroscience, this translates into how the brain anatomy shapes brain dynamics. From neuroanatomy, the topology of the mammalian brain can be approximated by local connectivity, accurately described by an exponential distance rule (EDR). The compact, folded geometry of the cortex is shaped by this local connectivity, and the geometric harmonic modes can reconstruct much of the functional dynamics. However, ...
