2025

最新文章

• Modulation of human dorsal root ganglion neuron firing by the Nav1.8 inhibitor suzetrigine AI翻译
  作者：Stewart, Robert G.; Osorno, Tomas; Fujita, Akie; Jo, Sooyeon; Ferraiuolo, Alyssa; Carlin, Kevin; Bean, Bruce P.
  作者单位：Harvard University; Harvard Medical School
  摘要：Nav1.8 voltage-gated sodium channels are strongly expressed in human primary pain-sensing neurons (nociceptors) and a selective Nav1.8 inhibitor VX-548 (suzetrigine) has shown efficacy for treating acute pain in clinical trials. Nociceptors also express other sodium channels, notably Nav1.7, raising the question of how effectively excitability of the neurons is reduced by inhibition of Nav1.8 channels alone. We used VX-548 to explore this question, recording from dissociated human dorsal root ...
• The IL-18 receptor is expressed on murine small- intestinal enterochromaffin cells and executes a recovery program upon injury AI翻译
  作者：Winsor, Nathaniel J.; Tsang, Derek K.; Ranger, Adrienne; Singh, Ojas; Goyal, Shawn; Philpott, Dana J.; Girardin, Stephen E.
  作者单位：University of Toronto; University of Toronto
  摘要：Upon injury, epithelial-derived IL-18 is released and induces an inflammatory response in underlying IL18R1+ lamina propria cells. Notably, Il18r1 is also predicted to be expressed and functional in intestinal epithelial cells (IECs), since epithelial IL18R1 deficiency contributes to worsened outcomes upon inflammatory challenge. However, the nature of Il18r1+ IECs, and their subsequent role in epithelial-intrinsic IL-18 signaling is poorly characterized. Here, we show that, in the murine smal...
• A founding father of neuroscience: Floyd E. Bloom, 1936-2025 AI翻译
  作者：Aston-Jones, Gary; Foote, Stephen L.; Morrison, John H.
  作者单位：Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; University of California System; University of California Davis
  摘要：Floyd E. Bloom, M.D. was a prominent leader and spokesperson for the neuroscience and broader scientific communities; sadly, were focused on multidisciplinary characterizations of transmitter- specific neural pathways in the brain. An innovative neuroanatomist and neurophysiologist, he spearheaded the development of new techniques and multidisciplinary paradigms for demonstrating the functions of neurotransmitters at the circuit, cellular, and subcellular levels. His work was especially import...
• Mutant IDH1 cooperates with NPM1c or FLT3ITD to drive distinct myeloid diseases and molecular outcomes AI翻译
  作者：Sakamoto, Takashi; Leca, Julie; Zhang, Xin; Meydan, Cem; Foox, Jonathan; Ramachandran, Parameswaran; Hendrikse, Liam D.; Zhou, Wenjing; Berger, Thorsten; Fortin, Jerome; Chan, Steven M.; Chiang, Ming-Feng; Inoue, Satoshi; Li, Wanda Y.; Chu, Mandy F.; Duncan, Gordon S.; Wakeham, Andrew; Lemonnier, Francois; Tobin, Chantal; Mcwilliam, Ryan; Colonna, Isabelle; Bontoux, Christophe; Jafari, Soode Moghadas; Bowman, Robert L.; Nicolay, Brandon; Ronseaux, Sebastien; Narayanaswamy, Rohini; Levine, Ross L.; Melnick, Ari M.; Mason, Christopher E.; Minden, Mark D.; Mak, Tak W.
  作者单位：University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; Kyoto University; Universite Claude Bernard Lyon 1; UNICANCER; Centre Leon Berard; Institut National de la Sante et de la Recherche Medicale (Inserm); Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; McGill University; National Cancer Center - Japan; Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; CHU de Toulouse; Institut National de la Sante et de la Recherche Medicale (Inserm); Memorial Sloan Kettering Cancer Center; Agios Pharmaceuticals; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; University of Hong Kong
  摘要：In human acute myeloid leukemia (AML), mutations of isocitrate dehydrogenase-1 (IDH1) often co-occur with NPM1 mutations, and less frequently with FLT3 mutations. To investigate whether the effects of IDH1 mutation differ according to the specific co-occurring mutation, we generated two strains of double knock-in mutant mice. Idh1R132H combined with Npm1c induced overt AML, whereas Idh1R132H plus Flt3ITD resulted in Flt3ITD-driven myelo-or lymphoproliferation that was minimally affected by Idh...
• Loss of insulin signaling in microglia impairs cellular uptake of Aβ and neuroinflammatory response exacerbating AD- like neuropathology AI翻译
  作者：Chen, Wenqiang; Liu, Xiangyu; Munoz, Vitor Rosetto; Kahn, C. Ronald
  作者单位：Harvard University; Harvard University Medical Affiliates; Joslin Diabetes Center, Inc.; Harvard Medical School; Harvard University; Harvard Medical School; Steno Diabetes Center; Universidade Estadual de Campinas
  摘要：Insulin receptors are present on cells throughout the body, including the brain. Dysregulation of insulin signaling in neurons and astrocytes has been implicated in altered mood, cognition, and the pathogenesis of Alzheimer's disease (AD). To define the role of insulin signaling in microglia, the primary phagocytes in the brain critical for maintenance and damage repair, we created mice with an inducible microglia-specific insulin receptor knockout (MG-IRKO). RiboTag profiling of microglial mR...
• Distinct latitudinal patterns of molecular rates across vertebrates AI翻译
  作者：Cai, Tianlong; Wen, Zhixin; Jiang, Zhongguan; Zhen, Ying
  作者单位：Westlake Laboratory; Westlake University; Westlake University; Westlake University; Chinese Academy of Sciences; Institute of Zoology, CAS; Anhui University
  摘要：The latitudinal diversity gradient (LDG) is the most notable global biodiversity pattern, but its underlying mechanisms remain unresolved. The evolutionary speed hypothesis (ESH) posits that molecular rates play a crucial role in shaping the LDG, suggesting that higher temperatures accelerate molecular rates, thereby facilitating rapid speciation and accumulation of biodiversity in the tropics. However, whether ESH can explain the LDG across diverse taxonomic groups remains debated, and system...
• Amplification mechanism with interacting atomic gases AI翻译
  作者：Jiang, Min; Qin, Yushu; Wang, Yuanhong; Huang, Ying; Peng, Xinhua; Budker, Dmitry
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Hefei National Laboratory; Helmholtz Association; GSI Helmholtz-Center for Heavy Ion Research; Johannes Gutenberg University of Mainz; University of California System; University of California Berkeley
  摘要：The use of atoms, molecules, and free electrons in quantum amplifiers has greatly advanced precision measurements, paving the way for the development of extremely-low-noise quantum devices such as masers and lasers. Here, we investigate the signal amplification of interacting spins and observe the amplification of magnetic fields using mixtures of interacting alkali-metal and noble gases. In contrast to noninteracting systems used as amplifiers, we demonstrate that interactions resulting from ...
• A hierarchy of processing complexity and timescales for natural sounds in the human auditory cortex AI翻译
  作者：Rupp, Kyle M.; Hect, Jasmine L.; Harford, Emily E.; Holt, Lori L.; Ghuman, Avniel Singh; Abel, Taylor J.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Texas System; University of Texas Austin; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：Efficient behavior is supported by humans' ability to rapidly recognize acoustically distinct sounds as members of a common category. Within the auditory cortex, critical unanswered questions remain regarding the organization and dynamics of sound categorization. We performed intracerebral recordings during epilepsy surgery evaluation as 20 patient-participants listened to natural sounds. We then built encoding models to predict neural responses using sound representations extracted from diffe...
• Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis AI翻译
  作者：Sakuma, Ikki; Gaspar, Rafael C.; Nasiri, Ali R.; Dufour, Sylvie; Kahn, Mario; Zheng, Jie; Lamoia, Traci E.; Guerra, Mateus T.; Taki, Yuki; Kawashima, Yusuke; Yimlamai, Dean; Perelis, Mark; Vatner, Daniel F.; Petersen, Kitt Falk; Huttasch, Maximilian; Knebel, Birgit; Kahl, Sabine; Roden, Michael; Samuel, Varman T.; Tanaka, Tomoaki; Shulman, Gerald I.
  作者单位：Yale University; Chiba University; Yale University; Ionis Pharmaceuticals, Inc.; Leibniz Association; Deutsches Diabetes-Zentrum (DDZ); Heinrich Heine University Dusseldorf; German Center for Diabetes Research (DZD); Heinrich Heine University Dusseldorf; Leibniz Association; Deutsches Diabetes-Zentrum (DDZ); Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf Hospital; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Connecticut Healthcare System; Yale University; Howard Hughes Medical Institute
  摘要：Metabolic dysfunction-associated steatohepatitis (MASH) represents a progressive form of steatotic liver disease which increases the risk for fibrosis and advanced liver disease. The accumulation of discrete species of bioactive lipids has been postulated to activate signaling pathways that promote inflammation and fibrosis. However, the key pathogenic lipid species is a matter of debate. We explored candidates using various dietary, molecular, and genetic models. Mice fed a choline-deficient ...
• A responsive living material prepared by diffusion reveals extracellular enzyme activity of cyanobacteria AI翻译
  作者：Tang, Lisa; Soulier, Nathan T.; Wheeler, Rebecca; Pokorski, Jonathan K.; Golden, James W.; Golden, Susan S.; Bae, Jinhye
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Chung Ang University
  摘要：Stimuli-responsive engineered living materials (ELMs) can respond to environmental or biochemical cues and have broad utility in biological sensors and machines, but have traditionally been limited to biocompatible scaffolds. This is because they are typically made by mixing cells into a precursor solution before crosslinking. Here, we demonstrate a diffusion mechanism for incorporating cells of the cyanobacterium Synechococcus elongatus sp. PCC 7942 (S. elongatus) into nanoclay-poly-N-isoprop...