2025

最新文章

• Reply to Ju et al.: Mechanisms of deeper soil organic carbon loss AI翻译
  作者：Zhoua, Zhenghu; Xu, Minggang; Cai, Andong
  作者单位：Northeast Forestry University - China; Northeast Forestry University - China; Chinese Academy of Agricultural Sciences; Institute of Agricultural Resources & Regional Planning, CAAS; Chinese Academy of Agricultural Sciences; Institute of Environment & Sustainable Development in Agriculture, CAAS
• CDKN1B (p27/kip1) enhances drug-tolerant persister CTCs by restricting polyploidy following mitotic inhibitors AI翻译
  作者：Horwitz, Elad; Dubash, Taronish D.; Szabolcs, Annamaria; Wittner, Ben S.; Kreuzer, Johannes; Morris, Robert; Bardia, Aditya; Chirn, Brian; Wiley, Devon; Che, Dante; Russell, Hunter C.; Lopez, Xcanda Ixchel Herrera; Fox, Douglas B.; Antmen, Ezgi; Burr, Risa; Ting, David T.; Haas, Wilhelm; Sade-Feldman, Moshe; Maheswaran, Shyamala; Haber, Daniel A.
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School
  摘要：The mitotic inhibitor docetaxel (DTX) is often used to treat endocrine-refractory metastatic breast cancer, but initial responses are mitigated as patients develop disease progression. Using a cohort of ex vivo cultured circulating tumor cells (CTCs) from patients with heavily pretreated breast cancer (n=18), we find distinct patterns of response to DTX, which are intrinsic and independent of past clinical treatment with taxanes. In some CTC cultures, treatment with a single dose of DTX result...
• Bone morphogenetic protein-9 controls pulmonary vascular growth and remodeling AI翻译
  作者：Berrebeh, Nihel; Mbouamboua, Yvon; Thuillet, Raphael; Ottaviani, Mina; Robert, Fabien; Chelgham, Mustapha Kamel; Magnone, Virginie; Desroches-Castan, Agnes; Ricard, Nicolas; Anegon, Ignacio; Remy, Severine; Schermuly, Ralph Theo; Lebrigand, Kevin; Kojonazarov, Baktybek; Savale, Laurent; Humbert, Marc; Bailly, Sabine; Barbry, Pascal; Tu, Ly; Guignabert, Christophe
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; Universite Paris Saclay; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Cote d'Azur; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); CEA; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Nantes Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Justus Liebig University Giessen; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Antoine-Beclere - APHP; Universite Paris Saclay; Hopital Universitaire Bicetre - APHP; Universite Cote d'Azur
  摘要：Pulmonary arterial hypertension (PAH) and hereditary hemorrhagic telangiectasia (HHT) are two distinct vascular diseases linked to impaired signaling through bone morphogenetic protein (BMP) receptor complexes in endothelial cells. Although BMP-9 plays a central role in activating this pathway by binding to ALK1 and BMPR-II, its precise function in the pulmonary microvasculature has remained unclear. In this study, we demonstrate a role for BMP-9 in regulating pulmonary vascular architecture a...
• The evolution of robustness and fragility during long- term bacterial adaptation (vol 122, e2501901122, 2025) AI翻译
  作者：Chihoub, Doha; Pintard, Coralie; Lenski, Richard E.; Tenaillon, Olivier; Couce, Alejandro
• A bioinspired and degradable riboflavin- containing polypeptide as a sustainable material for energy storage AI翻译
  作者：Li, Shih - Guo; Mohanty, Khirabdhi T.; Easley, Alexandra D.; Rezenom, Yohannes H.; Lim, Soon - Mi; Gillett, Leyla P.; Naquin, Stone D.; Tran, David K.; Nguyen, Tan P.; Lutkenhaus, Jodie L.; Wooley, Karen L.
  作者单位：Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station
  摘要：Inspired by Nature, we present a polypeptide-based organic redox-active material constructed from renewable feedstocks, L-glutamic acid (an amino acid) and riboflavin (vitamin B2), to address challenges with start-to-end-of-life management in energy storage systems (ESSs). The amino acid was utilized to establish a degradable polymer backbone, along which many copies of riboflavin were incorporated to serve as the redox-active pendant groups that enabled energy storage. The overall synthesis i...
• PIK3CA gain-of-function mutation in Schwann cells leads to severe neuropathy and aerobic glycolysis through a non-cell autonomous effect AI翻译
  作者：Venot, Quitterie; Firpion, Marina; Ladraa, Sophia; Bayard, Charles; Magassa, Sato; Di Guardo, Roberta; Fraissenon, Antoine; Hoguin, Clement; Protic, Sanela; Morin, Gabriel; Mayeux, Franck; Gourdon, Genevieve; Fraitag, Sylvie; Balducci, Estelle; Kaltenbach, Sophie; Villarese, Patrick; Asnafi, Vahid; Viel, Thomas; Autret, Gwennhael; Tavitian, Bertrand; Goudin, Nicolas; Guibaud, Laurent; Bolino, Alessandra; Canaud, Guillaume
  作者单位：Universite Paris Cite; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; CHU Lyon; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences (INSIS); Institut National des Sciences Appliquees de Lyon - INSA Lyon; CHU de St Etienne; Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Vita-Salute San Raffaele University
  摘要：PIK3CA-related disorders are rare genetic disorders due to somatic gain-of-function mutations in PIK3CA during embryonic development, a pathway involved in cell growth, proliferation, and metabolism. Accumulating evidence from patients with PIK3CA-related disorders indicates that peripheral nerves are frequently affected, leading to severe neurological symptoms. However, the exact underlying mechanism of these disorders remains unclear. To address this, we developed a mouse model with a PIK3CA...
• Deep origins, distinct adaptations, and species- level status indicated for a glacial relict seal AI翻译
  作者：Loytynoja, Ari; Pohjoismaki, Jaakko; Valtonen, Mia; Laakkonen, Juha; Morita, Wataru; Kunnasranta, Mervi; Vainola, Risto; Olsen, Morten Tange; Auvinen, Petri; Jernvall, Jukka
  作者单位：University of Helsinki; University of Eastern Finland; Natural Resources Institute Finland (Luke); University of Helsinki; National Museum of Nature and Science; Natural Resources Institute Finland (Luke); University of Helsinki; University of Copenhagen; University of Helsinki; University of Helsinki
  摘要：Isolated populations of postglacial relicts are known from many regions and are typically found on mountains for terrestrial species and in lakes for aquatic species. Among the few aquatic mammalian relicts, the Saimaa ringed seal (Pusa hispida saimensis) has been landlocked in Lake Saimaa, Finland, for the last 10,000 y. Saimaa ringed seals show genetic, behavioral, and morphological differences from the other ringed seal subspecies, but the extent these differences stem from the end of the l...
• Deep structure-function analysis of the endonuclease Mus81 with dominant mutational scanning AI翻译
  作者：Oppedisano, Anthony; Bailey, Melanie L.; Kumar, Arun; O' Neil, Nigel J.; Stirling, Peter C.; Hieter, Philip
  作者单位：University of British Columbia; British Columbia Cancer Agency
  摘要：Protein structure-function relationships are critical for understanding molecular mechanisms and the impacts of genetic variation. Mutational scanning approaches can deliver scalable analysis, usually through the study of loss-of-function variants. Rarer dominant negative and gain-of-function variants can be more information rich, as they retain a stable proteoform and can be used to dissect molecular function while retaining biological context. Dominant variant proteoforms can still engage su...
• Global decline of apex scavengers threatens human health AI翻译
  作者：Sonawane, Chinmay; Xu, Maya; Ward, Natalie; Lac, Ariella Chichilnisky du; Kamets, Bohdan; Dirzo, Rodolfo
  作者单位：Stanford University; Stanford University; Stanford University
  摘要：Vertebrate scavengers play a critical role in ecosystem functioning worldwide. Through the cascading effects of their ecological role, scavengers can also alleviate the burden of zoonotic diseases on people. This importance to human health fuels a growing need to understand how vertebrate scavengers and their ecosystem services are faring globally in the Anthropocene. We reviewed the conservation status of 1,376 vertebrate scavenging species and examined the implications for human health. We u...
• Measuring historical pollution: Natural history collections as tools for public health and environmental justice research AI翻译
  作者：DuBay, Shane; Weeks, Brian C.; Davis-Kean, Pamela E.; Fuldner, Carl; Harris, Nyeema C.; Hughes, Sara; O'Brien, Bruce; Perkins, Marie; Weyant, Cheryl
  作者单位：University of Texas System; University of Texas Arlington; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Chicago; Yale University; University of Wisconsin System; University of Wisconsin Stevens Point; University of Chicago
  摘要：Through the industrial era, pollutants have been unevenly distributed intheenvironment, disproportionatelyimpacting disenfranchised communities. Redressing the unequal distribution of environmental pollution is thus a question of environmental justice and public health that requires policy solutions. However, data on pollutants for many locations and time periods are limited because environmental monitoring is largely reactive-i.e., pollutants are monitored only after they are recognized as ha...