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作者：Wang, Yang; Li, Xing; Liu, Chang; Wang, Yunqi; You, Chunyu; Zhu, Hong; Zheng, Zhi; Zhang, Ziyu; Jiang, Guobang; Dong, Xiang; Cai, Tianjun; Tian, Ziao; Di, Zengfeng; Huang, Gaoshan; Chen, Xiangzhong; Song, Enuring; Cui, Jizhai; Mei, Yongfeng
作者单位：Fudan University; Fudan University; Fudan University; Chinese Academy of Sciences; Shanghai Institute of Microsystem & Information Technology, CAS; Fudan University
摘要：Microscopic robots exhibit efficient locomotion in liquids by leveraging fluid dynamics and chemical reactions to generate force asymmetry, thereby enabling critical applications in photonics and biomedicine. However, achieving controllable locomotion of such robots on terrestrial surfaces remains challenging because fluctuating adhesion on nonideal surfaces disrupts the necessary asymmetry for propulsion. Here, we present a microscopic robot composed of three-dimensional nanomembranes, which ...
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作者：Yang, Siyan; Ji, Bingqiang; Feng, Yawei; Jin, Yuankai; Xu, Wanghuai; Lu, Jingyi; Qin, Xuezhi; Zhang, Huanhuan; Li, Mingyu; Xu, Zhenyu; Liu, Xiaonan; Xu, Luqing; Wang, Dehui; Wen, Rongfu; Wang, Zhenying; Wang, Steven; Ma, Xuehu; Wang, Zuankai
作者单位：Hong Kong Polytechnic University; City University of Hong Kong; Beihang University; University of Electronic Science & Technology of China; Dalian University of Technology; State Key Laboratory Surfactant Fine Chemistry; Kyushu University
摘要：The freezing of droplets on surfaces is closely relevant with various industrial processes such as aviation, navigation, and transportation. Previous studies mainly focus on physiochemically heterogeneous but electrically homogeneous surfaces, on which the presence of vapor pressure gradient between droplets is the predominant mechanism for interdroplet freezing bridging, propagation, and eventual frosting across the entire surface. An interesting yet unanswered question is whether electrostat...
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作者：Maciag, Joseph J.; Slone, Conner E.; Alnajjar, Hala F.; Rich, Maria F.; Guion, Bryce; Ifergan, Igal; Blobel, Carl P.; Seegar, Tom C. M.
作者单位：University System of Ohio; University of Cincinnati; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine
摘要：The endopeptidase activity of ADAM (a disintegrin and metalloproteinase)-17, the primary processor of several EGFR ligands and tumor necrosis factor-alpha (TNF-alpha), is essential for proper embryonic development and immune regulation. Dysregulated ADAM17 activity is prevalent in a wide array of human diseases, including cancer, chronic inflammation, and SARS-CoV-2 viral progression. Initially translated as inactive zymogen, ADAM17 maturation and enzymatic function are tightly regulated by it...
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作者：Park, Jun Bae; Lee, Gwanwoo; Han, Yu - Yeon; Kim, Dongwook; Heo, Kyoo; Kim, Jeesoo; Park, Juhee; Yun, Hyosuk; Lee, Chul Won; Cho, Hyun- Soo; Kim, Jong- Seo; Steinegger, Martin; Seok, Yeong- Jae; Roh, Soung- Hun
作者单位：Seoul National University (SNU); Seoul National University (SNU); Seoul National University (SNU); Seoul National University (SNU); Seoul National University (SNU); Institute for Basic Science - Korea (IBS); Chonnam National University; Yonsei University
摘要：GCN5- related N- acetyltransferases (GNATs) are essential for regulating bacterial metabolism by acetylating specific target proteins. Despite their importance in bacterial physiology, the mechanisms behind their enzymatic and regulatory functions remain poorly understood. In this study, we investigated the structures of Escherichia coli protein alytic mechanism, and allosteric regulation. PatZ functions as a homotetramer, with each subunit comprising a catalytic and a regulatory domain. Our r...
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作者：Avila, Bryant; Augusto, Pedro; Hashemi, Alireza; Phillips, David; Gili, Tommaso; Zimmer, Manuel; Makse, Hernan A.
作者单位：City University of New York (CUNY) System; City College of New York (CUNY); City University of New York (CUNY) System; City College of New York (CUNY); University of Vienna; Vienna Biocenter (VBC); University of Vienna; Vienna Biocenter (VBC); Medical University of Vienna; Medical University of Vienna; City University of New York (CUNY) System; Memorial Sloan Kettering Cancer Center; University of New Mexico; City University of New York (CUNY) System
摘要：Understanding the dynamical behavior of complex systems from their underlying network architectures is a long-standing question in complexity theory. Therefore, many metrics have been devised to extract network features like motifs, centrality, and modularity measures. It has previously been proposed that network symmetries are of particular importance since they are expected to underlie the synchronization of a system's units, which is ubiquitously observed in nervous system activity patterns...
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作者：Noack, Christopher; Jenderny, Sebastian; Giez, Christoph; Merza, Ornina; Hofacker, Lisa-Marie; Repnik, Urska; Bramkamp, Marc; Ochs, Karlheinz; Wittlieb, Joerg; Bosch, Thomas C. G.
作者单位：University of Kiel; Ruhr University Bochum; Francis Crick Institute; University of Kiel; University of Kiel; University of Kiel
摘要：Understanding how neural populations emerge to give rise to behavior is a major goal in neuroscience. Here, we explore the self-assembly of neural circuits in Hydra, an organism with a simple nervous system but no centralized information processing, to enhance the understanding of nervous system evolution. We define self-assembly as spontaneous organization of neurons into functional circuits without requiring a prespecified structural template. In this context, the N4 neuronal circuit, which ...
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作者：Pearson, Talima; Furstenau, Tara; Wood, Colin; Rigas, Vanessa; Drake, Kylie; Sahl, Jason; Maltinsky, Sara; Currie, Bart J.; Mayo, Mark; Hall, Carina; Keim, Paul; Fofanov, Viacheslav
作者单位：Northern Arizona University; Northern Arizona University; Charles Darwin University; Menzies School of Health Research; Royal Darwin Hospital; Royal Darwin Hospital
摘要：Genomic diversity in pathogen populations is foundational for evolution and adaptation. Understanding population- level diversity is also essential for tracking sources and revealing detailed pathways of transmission and spread. For bacteria, culturing, isolating, and sequencing the large number of individual colonies required to adequately sample diversity can be prohibitively time- consuming and expensive. While sequencing directly from a mixed population will show variants among reads, they...
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作者：Han, Jie; Wang, Shuideng; Zheng, Zhiqiang; Chen, Donglei; Zhang, Wenqi; Qu, Zhi; Cheng, Mingxing; Yao, Yiqing; Sitti, Metin; Dong, Lixin
作者单位：Xi'an Jiaotong University; Max Planck Society; City University of Hong Kong; Koc University
摘要：Soft magnetic miniature devices are crucial for applications in minimally invasive medicine, soft electronics, and robotics. While substantial progress has been made, current magnetic programming techniques are inherently tied to template-based and sequential fabrication processes. These processes limit scalability, precision, and programmability. Here, we present a template-free, integrative strategy that leverages interlayer stress-induced 3D shape morphing in xerogel-PDMS bilayer materials ...
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作者：Sharma, Babita; Aswin, Keerthic; Jain, Tanya; Nasreen, Ayesha; Aggarwal, Ayush; Subramaniam, Yogaspoorthi J.; Rengaraju, Jeyashri; Agrawal, Srashti Jyoti; Bhatt, Mayank; Paul, Bhashkar; Chandrasekaran, Koushika; Yadav, Aanchal; Soni, Jyoti; Ujjainiya, Rajat; Akhter, Md Quasid; Pandey, Rajesh; Suresh, Shruthy; Sampathkumar, Srinivasa -- Gopalan; Natarajan, Vivek T.
作者单位：Council of Scientific & Industrial Research (CSIR) - India; CSIR - Institute of Genomics & Integrative Biology (IGIB); Academy of Scientific & Innovative Research (AcSIR); Department of Biotechnology (DBT) India; National Institute of Immunology (NII)
摘要：Melanocyte development involves key pathways that are often recapitulated during melanoma initiation, highlighting the importance of understanding these regulatory processes. Our study identifies mgat4b, a glycosyl transferase involved in selective N-glycan branching enriched in pigment progenitors, as a regulator of directional cell migration and establishment of melanocyte stem cell (McSC) pool during early development. Single cell RNA (scRNA) sequencing analysis in zebrafish upon targeted d...
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作者：Xing, Yikun; Santos, Haroldo J. Hernandez; Qiu, Ling; Ritter, Samantha R.; Zulk, Jacob J.; Lahowetz, Rachel; Patras, Kathryn A.; Terwilliger, Austen L.; Maresso, Anthony W.
作者单位：Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine
摘要：Bacteriophages, or phages, are viruses that target and infect bacteria. Due to a worldwide rise in antimicrobial resistance (AMR), phages have been proposed as a promising alternative to antibiotics for the treatment of resistant bacterial infections. Up to this point in history, phage use in preclinical animal studies, clinical trials, and emergency- use compassionate care cases has centered around the original observation from 1915 showing phage as lytic agent, and thus a treatment that kill...
