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作者：Childs, Marissa L.; Lyberger, Kelsey; Harris, Mallory J.; Burke, Marshall; Mordecai, Erin A.
作者单位：University of Washington; University of Washington Seattle; Harvard University; Harvard University; Stanford University; Arizona State University; University System of Maryland; University of Maryland College Park; Stanford University; Stanford University; National Bureau of Economic Research
摘要：Climate change is expected to pose significant threats to public health, particularly vector-borne diseases. Despite dramatic recent increases in dengue that many anecdotally connect with climate change, the effect of anthropogenic climate change on dengue remains poorly quantified. To assess this link, we assembled local-level data on dengue across 21 countries in Asia and the Americas. We found a nonlinear relationship between temperature and dengue incidence with the largest impact of 11 to...
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作者：Dhiman, Shikha; Vleugels, Marle E. J.; Post, Richard A. J.; Crippa, Martina; Cardellini, Annalisa; de Korver, Esmee; Su, Lu; Palmans, Anja R. A.; Pavan, Giovanni M.; van der Hofstad, Remco W.; Albertazzi, Lorenzo; Meijer, E. W.
作者单位：Eindhoven University of Technology; Eindhoven University of Technology; Johannes Gutenberg University of Mainz; Erasmus University Rotterdam; Erasmus MC; Polytechnic University of Turin; Leiden University - Excl LUMC; Leiden University; Eindhoven University of Technology; University of New South Wales Sydney; University of New South Wales Sydney
摘要：Multivalent binding and the resulting dynamical clustering of receptors and ligands are known to be key features in biological interactions. For optimizing biomaterials capable of similar dynamical features, it is essential to understand the first step of these interactions, namely the multivalent molecular recognition between ligands and cell receptors. Here, we present the reciprocal cooperation between dynamic ligands in supramolecular polymers and dynamic receptors in model cell membranes,...
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作者：Kaelin Jr, William G.
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Howard Hughes Medical Institute
摘要：Up to 10 to 20% of the proteome contains regions with much lower amino acid diversity than would be expected by chance. This year's Lasker Basic Science Award is given to Steven McKnight and Dirk G & ouml;rlich for their pioneering work on such low- complexity domains (LCDs). They showed, using a variety of elegant approaches, that such LCDs can form homotypic and heterotypic interactions that lead to reversible phase separations in cells. These phase separations, which in the laboratory manif...
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作者：Turuban, Regis; Noselli, Giovanni; Beran, Alfred; DeSimone, Antonio
作者单位：Scuola Superiore Sant'Anna; International School for Advanced Studies (SISSA); Istituto Nazionale di Oceanografia e di Geofisica Sperimentale
摘要：Aquatic microorganisms typically inhabit a heterogeneous resource landscape, composed of localized and transient patches. To effectively exploit these resources, they have evolved a wide range of feeding strategies that combine chemotactic motility with active feeding flows. However, there is a notable lack of experimental studies that examine how these active flows shape resource fields to optimize feeding. In particular, the suspected cooperative hydrodynamics provided by groups of cells rem...
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作者：Zhang, Jiazhi; Yu, Qin; Tian, Jiazhuang; Yang, Shanglu; Zuo, Xunwei; Li, Ying; Chen, Nailu; Rong, Yonghua; Ritchie, Robert O.; Lu, Jian
作者单位：Chinese Academy of Sciences; Shanghai Institute of Optics & Fine Mechanics, CAS; University of California System; University of California Berkeley; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Jiao Tong University; City University of Hong Kong; City University of Hong Kong; City University of Hong Kong; Shenzhen Research Institute, City University of Hong Kong
摘要：Low-cost yet high-performance structural materials have been invariantly sought for modern engineering applications. However, due to the localized stress concentration induced by a high Peierls-Nabarro stress and limited dislocation mobility, increasing material strength usually comes at the expense of ductility and toughness, resulting in a trade-off between strength-ductility/strength-toughness. Here, we report an anomalous phenomenon of dislocation absorption at the crack front, which is un...
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作者：Haga, Saori; Nozawa, Kaori; Abbasi, Ferheen; Kent, Katarzyna; Nagasawa, Naoko; Endo, Tsutomu; Miyata, Haruhiko; Ikawa, Masahito; Matzuk, Martin M.; Fujihara, Yoshitaka
作者单位：National Cerebral & Cardiovascular Center - Japan; University of Osaka; University of California System; University of California Davis; Baylor College of Medicine; University of Tokyo; University of Osaka; University of Tokyo
摘要：In mammals, sperm formation is completed in the seminiferous tubules within the testis, and sperm maturation occurs during the epididymal transit of the spermatozoa. Sperm morphology drastically changes when abnormal spermatozoa migrate from the testis to the epididymis. Detailed molecular mechanisms for sperm survival in the epididymis have not been determined yet. Globozoospermia is a cause of male infertility and is characterized by round-headed spermatozoa without acrosomes, an abnormal sp...
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作者：Leung, Alan W.; Wong, Sandra Y.; Zhang, Janet C.; Leung, Keith K. H.; Dung, Nelson W. F.; Shang, Catherine A.; Prall, Owen W.; Nim, Hieu T.; See, Michael; Ramialison, Mirana; Chan, Danny; Mohun, Timothy J.; Harvey, Richard P.; Tam, Patrick P. L.; Cheah, Kathryn S. E.
作者单位：University of Hong Kong; University of Hong Kong; Francis Crick Institute; Victor Chang Cardiac Research Institute; University of Melbourne; Murdoch Children's Research Institute; University of Melbourne; Monash University; Australian Regenerative Medicine Institute; Monash University; University of New South Wales Sydney; University of New South Wales Sydney; University of Sydney; Children's Medical Research Institute - Australia; University of Sydney
摘要：Cardiogenesis relies on the integrated interplay between cardiac transcription factors and signaling pathways. Here, we uncover a role for type IIA procollagen (IIA), an extracellular matrix (ECM) protein encoded by an alternatively spliced Col2a1 transcript, encoding a N-terminal cysteine-rich domain, as a critical regulator in a cardiac gene regulatory feedback loop. The cysteine-rich domain of IIA protein was previously reported to interact with bone morphogenetic proteins (BMPs) and transf...
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作者：Sun, Gangyu; Li, Xiang; Hu, Jiaojiao; Yang, Tianbin; Liu, Cong; Wang, Zhizhi; Li, Dan; Xu, Wenqing
作者单位：ShanghaiTech University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Fudan University
摘要：Pathological aggregation of transactive response DNA binding protein of 43 kDa (TDP-43), primarily driven by its low-complexity domain, is closely associated with various neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Despite the therapeutic potential of preventing TDP-43 aggregation, no effective small molecule or biomacromolecule therapeutics have been successfully developed so far. Here, we introduce a protein design s...
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作者：Zhang, Shijie; Fei, Chenyi; Dunkel, Jorn
作者单位：Massachusetts Institute of Technology (MIT)
摘要：Regulation of cell growth and division is essential to achieve cell-size homeostasis. Recent advances in imaging technologies, such as mother machines for bacteria or yeast, have allowed long-term tracking of cell-size dynamics across many generations, and thus have brought major insights into the mechanisms underlying cell-size control. However, understanding the governing rules of cell growth and division within a quantitative dynamical-systems framework remains a major challenge. Here, we i...
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作者：Zhang, Zhifen; Zhang, Minquan; Burnap, Robert L.
作者单位：Oklahoma State University System; Oklahoma State University - Stillwater
摘要：Cyanobacteria achieve highly efficient photosynthesis using a CO2-concentrating mechanism relying on specialized Type I (NDH-1) complexes. Among these, NDH-1(3) and NDH-1(4) catalyze redox-coupled hydration of CO2 to bicarbonate, supporting carbon fixation in carboxysomes. The mechanism of coupling electron transfer to CO2-hydration by these variant NDH-1 complexes remains unknown. We engineered a Synechococcus PCC7942 strain that expresses exclusively the high flux/low affinity NDH-1(4) compl...
