2025

最新文章

• Informing does not require attributing ignorance AI翻译
  作者：Royka, Amanda; Santos, Laurie R.
  作者单位：Yale University
• Behavioral sequences across multiple animal species in the wild share common structural features AI翻译
  作者：Minasandra, Pranav; Grout, Emily M.; Brock, Katrina; Crofoot, Margaret C.; Demartsev, Vlad; Gersick, Andrew S.; Hirsch, Ben T.; Holekamp, Kay E.; Johnson-Ulrich, Lily; Nayak, Amlan; Ortega, Josue; Roch, Marie A.; Strauss, Eli D.; Strandburg-Peshkin, Ariana
  作者单位：Max Planck Society; University of Konstanz; Max Planck Society; University of Konstanz; Smithsonian Institution; Smithsonian Tropical Research Institute; Princeton University; James Cook University; Michigan State University; Michigan State University; University of Zurich; Indian Institute of Science Education & Research (IISER) - Mohali; California State University System; San Diego State University
  摘要：Animal behavior can be decomposed into a sequence of discrete activity bouts over time. Analyzing the statistical structure of such behavioral sequences can provide insights into the drivers of behavioral decisions. Laboratory studies, predominantly in invertebrates, have suggested that behavioral sequences exhibit multiple timescales and long-range memory, but whether these results can be generalized to other taxa and to animals natural settings remains unclear. By analyzing accelerometer-inf...
• Paradoxical indeed AI翻译
  作者：Compton, Zachary T.; Vincze, Orsolya; Mellon, Walker; Tollis, Marc; Abegglen, Lisa; Schiffman, Joshua D.; Giraudeau, Mathieu; Boddy, Amy M.; Maley, Carlo C.
  作者单位：Arizona State University; Arizona State University-Tempe; University of Arizona; University of Arizona; HUN-REN; HUN-REN Centre for Ecological Research; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Northern Arizona University; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Huntsman Cancer Institute; University of California System; University of California Santa Barbara; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe
• Intercellular contractile force attenuates chemosensitivity through Notch- MVP- mediated nuclear drug export AI翻译
  作者：Du, Pengyu; Tang, Kai; Chen, Xi; Xin, Ying; Hu, Bin; Meng, Jianfeng; Hu, Guanshuo; Zhang, Cunyu; Li, Keming; Tan, Youhua
  作者单位：Hong Kong Polytechnic University; Hong Kong Polytechnic University; Hong Kong Polytechnic University; Guizhou University of Traditional Chinese Medicine
  摘要：Resistance to chemotherapeutics is one major challenge to clinical effectiveness of cancer treatment and is primarily interpreted by various biochemical mechanisms. This study establishes an inverse correlation between tumor cell contractility and chemosensitivity. In both clinical biopsies and cancer cell lines, high/low actomyosin- mediated contractile force attenuates/enhances the vulnerability to chemotherapy, which depends on intercellular force propagation. Cell-cell interaction force ac...
• Muscle peripheral circadian clock drives nocturnal protein degradation via raised Ror/Rev- erb balance and prevents premature sarcopenia AI翻译
  作者：Kelu, Jeffrey J.; Hughes, Simon M.
  作者单位：University of London; King's College London
  摘要：How central and peripheral circadian clocks regulate protein metabolism and affect tissue mass homeostasis has been unclear. Circadian shifts in the balance between anabolism and catabolism control muscle growth rate in young zebrafish independent of behavioral cycles. Here, we show that the ubiquitin-proteasome system (UPS) and autophagy, which mediate muscle protein degradation, are each upregulated at night under the control of the muscle peripheral clock. Perturbation of the muscle transcr...
• METTL3 mediates atheroprone flow-induced glycolysis in endothelial cells AI翻译
  作者：Zhao, Guo - Jun; Han, So Yun; Li, Yajuan; Yuan, Dongqiang; Qin, Shuo; Li, Yuhan; Jang, Hongje; Chen, Li - Jing; Wei, Tong - You Wade; He, Ming; Li, Yi - Shun; Chen, Zhen Bouman; Shi, Lingyan; Chien, Shu; Shyy, John Y- J.
  作者单位：Zhengzhou University; University of California System; University of California San Diego; University of California System; University of California San Diego; City of Hope; Beckman Research Institute of City of Hope
  摘要：Atheroprone flow-increased glycolysis in vascular endothelial cells (ECs) is pivotal in is a major m6A methyltransferase for RNA N6- mehtyladenosine (m6A) modifications to regulate epitranscriptome and cellular functions. With the atheroprone flow upreguin atheroprone flow-induced glycolysis in ECs in vitro and in vivo. Compared to pulflow) increases METTL3 expression to enhance the m6A modifications of mRNAs encoding HK1, PFKFB3, and GCKR, which are rate- limiting enzymes of glycolysis. while...
• Social dominance in rats is a determinant of susceptibility to stress AI翻译
  作者：Srinivasan, Durga J.; Kapgal, Vijayakumar; Morris, Richard G. M.; Chattarji, Sumantra
  作者单位：Tata Institute of Fundamental Research (TIFR); National Centre for Biological Sciences (NCBS); University of Edinburgh; University of Edinburgh; University of Edinburgh
  摘要：Establishing a dominance hierarchy in social organisms is important for access to resources. Stress has been proposed as a major factor influencing an animal's likely position in a social hierarchy. Although individual differences in vulnerability to stress are increasingly recognized, how social hierarchy affects vulnerability remains relatively understudied. Here, we examined how the social dominance status of adult male Sprague-Dawley rats influences their response to stress in interactions...
• Circadian clock-gated cell renewal controls time-dependent changes in taste sensitivity AI翻译
  作者：Matsu-ura, Toru; Nasu, Atsunori; Lee, Suengwon; Yoshida, Naoko; Matsuura, Kaoru; Yasuda, Masaharu; Nakamura, Kae; Hong, Christian I.; Tsuta, Koji
  作者单位：Kansai Medical University; University System of Ohio; University of Cincinnati; Kansai Medical University; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center
  摘要：Circadian regulation of the cell cycle progression generates a diurnal supply of newborn cells to replace those lost in organs and tissues. In this study, we analyzed circadian time-dependent changes in cell types within the mouse tongue epithelium. Using single-cell RNA sequencing, we observed circadian time-dependent changes in the populations of stem/progenitor cells and the differentiated cells in mice tongues. Notably, we observed time-dependent changes in the type II taste cell populatio...
• Historians use data science to mine the past AI翻译
  作者：Beans, Carolyn
• Possible evidence of excitonic condensation in a topological insulator AI翻译
  作者：Mori, Ryo; Takasan, Kazuaki; Ai, Ping; Ciocys, Samuel; Kawaguchi, Kaishu; Kondo, Takeshi; Morimoto, Takahiro; Lanzara, Alessandra
  作者单位：United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; University of Tokyo; University System of Maryland; University of Maryland College Park; University of Tokyo; University of Tokyo
  摘要：The transient excitonic condensate is a nonequilibrium electron-hole Bardeen- Cooper-Schrieffer state in a photoexcited semiconductor and semimetal, where electron-hole pairs undergo a phase transition and condense into a single coherent quantum state. Despite numerous experimental works to realize the predicted excitonic condensation phase, experimental evidence still remains elusive. This is largely due to the absence of direct measurements of a material's transient momentum-dependent electr...