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作者：Savinov, Andrew; Swanson, Sebastian; Keating, Amy E.; Li, Gene - Wei
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute; Massachusetts Institute of Technology (MIT); Novo Nordisk
摘要：Peptides can bind to specific sites on larger proteins and thereby function as inhibitors and regulatory elements. Peptide fragments of larger proteins are particularly attractive for achieving these functions due to their inherent potential to form native- like binding interactions. Recently developed experimental approaches allow for high- throughput measurement of protein fragment inhibitory activity in living cells. However, it has thus far not been possible to predict de novo which of the...
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作者：Schrom, Edward C.; Mccaffrey, Erin F.; Sreejithkumar, Vivek; Radtke, Andrea J.; Ichise, Hiroshi; Mejias, Armando Arroyo-; Speranza, Emily; Arakkal, Leanne; Thakur, Nishant; Grant, Spencer; Germain, Ronald N.
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Cleveland Clinic Foundation; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
摘要：Spatial patterns of cells and other biological elements drive physiologic and pathologic processes within tissues. While many imaging and transcriptomic methods document tissue organization, discerning these patterns is challenging, especially when they involve multiple elements in complex arrangements. To address this challenge, we present Spatial Patterning Analysis of Cellular Ensembles (SPACE), an R package for analysis of high- plex spatial data. SPACE is compatible with any data collecti...
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作者：Du, Shiyu; Tihelka, Erik; Yu, Daoyuan; Chen, Wan-Jun; Bu, Yun; Cai, Chenyang; Engel, Michael S.; Luan, Yun-Xia; Zhang, Feng
作者单位：Nanjing Agricultural University; Chinese Academy of Sciences; University of Cambridge; Nanjing Agricultural University; American Museum of Natural History (AMNH); Universidad Nacional Mayor de San Marcos; Universidad Nacional Mayor de San Marcos; South China Normal University
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作者：Lei, Lei; Song, Yujun; Yang, Lianyi; Wang, Yazhen; Xia, Xue; Zhang, Yiwei; Zhang, Xiaoxian; Zhang, Xuequan; Duggal, Ishaan; He, Bin; Peppas, Nicholas A.; Cao, Jun; Gao, Huile
作者单位：Sichuan University; Sichuan University; Sichuan University; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
摘要：Carrier- free nanomedicines exhibited significant potential in elevating drug efficacy and safety for tumor management, yet their self assembly typically relied on chemical modifications of drugs or the incorporation of surfactants, thereby compromising the drug's inherent pharmacological activity. To address this challenge, we proposed a triethylamine (TEA)- mediated protonation-deprotonation strategy that enabled the adjustable- proportion self assembly of dual drugs without chemical modific...
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作者：Pedersen, Arthur Paul; Kellen, David; Mayo-Wilson, Conor; Davis-Stober, Clintin P.; Dunn, John C.; Khan, M. Ali; Stinchcombe, Maxwell B.; Kalish, Michael L.; Tentori, Katya; Haaf, Julia
作者单位：City University of New York (CUNY) System; Syracuse University; University of Washington; University of Washington Seattle; University of Missouri System; University of Missouri Columbia; University of Western Australia; Johns Hopkins University; University of Trento; University of Potsdam
摘要：Measurement literacy is required for strong scientific reasoning, effective experimental design, conceptual and empirical validation of measurement quantities, and the intelligible interpretation of error in theory construction. This discourse examines how issues in measurement are posed and resolved and addresses potential misunderstandings. Examples drawn from across the sciences are used to show that measurement literacy promotes the goals of scientific discourse and provides the necessary ...
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作者：Xu, Yue; Gong, Fanglin; Golubovic, Alex; Strilchuk, Amy; Chen, Jingan; Zhou, Muye; Dong, Songtao; Seto, Breanna; Li, Bowen
作者单位：University of Toronto; University of Toronto; University of Toronto; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre
摘要：The ionizable lipid component of lipid nanoparticle (LNP) formulations is essential for mRNA delivery by facilitating endosomal escape. Conventionally, these lipids are synthe-sized through complex, multistep chemical processes that are both time- consuming and require significant engineering. Furthermore, the development of new ionizable lipids is hindered by a limited understanding of the structure- activity relationships essential for effective mRNA delivery. In this work, we have developed...
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作者：Reynier, Emmett; Rubin, Edward
作者单位：University of Oregon; United States Environmental Protection Agency; Oak Ridge Associated Universities; United States Department of Energy (DOE); Oak Ridge Institute for Science & Education
摘要：The advent of herbicide-tolerant genetically modified (GM) crops spurred rapid and widespread use of the herbicide glyphosate throughout US agriculture. In the two decades following GM-seeds' introduction, the volume of glyphosate applied in the United States increased by more than 750%. Despite this breadth and scale, science and policy remain unresolved regarding the effects of glyphosate on human health. We identify the causal effect of glyphosate exposure on perinatal health by combining 1...
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作者：Singh, Matthew F.; Braver, Todd S.; Cole, Michael; Ching, Shinung
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Washington University (WUSTL); Washington University (WUSTL); Rutgers University System; Rutgers University Newark; Rutgers University New Brunswick
摘要：Task-free brain activity affords unique insight into the functional structure of brain network dynamics and has been used to identify neural markers of individual differences. In this work, we present an algorithmic optimization framework that directly inverts and parameterizes brain-wide dynamical-systems models involving hundreds of interacting neural populations, from single-subject M/EEG timeseries recordings. This technique provides a powerful neurocomputational tool for interrogating mec...
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作者：[Anonymous]
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作者：Mcconnell, Joseph R.; Chellman, Nathan J.; Plach, Andreas; Wensman, Sophia M.; Plunkett, Gill; Stohl, Andreas; Smith, Nicole-Kristine; Vinther, Bo Mollesoe; Dahl-Jensen, Dorthe; Steffensen, Jorgen Peder; Fritzsche, Diedrich; Camara-Brugger, Sandra O.; Mcdonald, Brandon T.; Wilson, Andrew I.
作者单位：Nevada System of Higher Education (NSHE); Desert Research Institute NSHE; University of Vienna; Queens University Belfast; Yale University; University of Copenhagen; Niels Bohr Institute; University of Manitoba; Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; University of Basel; Tufts University; University of Oxford; University of Oxford
摘要：Ancient texts and archaeological evidence indicate substantial lead exposure during antiquity that potentially impacted human health. Although lead exposure routes were many and included the use of glazed tablewares, paints, cosmetics, and even intentional ingestion, the most significant for the nonelite, rural majority of the population may have been through background air pollution from mining and smelting of silver and lead ores that underpinned the Roman economy. Here, we determined potent...
