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作者：Mok, Stephen; Liu, Huey; Cobanoglu, Didem Agac; Anang, Nana- Ama A. S.; Mancuso, James J.; Wherry, E. John; Allison, James P.
作者单位：University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Pennsylvania; University of Texas System; UTMD Anderson Cancer Center
摘要：The effects of T cell differentiation arising from immune checkpoint inhibition targeting cytotoxic T lymphocyte-associated antigen 4 (CTLA- 4) and programmed cell death protein 1 (PD- 1) on the immunological memory response remain unclear. Our investigation reveals that memory T cells generated by anti- CTLA- 4 exhibit greater expansion, cytokine preserves more T cell factor- 1 (TCF- 1)+ T cells during priming, while anti- PD- 1 leads to using conditional Tcf7- or Tox- knockout mice highlight...
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作者：Mazigi, Ohan; Langley, David B.; Henry, Jake Y.; Burnett, Deborah L.; Sobti, Meghna; Walker, GregoryJ.; Rouet, Romain; Balachandran, Harikrishnan; Lenthall, Helen; Jackson, Jennifer; Ubiparipovic, Stephanie; Schofield, Peter; Brown, Simon H. J.; Schulz, Sebastian R.; Hoffmann, Markus; Poehlmann, Stefan; Post, Jeffrey; Martinello, Marianne; Ahlenstiel, Golo; Kelleher, Anthony; Rawlinson, William D.; Turville, Stuart G.; Bull, Rowena A.; Stewart, Alastair G.; Jaeck, Hans-Martin; Goodnow, Christopher C.; Christ, Daniel
作者单位：Garvan Institute of Medical Research; University of New South Wales Sydney; University of New South Wales Sydney; Victor Chang Cardiac Research Institute; University of New South Wales Sydney; Prince of Wales Hospital (POWH); University of New South Wales Sydney; Kirby Institute; University of Wollongong; University of Wollongong; University of Erlangen Nuremberg; University of Erlangen Nuremberg; Leibniz Association; Deutsches Primatenzentrum (DPZ); University of Gottingen; University of New South Wales Sydney; NSW Health; Blacktown & Mount Druitt Hospital
摘要：The emergence of SARS-CoV-2 variants of concern (VOCs) has greatly diminished the neutralizing activity of previously FDA- approved monoclonal antibodies (mAbs), including that of antibody cocktails and of first- generation broadly neutralizing antibodies such as S309 (Sotrovimab). In contrast, antibodies targeting cryptic conformational epitopes of the receptor binding domain (RBD) have demonstrated broad activity against emerging variants, but exert only moderate neutralizing activity, which...
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作者：Wang, Tongtong; Huang, Wenze; Xu, Kui; Sun, Yitong; Zhang, Qiangfeng Cliff; Yan, Chuangye; Li, Zhangqiang; Yan, Nieng
作者单位：Tsinghua University; Shenzhen Medical Academy of Research & Translation (SMART); Shenzhen Bay Laboratory
摘要：Despite the recent breakthrough in structure determination and prediction of proteins, the structural investigation of carbohydrates remains a challenge. Here, we report the cryo-EM analysis of a glycofibril found in the freshwater in the Tsinghua Lotus Pond. The fibril, which we name TLP-4, is made of a linear chain of tetrapeptide repeats coated with >4 nm thick glycans. In each repeat, two glycans are O- linked to a 3,4- dihydroxyproline and another glycan attaches to the adjacent Ser or Th...
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作者：Zhou, Songsong; Rappe, Andrew M.
作者单位：University of Pennsylvania
摘要：Ferroelectric hafnia exhibits promising robust polarization and silicon compatibility for ferroelectric devices. Unfortunately, it suffers from difficult polarization switching. Methods to enable easier polarization switching are needed, and the underlying reason for this switching difficulty is not understood. Here, we investigated the 180 degrees domain walls of hafnia and their motion through nucleation. We found that the domains of multiple-order parameter hafnia possess complicated three-...
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作者：Li, Hui; Wang, Ling; Lei, Zhen; Biacsi, Anna-Sara; Jeong, Dong-Hoon; Cho, Jungnam
作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; CRUK Cambridge Institute; Cancer Research UK; University of Cambridge; Duke University; Yale University; Durham University; Hallym University; Hallym University
摘要：Transposable elements (TEs), ubiquitous mobile DNAs, are largely repressed by cellular mechanisms such as epigenetic silencing and RNA decay, yet some retain the ability to transpose. The Arabidopsis long terminal repeat retrotransposon Copia93, also known as Evade, exhibits exceptionally high transpositional activity, but the mechanism underlying its extraordinary mobility remains unclear. Here, we identify an Element for Nuclear Expression (ENE) motif within the 3 ' UTR of Evade that forms a...
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作者：Abdellaoui, Abdel; Wesseldijk, Laura W.; Gordon, Scott D.; Smit, Dirk J. A.; Androvicova, Renata; Martin, Nicholas G.; Ullen, Fredrik; Mosing, Miriam A.; Zietsch, Brendan P.; Verweij, Karin J. H.
作者单位：University of Amsterdam; Karolinska Institutet; University of Melbourne; QIMR Berghofer Medical Research Institute; Karolinska Institutet; National Institute of Mental Health - Czech Republic; University of Queensland
摘要：Romantic (typically sexual) relationships are important to personal, physical, mental, social, and economic well-being, and to human evolution. Yet little is known about factors contributing to long-term lack of intimate relationships. We investigated phenotypic and genetic correlates of never having had sex in similar to 400,000 UK residents aged 39 to 73 and similar to 13,500 Australian residents aged 18 to 89. The strongest associations revealed that sexless individuals were more educated, ...
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作者：Dong, Junkai; Sommer, Ophelia Evelyn; Soejima, Tomohiro; Parker, Daniel E.; Vishwanath, Ashvin
作者单位：Harvard University; University of California System; University of California San Diego
摘要：Recent advances in 2D materials featuring nonzero Berry curvature have inspired extensions of the Wigner crystallization paradigm. This paper derives a low-energy effective theory for such quantum crystals, including the anomalous Hall crystal (AHC) with nonzero Chern number. First, we show that the low frequency dispersion of phonons in AHC, despite the presence of Berry curvature, resembles that of the zero field (rather than finite magnetic field) Wigner crystal due to the commutation of tr...
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作者：Whitridge, Peter
作者单位：Memorial University Newfoundland
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作者：Yuan, Yichuan; Niu, Yi; Huang, Zhenkun; Shi, Yunxing; Lin, Zhu; Zuo, Dinglan; Zhong, Chengrui; Li, Kai; Guan, Xin - Yuan; Yuan, Yunfei; Li, Binkui
作者单位：Sun Yat Sen University; State Key Lab Oncology South China; Sun Yat Sen University; University of Hong Kong
摘要：Hepatocellular carcinoma (HCC) frequently develops resistance to CD8+ T cell-based immunotherapy, yet the mechanisms driving this immune evasion remain poorly understood. To identify tumor-intrinsic regulators of immunotherapy resistance and explore therapeutic strategies to restore T cell-mediated tumor control, we employed three functional genomics approaches using in vitro and in vivo CRISPR screening. Cancer USP14 was identified as the critical immune evasion driver. USP14-high HCC patient...
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作者：Chardac, Amelie; Norton, Michael M.; Touboul, Jonathan; Duclos, Guillaume
作者单位：Brandeis University; Brandeis University; Brandeis University
摘要：Many essential cellular processes, including cell division and the establishment of cell polarity during embryogenesis, are regulated by pattern-forming proteins. These proteins often need to bind to a substrate, such as the cell membrane, onto which they interact and form two-dimensional (2D) patterns. It is unclear how the membrane's continuity and dimensionality impact pattern formation. Here, we address this gap using the MinDE system, a prototypical example of pattern-forming membrane pro...
