-
作者：Rogers, Stephen M.; Cullen, Darron A.; Labonte, David; Sutton, Gregory P.; Vanden Broeck, Jozef J. M.; Burrows, Malcolm
作者单位：University of Cambridge; University of Lincoln; KU Leuven; University of Hull; Imperial College London; University of Cambridge
摘要：Resilin, an elastomeric protein with remarkable physical properties that outperforms synthetic rubbers, is a near- ubiquitous feature of the power amplification mechanisms used by jumping insects. Catapult- like mechanisms, which incorporate elastic energy stores formed from a composite of stiff cuticle and resilin, are frequently used by insects to translate slow muscle contractions into rapid- release recoil movements. The precise role of resilin in these jumping mechanisms remains unclear, ...
-
作者：Sciortino, Francesco
作者单位：Sapienza University Rome
-
作者：Zhou, Zhongneng; Chen, Zijing; Kang, Xiu-Wen; Ding, Bei; Zou, Shuhua; Tang, Siwei; Zhou, Yalin; Wang, Bingyao; Zhong, Dongping
作者单位：Shanghai Jiao Tong University
摘要：Class II photolyases (PLs) are a distant subclade in the photolyase/cryptochrome superfamily, displaying a unique Trp-Tyr tetrad for photoreduction and exhibiting a lower quantum yield (QY) of DNA repair (49%) than class I photolyases (82%) [M. Zhang, L. Wang, S. Shu, A. Sancar, D. Zhong, Science 354, 209-213 (2016)]. Using layer-by-layer mutant design and femtosecond spectroscopy, we have successfully determined the rates of electron transfer and proton transfer, driving force, and reorganiza...
-
作者：Ashton, Michael C.; Lee, Kibeom
作者单位：Brock University; University of Calgary
摘要：We examined associations of self- reports on the HEXACO Personality Inventory-Revised (HEXACO-PI-R) with birth order category and sibship size, controlling for participant sex and age. In a first sample (N > 700,000 online adults, mainly from English- speaking countries), Honesty- Humility and Agreeableness both showed the highest means for middle-borns, followed in order by last-borns (youngests), firstborns (oldests), and only children, with differences between middles and onlys of d >= 0.20...
-
作者：Cooke, Dylan F.
作者单位：Simon Fraser University; Simon Fraser University
-
作者：Ruiz, Nestor; Hendrixson, David R.
作者单位：University of California System; University of California Los Angeles
摘要：Canonical bacterial two-component signal transduction systems (TCSs) detect cues by sensors with opposing kinase and phosphatase activities to alter the level of phosphorylation of cognate response regulators to mediate responses. We previously identified the Campylobacter jejuni BumSR TCS as the founding member of a bacterial TCS family in which the sensor solely functions as a phosphatase. Sensing specific intestinal metabolites inhibits BumS dephosphorylation of phospho-BumR (P-BumR) to imp...
-
作者：Sadayappan, Kayalvizhi; Li, Li
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
摘要：While air heat waves often grab headlines, riverine heat waves have gone quietly unnoticed because rivers are commonly perceived as cool refuges. Analysis of riverine heat waves has been hindered by fragmented datasets, despite a proliferation in water-temperature monitoring with sensors and satellites. Here, we analyze riverine heat wave events by training one single deep learning (long short-term memory) model and reconstructing consistent and continuous daily water temperatures (WT) in 1471...
-
作者：Ben-Michael, Eli; Greiner, D. James; Huang, Melody; Imai, Kosuke; Jiang, Zhichao; Shin, Sooahn
作者单位：Carnegie Mellon University; Carnegie Mellon University; Harvard University; Yale University; Yale University; Harvard University; Harvard University; Sun Yat Sen University
摘要：The use of AI, or more generally data-driven algorithms, has become ubiquitous in today's society. Yet, in many cases and especially when stakes are high, humans still make final decisions. The critical question, therefore, is whether AI helps humans make better decisions compared to a human-alone or AI-alone system. We introduce a methodological framework to answer this question empirically with minimal assumptions. We measure a decision maker's ability to make correct decisions using standar...
-
作者：Murakami, Tatsuya C.; Belenko, Nick; Dennis, Griffin; Wang, Cuidong; Siantoputri, Maria Esterlita; Maeda, Yurie; Pressl, Christina; Heintz, Nathaniel
作者单位：Rockefeller University; Rockefeller University
摘要：Fluorescence imaging enables visualization of the specific molecules of interest with high contrast, and the use of multiple fluorophores in a single tissue sample allows visualization of complex relationships between biological molecules, cell types, and anatomy. The utility of fluorescence imaging in human tissue has been limited by endogenous pigments that can block the light path or emit an autofluorescence, thereby interfering with the specific imaging of target molecules. Although photob...
-
作者：Samir, Sherihan; Elshereef, Abdalla A.; Alva, Vikram; Hahn, Jeanette; Eck, Frederik; Celma, Louisa; Lopes, Eduardo S.; Thormann, Kai; Dubnau, David; Galperin, Michael Y.; Selim, Khaled A.
作者单位：Eberhard Karls University of Tubingen; Egyptian Knowledge Bank (EKB); Ain Shams University; Egyptian Knowledge Bank (EKB); National Research Centre (NRC); Max Planck Society; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University Newark; Rutgers University System; Rutgers University Newark; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Justus Liebig University Giessen; Heinrich Heine University Dusseldorf; National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM); Division of Intramural Research (DIR)
摘要：Cyclic dimeric-GMP (c-di-GMP) is a ubiquitous bacterial second messenger that regulates a variety of cellular processes, including motility, biofilm formation, secretion, cell cycle progression, and development, and also contributes to the virulence of many bacterial pathogens. While the genes encoding c-di-GMP cyclases and hydrolases are readily identifiable in microbial genomes, known c-di-GMP receptor domains are quite few, with only PilZ and MshEN broadly distributed across bacterial phyla...
