2025

最新文章

• Prospects for cereal self- sufficiency in sub- Saharan Africa AI翻译
  作者：van Ittersuma, Martin K.; Alimagham, Seyyedmajid; Silva, Joao Vasco; Adjei-Nsiah, Samuel; Baijukya, Frederick P.; Bala, Abdullahi; Chikowo, Regis; Grassini, Patricio; de Groot, Hugo L. E.; Nshizirungu, Aphrodis; Soule, Abdelkader Mahamane; Sulser, Timothy B.; Taulya, Godfrey; Tenorio, Fatima Amor; Tesfaye, Kindie; Yuan, Shen; van Loon, Marloes P.
  作者单位：Wageningen University & Research; Swedish University of Agricultural Sciences; University of Ghana; University of Zimbabwe; University of Nebraska System; University of Nebraska Lincoln; Wageningen University & Research; CGIAR; International Food Policy Research Institute (IFPRI); Makerere University; Huazhong Agricultural University
  摘要：Sub-Saharan Africa (SSA) has the world's largest projected increase in demand for food. Increased dependence on imports makes SSA vulnerable to geopolitical and economic risks, while further expansion of agricultural land is environmentally harmful. Cereals, in particular, maize, millet, rice, sorghum, and wheat, take nearly 50% of the cropland and 43% of the calories and proteins consumed in the region. Demand is projected to double until 2050. Here, we assess recent developments in cereal se...
• Circuit complexity and functionality: A statistical thermodynamics perspective AI翻译
  作者：Chamon, Claudio; Ruckenstein, Andrei E.; Mucciolo, Eduardo R.; Canetti, Ran; Coppersmith, Susan
  作者单位：Boston University; State University System of Florida; University of Central Florida; Boston University
  摘要：Circuit complexity, defined as the minimum circuit size required for implementing a particular Boolean computation, is a foundational concept in computer science. Determining circuit complexity is believed to be a hard computational problem. Recently, in the context of black holes, circuit complexity has been promoted to a physical property, wherein the growth of complexity is reflected in the time evolution of the Einstein-Rosen bridge (wormhole) connecting the two sides of an anti-de Sitter ...
• Physics of notochord tube expansion in ascidians AI翻译
  作者：Shi, Wenjie; Duclut, Charlie; Xu, Yan; Ma, Yuanting; Qiao, Jinghan; Lin, Boyan; Yang, Dongyu; Prost, Jacques; Dong, Bo
  作者单位：Ocean University of China; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite PSL; UNICANCER; Institut Curie; Sorbonne Universite; National University of Singapore; Ocean University of China
  摘要：Interaction of cells and the surrounding lumen drives the formation of tubular system that plays the transport and exchange functions within an organism. The physical and biological mechanisms of lumen expansion have been explored. However, how cells communicate and coordinate with the surrounding lumen, leading to continuous tube expansion to a defined geometry, is crucial but remains elusive. In this study, we utilized the ascidian notochord tube as a model to address the underlying mechanis...
• A whole-scale volatile-depleted lunar interior AI翻译
  作者：Dai, Wei; Moynier, Frederic; Long, Zheng- Yu; Fang, Linru; Day, James M. D.; Paquet, Marine; Siebert, Julien
  作者单位：Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); University of Copenhagen; University of California System; University of California San Diego; Scripps Institution of Oceanography; Universite de Lorraine; Centre National de la Recherche Scientifique (CNRS)
  摘要：The extent of moderately volatile elements (MVE) depletion and its effects on the Moon's evolutionary history remain contentious, partly due to unintentionally biased sampling by the Apollo missions from the Procellarum KREEP Terrane. In this study, we analyzed the Zn and K isotope compositions of a series of lunar basaltic meteorites, which vary in Th content and are likely to represent a broader sampling range than previous studies, including samples from the far side of the Moon. Our findin...
• Targeting amyloid-β in glaucoma treatment (vol 104, pg 13444, 2007) AI翻译
  作者：Guo, Li; Salt, Thomas E.; Luong, Vy; Wood, Nicholas; Cheung, William; Maass, Annelie; Ferrari, Giulio; Russo-Marie, Feancoise; Sillito, Adam M.; Cheetham, Michael E.; Moss, Stephen E.; Fitzke, Frederick W.; Cordeiro, M. Francesca
• Maximum spreading of impacting shear-thinning and shear-thickening drops AI翻译
  作者：Mobaseri, Anahita; Kumar, Satish; Cheng, Xiang
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
  摘要：The maximum spreading of an impacting liquid drop is a key metric for characterizing the fundamental fluid process of drop impact. While extensively studied for Newtonian liquids, how far a non-Newtonian drop can spread upon impacting a solid substrate remains an open question. Here, by combining simulations, experiments, and scaling analyses, we establish a general framework for predicting the maximum spreading of drops of generalized Newtonian liquids, encompassing both shear-thinning and sh...
• Reply to Füller et al.: Exome- wide genetic associations with socioeconomic status and their pleiotropy among health outcomes AI翻译
  作者：Wu, Xin-Rui; Yang, Liu; Wu, Bang-Sheng; Cheng, Wei; Yu, Jin-Tai
  作者单位：Fudan University; Fudan University; Fudan University; Fudan University; Fudan University
• Further exploration of the principles and mechanisms of brainwashing AI翻译
  作者：Liu, Haitao; Sun, Haogeng; Liu, Yi
  作者单位：Sichuan University; Sichuan University
• CD83 suppresses endogenous March-I-dependent MHC class II ubiquitination, endocytosis, and degradation AI翻译
  作者：Kaul, Sunil; Cole, Nelson B.; Bandola-Simon, Joanna; Lu, Ying; Tondini, Elena; Walseng, Even; Roche, Paul A.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); AstraZeneca
  摘要：MHC class II glycoproteins (MHC-II) bind peptides derived from exogenous antigens and dendritic cells (DCs) present these peptide MHC-II (pMHC-II) complexes to antigen-specific CD4 T cells during immune responses. The turnover of surface pMHC-II on antigen-presenting cells (APCs) is controlled by ubiquitin-mediated degradation of pMHC-II by the E3 ubiquitin ligase March-I. To study March-I protein expression, we have generated a mouse in which a V5 epitope-tag was knocked-in to the endogenous ...
• MTA-cooperative PRMT5 inhibitors from cofactor-directed DNA-encoded library screens AI翻译
  作者：Anderssona, Jan; Cowlanda, Sanne; Vestergaarda, Mikkel; Yangb, Yajing; Liub, Siyuan; Fangc, Xie; Mukundc, Susmith; Ghimire-Rijalb, Sudipa; Carterb, Chris; Chungb, Grace; Jacsoa, Tomas; Sarvarya, Ian; Hughesb, Paul E.; Gouliaeva, Alex; Paytonb, Marc; Belmontesb, Brian; Caenepeelb, Sean; Francha, Thomas; Glada, Sanne; Husemoena, Birgitte; Nielsena, Soren Jensby
  摘要：Methylthioadenosine phosphorylase (MTAP) gene deletions are frequent in human cancers. Loss ofMTAP leads to significantly increased cellular levels of methylthioadenosine (MTA), a cellular metabolite and specific inhibitor of the cell-essential enzyme Protein Arginine Methyltransferase-5 (PRMT5). Using a cofactor-directed screening strategy and DNA-encoded libraries, we identify a class of PRMT5 inhibitors that cooperatively inhibit PRMT5 in the presence of MTA. An optimized inhibitor, AM-9934...