2025

最新文章

• Stiffness-gradient adhesive structure with mushroom-shaped morphology via electrically activated one-step growth AI翻译
  作者：Wang, Duorui; Liu, Tianci; Tian, Hongmiao; Zhang, Jinyu; He, Qiguang; Li, Xiangming; Wang, Chunhui; Chen, Xiaoliang; Shao, Jinyou
  作者单位：Xi'an Jiaotong University; Xi'an Jiaotong University; Chinese University of Hong Kong; University of Pennsylvania
  摘要：Reptiles in nature have evolved excellent adhesion systems to adapt to complex natural environments, inspired by which high-performance bioinspired dry adhesives have been consistently created by precisely replicating the natural structures. Stiffness gradient, as a special feature evolved in reptilian adhesion systems, offers significant advantages in enhancing adhesion adaptation and stability.However, it remains a challenge to accurately replicate the geometrical morphology and soft-rigid c...
• Pathogen growth and virulence dynamics drive the host evolution against coinfections AI翻译
  作者：Seal, Srijan; Basu, Dipendra Nath; Ghosh, Kripanjali; Ramachandran, Aryan; Kutum, Rintu; Shelke, Triveni; Gupta, Ishaan; Khan, Imroze
  作者单位：Ashoka University; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Delhi
  摘要：The occurrence of coinfections, where hosts are simultaneously infected by multiple pathogens, is widespread in nature and has significant negative impacts on global health. In humans, over one-sixth of the world's population is affected by coinfections, contributing to several diseases. However, despite the broad ecological relevance and impact on global health, most biomedical research has focused on understanding interactions between a single host and a single pathogen. The extent to which ...
• Iconicity as an organizing principle of the lexicon AI翻译
  作者：Campbell, Erin E.; Sehyr, Zed Sevcikova; Pontecorvo, Elana; Cohen-Goldberg, Ariel; Emmorey, Karen; Caselli, Naomi
  作者单位：Boston University; Chapman University System; Chapman University; Tufts University; California State University System; San Diego State University
  摘要：The view that words are arbitrary is a foundational assumption about language, used to set human languages apart from nonhuman communication. We present here a study of the alignment between the semantic and phonological structure (systematicity) of and Spanish. Across all three languages, words that are semantically related are more likely to be phonologically related, highlighting systematic alignment between word form and word meaning. Critically, there is a significant effect of iconicity ...
• Regulatory mimicry of cyclin- dependent kinases by a conserved herpesvirus protein kinase AI翻译
  作者：Koyanagi, Naoto; Hengphasatporn, Kowit; Kato, Akihisa; Nobe, Moeka; Takeshima, Kosuke; Maruzuru, Yuhei; Maenaka, Katsumi; Shigeta, Yasuteru; Kawaguchi, Yasushi
  作者单位：University of Tokyo; University of Tokyo; University of Tokyo; University of Tsukuba; Hokkaido University; Hokkaido University; University of Tokyo
  摘要：Herpesviruses encode conserved protein kinases (CHPKs) that target dependent kinase (CDK) phosphorylation sites; thus, they are termed kinases. Tyrosine 15 in the GxGxxG motifs of CDK1 and CDK2, whose tion down-regulates their catalytic activities, is conserved in the corresponding CHPKs. We found that CHPK UL13, the corresponding Tyr-162 in virus 2 (HSV-2), was phosphorylated in HSV-2-infected cells. Mutational HSV-2 UL13 Tyr-162 suggested that phosphorylation of UL13 Tyr-162 phosphorylation ...
• Rolling two-dimensional covalent organic framework (COF) sheets into one-dimensional electronic and proton-conductive nanotubes AI翻译
  作者：Li, Zhuowei; Paitandi, Rajendra Prasad; Tsutsui, Yusuke; Matsuda, Wakana; Nobuoka, Masaki; Chen, Bin; Ghosh, Samrat; Tanaka, Takayuki; Suda, Masayuki; Zhu, Tong; Kageyama, Hiroshi; Miyake, Yoshihiro; Shinokubo, Hiroshi; Takagi, Makito; Shimazaki, Tomomi; Tachikawa, Masanori; Suzuki, Katsuaki; Kaji, Hironori; Ando, Yasunobu; Ezaki, Takahiro; Seki, Shu
  作者单位：Kyoto University; Kyoto University; Nagoya University; Yokohama City University; Kyoto University; University of Tokyo
  摘要：Mimicking the interconvertible carbon allotropes of 2-dimensional (2D) graphene and 1-dimensional (1D) carbon nanotubes (CNTs), herein we report the in situ transformation of 2D it-conjugated covalent organic frameworks (COFs) sheet into 1D nanotubular structures via self-assembly the sheets at solvent interfaces. The facile roll-sheets self-assembly resulted in coaxial nanotubes with uniform cross-sectional diameter, which was realized for diazapyrene-based COFs but not for the corresponding ...
• Diet- regulated transcriptional plasticity of plant parasites in plant-mutualist environments AI翻译
  作者：Maxwell, M. Willow H.; Causier, Barry E.; Chippendale, Jasper; Ault, James R.; Bell, Chris A.
  作者单位：University of Leeds; University of Leeds
  摘要：Crop pathogens often lack exclusive access to their host and must interact with plants concurrently engaged with numerous other symbionts. Here, we demonstrate that the colonization of hosts by plant-mutualistic mycorrhizal fungi can indirectly induce transcriptional responses of a major plant parasite, the nematode Globodera pallida, via a modified host resource profile. A shift in the resource profile of the root, where the parasite feeds, is perceived and responded to by the parasite throug...
• Temperature thresholds induce abrupt shifts in biodiversity and ecosystem services in montane ecosystems worldwide AI翻译
  作者：Zeng, Xiao-Min; Berdugo, Miguel; Saez-Sandino, Tadeo; Tao, Dongxue; Ren, Tingting; Zhou, Guiyao; Liu, Yu-Rong; Terrer, Cesar; Reich, Peter B.; Delgado-Baquerizo, Manuel
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Recursos Naturales y Agrobiologia de Sevilla (IRNAS); Huazhong Agricultural University; Chinese Academy of Sciences; Wuhan Botanical Garden, CAS; Complutense University of Madrid; Western Sydney University; Northeast Normal University - China; Nanjing Forestry University; Massachusetts Institute of Technology (MIT); University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Minnesota System; University of Minnesota Twin Cities
  摘要：Montane ecosystems are crucial for maintaining global biodiversity and function that sustain life on our planet. Yet, these ecosystems are highly vulnerable to changing temperatures and may undergo critical transitions under ongoing climate change. What we do not know is to what extent montane biodiversity and ecosystem services will respond to local temperature variations in a gradual versus abrupt manner across global environments. To fill this knowledge gap, we conducted a global synthesis,...
• Inactivation of microglial LXRβ in early postnatal mice impairs microglia homeostasis and causes long- lasting cognitive dysfunction AI翻译
  作者：Lv, Keyi; Luo, Yi; Liu, Tianyao; Xia, Meiling; Gong, Hong; Zhang, Dandan; Chen, Xuan; Jiang, Xin; Liu, Yulong; Liu, Jiayin; Cai, Yulong; Antonson, Per; Warner, Margaret; Xu, Haiwei; Gustafsson, Jan-Ake; Fan, Xiaotang
  作者单位：Army Medical University; Army Medical University; Karolinska Institutet; University of Houston System; University of Houston
  摘要：Microglia, the largest population of brain immune cells, play an essential role in regulating neuroinflammation by removing foreign materials and debris and in cognition by pruning synapses. Since liver X receptor beta (LXR beta) has been identified as a regulator of microglial homeostasis, this study examined whether its removal from microglia affects neuroinflammation and cognitive function. We used a cell-specific tamoxifen-inducible Cre-loxP-mediated recombination to remove LXR beta from m...
• Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit AI翻译
  作者：Paternoga, Helge; Xia, Lu; Paternoga, Lyudmila Dimitrova -; Li, Sihan; Yan, Liewei L.; Oestereich, Malte; Kasvandik, Sergo; Urs, Ankanahalli N. Nanjaraj; Beckert, Bertrand; Tenson, Tanel; Zaher, Hani; Inada, Toshifumi; Wilson, Daniel N.
  作者单位：University of Hamburg; University of Tokyo; Washington University (WUSTL); University of Tartu; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
  摘要：The integrated stress response (ISR) is a central signaling network that enables eukaryotic cells to respond to a variety of different environmental stresses. Such stresses cause ribosome collisions that lead to activation of the kinase Gcn2, resulting in the phosphorylation and inactivation of eukaryotic initiation factor 2 and thereby promoting selective translation of mRNAs to restore homeostasis. Despite the importance of the ISR and intensive study over the past decades, structural insigh...
• Academic achievement helps coordination on mutually advantageous outcomes AI翻译
  作者：Brocas, Isabelle; Carrillo, Juan D.
  作者单位：University of Southern California; Centre for Economic Policy Research - UK
  摘要：This study examines the relationship between academic achievement and strategic ability to coordinate among middle school students. We designed an experimental framework using repeated asymmetric Battle of the Sexes and Hawk-Dove games, to explore how cognitive and social skills related to academic success influence behavior. A total of 132 students participated, divided into groups of high and low academic achievers based on their performance at school. Our results show that, on average, high...