2025

最新文章

• Noncanonical action of circadian clock genes controls winter diapause entry via the NuA4/TIP60 complex in Harmonia axyridis AI翻译
  作者：Gao, Qiao; Dai, Yi-Fei; Zhao, Yu-Lian; Li, Xue; An, Hao-Min; King-Jones, Kirst; Wang, Jia-Lu; Wang, Xiao-Ping; Liu, Wen
  作者单位：Huazhong Agricultural University; University of Alberta
  摘要：To adapt to seasonal changes, many animals, particularly insects, enter a dormancy-like condition known as diapause, which is primarily accomplished by sensing photoperiodic signals. The circadian clock, which is driven by positive regulators Clock (CLK) and Cycle (CYC), and negative regulators Period and Timeless, is thought to mediate this response. However, it remains unclear whether diapause induction involves a canonical rhythmic mechanism or occurs independently of their traditional role...
• Autophagic stress activates distinct compensatory secretory pathways in neurons AI翻译
  作者：Palumbos, Sierra D.; Popolow, Jacob; Goldsmith, Juliet; Holzbaur, Erika L. F.
  作者单位：University of Pennsylvania
  摘要：Autophagic dysfunction is a hallmark of neurodegenerative disease, leaving neurons vulnerable to the accumulation of damaged organelles and aggregated proteins. However, the late onset of diseases suggests that compensatory quality control mechanisms may be engaged to delay these deleterious effects. Neurons expressing common familial Parkinson's disease-associated mutations in the leucine-rich repeat kinase 2 (LRRK2) exhibit defective autophagy. Here, we demonstrate that both primary murine n...
• BIK polymorphism and proteasome regulation unveil host risk factor for severe influenza AI翻译
  作者：Soni, Sourabh; Yildiz, Soner; Allen, Emma Kaitlynn; Petersen, Hans; Peeples, Mark; El Zahed, Sara; Rosas, Lorena; Anang, Vandana; Antonescu, Laura; Nho, Richard Seonghun; Mora, Ana Lucia; Horowitz, Jeffrey Craig; Rojas, Mauricio; Medina, Rafael Andres; Thomas, Paul Glyndwr; Garcia-Sastre, Adolfo; Tesfaigzi, Yohannes; Mebratu, Yohannes Afework
  作者单位：University System of Ohio; Ohio State University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; St Jude Children's Research Hospital; Lovelace Respiratory Research Institute; University System of Ohio; Ohio State University; Nationwide Childrens Hospital; Research Institute at Nationwide Children's Hospital; Center for Vaccines & Immunity; Emory University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital
  摘要：Influenza A viruses (IAVs) pose a significant public health threat, with host factors playing a crucial role in disease severity. We investigated the role of Bcl-2-interacting killer (BIK) in IAV infection using cellular and mouse models, and influenza-infected human cohort. In airway epithelial cells (AECs), BIK deficiency impaired viral replication, while BIK restoration enhanced it. Conversely, airway-specific BIK overexpression in mice increased viral load, inflammation, and mortality, whe...
• Electrochemically controlled switching of dyes for enhanced superresolution optical fluctuation imaging (EC-SOFI) AI翻译
  作者：Yang, Ying; Ma, Yuanqing; Tilley, Richard D.; Gooding, J. Justin
  作者单位：University of New South Wales Sydney; University of New South Wales Sydney; University of New South Wales Sydney; European Molecular Biology Laboratory (EMBL); University of New South Wales Sydney
  摘要：In superresolution optical fluctuation imaging (SOFI), molecules spaced closer than the diffraction limit can be separated through spatial and temporal correlation analysis of the fluorescence intensity fluctuations. The resolution and speed of SOFI imaging greatly depend on the characteristics of these fluorescence fluctuations. Fluorophores with stochastic and rapid fluorescence fluctuations are favorable for improving SOFI imaging resolution and speed, especially in high-order cumulant anal...
• Tendencies toward triadic closure: Field experimental evidence AI翻译
  作者：Mosleh, Mohsen; Eckles, Dean; Rand, David G.
  作者单位：University of Oxford; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
  摘要：Empirical social networks are characterized by a high degree of triadic closure (i.e., transitivity, clustering): network neighbors of the same individual are also likely to be directly connected. It is unknown to what degree this results from dispositions to form such ties (i.e., to close open triangles) per se versus other processes such as homophily and more opportunities for exposure. These mechanisms are difficult to disentangle in many settings. On social media, however, they can be deco...
• Human milk IgA promotes normal immune development by limiting Th17-inducing Erysipelatoclostridium ramosum in the infant gut AI翻译
  作者：Donald, Katherine; Serapio-Palacios, Antonio; Bozorgmehr, Tahereh; Ma, Mandi; Garcia, Ma Andrea Isabelle; Petersen, Charisse; Mandhane, Piushkumar; Subbarao, Padmaja; Moraes, Theo J.; Simons, Elinor; Turvey, Stuart; Azad, Meghan B.; Finlay, B. Brett
  作者单位：University of British Columbia; University of British Columbia; University of California System; University of California Davis; University of British Columbia; BC Children's Hospital; University of Alberta; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto; McMaster University; University of Manitoba; University of Manitoba; University of Manitoba; Children's Hospital Research Institute of Manitoba; University of Manitoba; University of British Columbia
  摘要：The gut microbiota is highly dynamic during the first year of life and plays a crucial role in immune development. Breastfeeding is known to support infant health, but the contributions of the numerous breastmilk components to gut microbiota and immune maturation remain unclear. Secretory IgA (SIgA), the most abundant antibody in human milk, is a key modulator of gut microbiota composition. We have shown previously that mouse milk SIgA protects against asthma by limiting segmented filamentous ...
• Structure-based discovery of positive allosteric modulators of the A1 adenosine receptor AI翻译
  作者：Nguyen, Anh T. N.; Panel, Nicolas; Vo, Duc Duy; Thai, Bui San; Chia, Ling Yeong; Lu, Cam Sinh; Hellyer, Shane D.; Langiu, Monica; Jorg, Manuela; Gregory, Karen J.; Kihlberg, Jan; White, Paul J.; Scammells, Peter J.; Christopoulos, Arthur; Carlsson, Jens; May, Lauren T.
  作者单位：Monash University; Uppsala University; Uppsala University; Monash University; Monash University
  摘要：Allosteric modulation of G protein-coupled receptors (GPCRs) is an exciting strategy for developing new therapeutic agents, and it has several advantages over more commonly used orthosteric drugs. Recently determined GPCR structures have revealed allosteric pockets facing the lipid bilayer, enabling rational drug design. Here, we develop a virtual screening strategy to discover ligands of extrahelical binding pockets and apply this approach to the adenosine A1 receptor (A1R). The A1R is a high...
• SARS-CoV-2 nucleocapsid protein directly prevents cGAS-DNA recognition through competitive binding AI翻译
  作者：Gutmann, Theresia; Kuster, David; Hyman, Anthony A.
  作者单位：Max Planck Society
  摘要：A hallmark of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is the delayed interferon response. Interferons are typically produced upon host recognition of pathogen-or damage-associated molecular patterns, such as nucleic acids. While the mechanisms by which SARS-CoV-2 evades host recognition of its RNA are well studied, how it evades immune responses to cytosolic DNA-leaked from mitochondria or nuclei during infection-remains poorly understood. Here, we demonstrate th...
• Light controls gene functions through alternative splicing in fungi AI翻译
  作者：Li, Yifan; Lu, Huanhong; Guo, Degang; Li, Xiaoyan; Qi, Fei; Zhang, Jian; Fischer, Reinhard; Shen, Qirong; Yu, Zhenzhong
  作者单位：Nanjing Agricultural University; Xiamen University; Helmholtz Association; Karlsruhe Institute of Technology
  摘要：Light controls important biological processes in fungi by regulating transcriptional gene activation. Here, we found that beyond the regulation of mRNA transcript abundance, light regulates alternative splicing (AS) in the filamentous fungi Aspergillus nidulans, Trichoderma guizhouense, and Neurospora crassa. Blue light-regulated AS was involved in ergothioneine biosynthesis and conidiation in T.guizhouense, which required the blue light receptor BLR1. Blue light activated the MAPK HOG (Sak) p...
• Sp140L functions as a herpesvirus restriction factor suppressing viral transcription and activating interferon- stimulated genes AI翻译
  作者：Cable, Jana M.; Wongwiwat, Wiyada; Grabowski, Jenna C.; White, Robert E.; Luftig, Micah A.
  作者单位：Duke University; Imperial College London
  摘要：Herpesviruses, including Epstein-Barr virus (EBV)-a human oncogenic virus and essential trigger of multiple sclerosis-must bypass host DNA-sensing mechanisms to establish lifelong, latent infection. Therefore, herpesviruses encode viral proteins to disrupt key host factors involved in DNA sensing and viral restriction. The first viral latency protein expressed, EBNA-LP, is essential for transformation of na & iuml;ve B cells and establishment of viral gene expression, yet its role in evading h...