2025

最新文章

• Translation elongation defects activate the Caenorhabditis elegans ZIP-2 bZIP transcription factor-mediated toxin defense AI翻译
  作者：Kniazeva, Marina; Ruvkun, Gary
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School
  摘要：The Caenorhabditis elegans bZIP transcription factor ZIP- 2 is activated by toxins or mutations that inhibit translational elongation. The zip- 2 DNA- binding protein is encoded in a downstream main open reading frame (mORF), but under normal translation elongation conditions only an upstream overlapping oORF- 1 frameshifted from mORF is translated. Mutations or toxins that slow translational elongation, but not inhibitors of translational initiation or termination, activate ZIP- 2. An mORF in...
• CO2 potentiates echinocandin efficacy during invasive candidiasis therapy via dephosphorylation of Hsp90 by Ptc2 in condensates AI翻译
  作者：Zhang, Mao; Zhao, Youzhi; Cui, Hao; Huang, Wenqiang; Xiong, Kang; Yang, Shan; Duan, Yuanyuan; He, Yong; Yang, Lianjuan; Su, Chang; Lu, Yang
  作者单位：Anhui Medical University; Anhui Medical University; Wuhan University; Anhui Medical University; Wuhan University; Tongji University
  摘要：Carbon dioxide is a signaling cue critical for fungal pathogenesis. Ptc2, a type 2C phosphoproteomic and biochemical assays, we identified Hsp90 as a direct target of Ptc2 at host CO2 concentrations and Ssb1 as a Ptc2 target protein regardless of CO2 levels in Candida albicans, the most prevalent human fungal pathogen. Ptc2 forms reversible condensates at elevated CO2, which enables the recruitment of Hsp90, but not Ssb1, to condensates, allowing efficient dephosphorylation. This process confe...
• Metabolic activity controls the emergence of coherent flows in microbial suspensions AI翻译
  作者：Fragkopoulos, Alexandros A.; Boehme, Florian; Drewes, Nicole; Baeumchen, Oliver
  作者单位：University of Bayreuth; Max Planck Society
  摘要：Photosynthetic microbes have evolved and successfully adapted to the ever-changing environmental conditions in complex microhabitats throughout almost all ecosystems on Earth. In the absence of light, they can sustain their biological functionalities through aerobic respiration, and even in anoxic conditions through anaerobic metabolic activity. For a suspension of photosynthetic microbes in an anaerobic environment, individual cellular motility is directly controlled by its photosynthetic act...
• Cortical reorganization following dorsal spinal injuries in newborn monkeys reveals a critical period in the development of the somatosensory cortex AI翻译
  作者：Jain, Neeraj; Qi, Hui- Xin; Raman, Arun; Lyon, David; Kaas, Jon H.
  作者单位：Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Jodhpur; Vanderbilt University; Department of Biotechnology (DBT) India; National Brain Research Centre (NBRC); University of California System; University of California Irvine
  摘要：Lesions of the dorsal columns of the spinal cord in adult macaque monkeys lead to the loss of hand inputs and large- scale expansion of the face inputs in the hand region of the somatosensory cortex. Inputs from alternate spinal pathways do not reactivate the deafferented regions of area 3b. Here, we determined how transections of the dorsal columns done within a few days after birth affect the developing somatosensory cortex. Dorsal columns were transected between the 3rd and 12th postnatal d...
• Multiorifice acoustic microrobot for boundary- free multimodal 3D swimming AI翻译
  作者：Mahkam, Nima; Ugurlu, Musab C.; Kalva, Sandeep Kumar; Aghakhani, Amirreza; Razansky, Daniel; Sitti, Metin
  作者单位：Max Planck Society; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Geneva; University of Zurich; University of Stuttgart; Koc University; Koc University; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Bombay
  摘要：The emerging new generation of small- scaled acoustic microrobots is poised to expedite the adoption of microrobotics in biomedical research. Recent designs of these microrobots have enabled intricate bioinspired motions, paving the way for their real- world applications. We present a multiorifice design of air- filled spherical microrobots that convert acoustic wave energy to efficient propulsion through a resonant encapsulated microbubble. These microrobots can swim boundary- free in three- ...
• Band asymmetry-driven nonreciprocal electronic transport in a helimagnetic semimetal α-EuP3 AI翻译
  作者：Mayo, Alex Hiro; Deaconu, Darius - Alexandru; Masuda, Hidetoshi; Nii, Yoichi; Takahashi, Hidefumi; Belosludov, Rodion Vladimirovich; Ishiwata, Shintaro; Bahramy, Mohammad Saeed; Onose, Yoshinori
  作者单位：Tohoku University; University of Manchester; University of Osaka
  摘要：Chiral magnetic textures give rise to unconventional magnetotransport phenomena such as the topological Hall effect and nonreciprocal electronic transport. While the correspondence between topology or symmetry of chiral magnetic structures and such transport phenomena has been well established, a microscopic understanding based on the spin- dependent band structure in momentum space remains elusive. Here, we demonstrate how a chiral magnetic superstructure introduces an asymmetry in the electr...
• Falling racial inequality and rising educational inequality in US prison admissions for drug, violent, and property crimes AI翻译
  作者：Muller, Christopher; Roehrkasse, Alexander F.
  作者单位：Harvard University; Butler University; Cornell University
  摘要：Using administrative and survey data, we show that there has been a sea change in the contours of American imprisonment. At the end of the twentieth century, inequality in the prison admission rates of Black and White Americans was comparable to inequality in the prison admission rates of people with and without a college education. However, educational inequality is now much greater than racial inequality in prison admissions for all major crime types. Violent offenses have replaced drug offe...
• A solution to the pervasive problem of response bias in self-reports AI翻译
  作者：Grimmond, Jess; Brown, Scott D.; Hawkins, Guy E.
  作者单位：University of Newcastle
  摘要：Self-reports are used ubiquitously to probe people's thoughts, feelings, and behaviors and inform medical decisions, enterprise operations, and government policy and legislation. Despite their pervasive use, self-report measures such as Likert scales have a profound problem: Standard analytic approaches do not control for the confounding effects of idiosyncratic response biases. Here, we present a model-based solution to this problem. Our model disentangles response bias from latent constructs...
• Burrow collapse is not the only explanation for rapid, noncatastrophic preservation of 3D dinosaurs AI翻译
  作者：Wetherell, Meaghan M. Emery-
  作者单位：University of Arizona
• An evolutionarily conserved cation channel tunes the sensitivity of gustatory neurons to ephaptic inhibition in Drosophila AI翻译
  作者：Lee, Minhyuk; Kim, Seon Yeong; Park, Taeim; Yoon, Sung-Eun; Kim, Young-Joon; Joo, Kyeung Min; Kwon, Jae Young; Kim, Kyuhyung; Kang, Kyeongjin
  作者单位：Korea Brain Research Institute (KBRI); Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan University (SKKU); Daegu Gyeongbuk Institute of Science & Technology (DGIST); Gwangju Institute of Science & Technology (GIST)
  摘要：In ephaptic coupling, physically adjacent neurons influence one another's activity via the electric fields they generate. To date, the molecular mechanisms that mediate and modulate ephaptic coupling's effects remain poorly understood. Here, we show that the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel lateralizes the potentially mutual ephaptic inhibition between Drosophila gustatory receptor neurons (GRNs). While sweet-sensing GRNs (sGRNs) engage in ephaptic suppression ...