2025

最新文章

• S-nitrosylation of pVHL regulates β2 adrenergic receptor function AI翻译
  作者：Grimmett, Zachary W.; Hayashi, Hiroki; Raffay, Thomas M.; Lin, Justin; Premont, Richard T.; Stamler, Jonathan S.
  作者单位：University of Osaka; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; Case Western Reserve University Hospital; University Hospitals of Cleveland
  摘要：The (32- adrenergic receptor ((32AR), a prototype G protein-coupled receptor, controls cardiopulmonary function underpinning O2 delivery. Abundance of the (32AR is canonically regulated by G protein-coupled receptor kinases and (3- arrestins, but neither controls constitutive receptor levels, which are dependent on ambient O2. Basal (32AR expression is instead regulated by the prolyl hydroxylase/pVHL- E3 ubiquitin ligase system, explaining O2 responsivity. Interplay between O2 and nitric oxide...
• Experimentally enhancing dispersal reveals the outsized importance of transient dynamics in a fluctuating environment AI翻译
  作者：Kowalski, Jessica J.; Gilbert, Benjamin; Strauss, Sharon Y.; Germain, Rachel M.
  作者单位：University of British Columbia; University of Toronto; University of California System; University of California Davis
  摘要：The size and composition of local species pools are, in part, determined by past dispersal events. Predicting how communities respond to future disturbances, such as fluctuating environmental conditions, requires knowledge of such histories. We assessed the influence of a historical dispersal event on community assembly by simulating various scales of dispersal for 240 serpentine annual plant communities that experienced a large shift from drought to high rainfall conditions over three years. ...
• Salmonella produces sulfide to compete with Escherichia coli in the gut lumen AI翻译
  作者：Larabi, Anais B.; Tiffany, Connor R.; Masson, Hugo L. P.; Nguyen, Henry; Bejarano, Eli J.; Liou, Megan J.; Radlinski, Lauren C.; Demars, Aurore M.; Tsolis, Renee M.; Baumler, Andreas J.
  作者单位：University of California System; University of California Davis; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania
  摘要：Hydrogen sulfide production is a characteristic that distinguishes Salmonella serovars from closely related species, such as Escherichia coli, but its biological significance remains obscure. Here, we show that PhsABC and AsrABC-mediated hydrogen sulfide production by Salmonella enterica serovar (S.) Typhimurium was linked to an increased abundance of Deltaproteobacteria and inhibition of cytochrome bd oxidase-mediated aerobic respiration of Escherichia coli in the murine large intestine. Func...
• Stress- induced organismal death is genetically regulated by the mTOR-Zeste-Phae1 axis AI翻译
  作者：Matsumura, Takashi; Ryuda, Masasuke; Matsumoto, Hitoshi; Kamiyama, Takumi; Jinnai, Kyoko; Kondo, Shu; Nakamura, Akira; Hayakawa, Yoichi; Niwa, Ryusuke
  作者单位：University of Tsukuba; Saga University; Saga University; Tokyo University of Science; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; Kumamoto University
  摘要：All organisms are exposed to various stressors, which can sometimes lead to organismal death, depending on their intensity. While stress-induced organismal death has been observed in many species, the underlying mechanisms remain unclear. In this study, we investigated the molecular mechanisms of stress-induced organismal death in the fruit fly Drosophila melanogaster. We identified a chymotrypsin-like serine protease Phaedra1 (Phae1) as a death mediator in D. melanogaster larvae. Phae1 expres...
• Muricholic acid mediates puberty initiation via the hypothalamic TGR5 signaling pathway AI翻译
  作者：Wang, Shan; Huang, Ke; Liu, Ana; Wang, Senjie; Jiang, Runqiu; Chen, Wenlian; Wang, Huiying; Ullah, Rahim; Xue, Chuqing; Wu, Wei; Dong, Guanping; Jiang, Peifang; Fu, Junfen; Ni, Yan
  作者单位：Zhejiang University; Nanjing University; Shanghai University of Traditional Chinese Medicine; Zhejiang University
  摘要：The onset of puberty is increasingly observed at earlier ages in children, especially in girls with obesity, a trend that predisposes them to long-term metabolic and reproductive disorders in adulthood. Bile acids have emerged as pivotal signaling molecules in both metabolic and reproductive disorders, but remain unexplored in the early onset of puberty in children. Herein, we find elevated levels of muricholic acid (MCA) species in the serum of girls with central precocious puberty, which str...
• Ice gliding diatoms establish record-low temperature limits for motility in a eukaryotic cell AI翻译
  作者：Zhang, Qing; Leng, Hope T.; Li, Hongquan; Arrigo, Kevin R.; Prakash, Manu
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Stanford University
  摘要：Despite periods of permanent darkness and extensive ice coverage in polar environments, photosynthetic ice diatoms display a remarkable capability of living inside the ice matrix. How these organisms navigate such hostile conditions with limited light and extreme cold remains unknown. Using a custom subzero temperature microscope during an Arctic expedition, we present the finding of motility at record-low temperatures in a Eukaryotic cell. By characterizing the gliding motility of several ice...
• Oyster farming acts as a marine carbon dioxide removal (mCDR) hotspot for climate change mitigation AI翻译
  作者：Chen, Xue- Wei-Jie; Zhang, Zhou; Pan, Miao- Jun; Liu, Yang; Li, Chang-Lin; Zhou, Yan Gen; Li, Li; Dong, Xuan; Dong, Yun-Wei; Li, Jing-Yu; Liu, Su-Mei; Wang, Xiao-Nan; Tian, Shuang- Jie; Liu, Yi; Zhang, Ji- Hong; Qiu, Yan- Guo; Wang, Xue-Gang; Cai, Wei- Jun; Tian, Xiang - Li; Kao, Shuh- Ji; Dong, Shuang- Lin
  作者单位：Ocean University of China; Ocean University of China; Hainan Tropical Ocean University; Ocean University of China; Chinese Academy of Fishery Sciences; Yellow Sea Fisheries Research Institute, CAFS; University of Delaware; Hainan University
  摘要：Bivalve farming, a vital component of global aquaculture, has been proposed as a potential marine carbon dioxide removal (mCDR) strategy, yet its role remains contentious. Using field mesocosms, we demonstrate that oyster filter- feeding enhances mCDR by accelerating the formation of particulate and dissolved organic carbon in the water column and promoting organic carbon deposition in sediments. This process shifts the water column toward a more autotrophic and alkaline state, effectively seq...
• Flavin-deficient erythrocytes offer protection against malaria parasites AI翻译
  作者：Hemasa, Ayman; van Loon, Welmoed; Fu, Jonathan; Spry, Christina; Jager, Julia; van Schalkwyk, Donelly A.; Reverberi, Roberto; Ndoli, Jules; Mockenhaupt, Frank P.; Contini, Carlo; Saliba, Kevin J.
  作者单位：Australian National University; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; University of Ferrara; Arcispedale Sant'Anna; University of Ferrara
  摘要：Studies from the 1980s and 1990s conducted in Italy, where malaria was once endemic, hypothesized that individuals with erythrocytes deficient in flavin mononucleotide and flavin adenine dinucleotide (FAD)-collectively known as flavins-are partially protected against malaria. The condition was reported to be familial, consistent with a genetic element. This hypothesis, however, has never been tested. Using an erythrocyte FAD-dependent glutathione reductase activity assay, we identified individ...
• Broad neutralizing antibody response of a monomeric spike-based SARS-CoV-2 bivalent vaccine against diverse variants AI翻译
  作者：Wang, Siling; Sun, Hui; Wang, Yizhen; Wang, Zikang; Yuan, Lunzhi; Guo, Huilin; Gao, Jiahua; Lan, Miaolin; Wu, Yangtao; Shang, Huixian; Chen, Xiuting; Chen, Zheng; Hu, Jiayi; Tang, Zimin; Wen, Guiping; Ying, Dong; Liu, Chang; Jiang, Yanan; Su, Jinfu; Lin, Min; Wu, Ting; Li, Shaowei; Zhang, Tianying; Zhang, Jun; Guan, Yi; Yuan, Quan; Xia, Ningshao; Zheng, Qingbing; Zhang, Yali; Zheng, Zizheng
  作者单位：Xiamen University; Xiamen University; Xiamen University; University of Hong Kong; Shantou University; Shantou University; University of Hong Kong; Chinese Academy of Medical Sciences - Peking Union Medical College
  摘要：severeacute respiratory syndrome coronavirus 2 (SARS-CoV-2) bivalent vaccines show potential against variants but lack a full understanding of the immunological mechanisms that drive broadly neutralizing antibodies (bnAbs). This study explored the immunogenicity of a bivalent vaccine in rhesus macaques, containing spike (S) proteins from the prototype (Sprototype) and chimeric S protein (S1628x). The vaccine induced bnAbs against multiple variants, including challenging subvariants like EG.1, ...
• Parallel trade-offs in human cognition and neural networks: The dynamic interplay between in-context and in-weight learning AI翻译
  作者：Russin, Jacob; Pavlick, Ellie; Frank, Michael J.
  作者单位：Brown University; Brown University; Brown University
  摘要：Human learning embodies a striking duality: Sometimes, we can rapidly infer and compose logical rules, benefiting from structured curricula (e.g., in formal education), while other times, we rely on an incremental approach or trial-and-error, learning better from curricula that are randomly interleaved. Influential psychological theories explain this seemingly conflicting behavioral evidence by positing two qualitatively different learning systems-one for rapid, rule-based inferences (e.g., in...