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作者：Sun, Liangzhan; Hu, Pengchao; Yang, Hui; Ren, Jun; Hu, Rong; Wu, Shasha; Wang, Yanchen; Du, Yuyang; Zheng, Jingyi; Wang, Fenfen; Gao, Han; Yan, Jingsong; Yuan, Yun-Fei; Guan, Xin-Yuan; Xiao, Jia; Li, Yan
作者单位：Southern University of Science & Technology; University of Hong Kong; University of Hong Kong; Shenzhen Bay Laboratory; Peking University Shenzhen Graduate School (PKU Shenzhen); Peking University; Hubei University of Medicine; Southern Medical University - China; State Key Lab Oncology South China; Sun Yat Sen University; Jinan University
摘要：ADAR is highly expressed and correlated with poor prognosis in hepatocellular carcinoma (HCC), yet the role of its constitutive isoform ADARp110 in tumorigenesis remains elusive. We investigated the role of ADARp110 in HCC and underlying mechanisms using clinical samples, a hepatocyte- specificAdarp110 knock- in mouse model, and engineered cell lines. ADARp110 is overexpressed and associated with poor survival in both human and mouse HCC. It creates an immunosuppressive microenvironment by inh...
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作者：Ala-Laurila, Petri
作者单位：University of Helsinki; Aalto University
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作者：Couper, Lisa I.; Dodge, Tristram O.; Hemker, James A.; Kim, Bernard Y.; Alonso, Moi Exposito-; Brem, Rachel B.; Mordecai, Erin A.; Bitter, Mark C.
作者单位：Stanford University; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Howard Hughes Medical Institute; University of California System; University of California Berkeley
摘要：Climate warming is expected to shift the distributions of mosquitoes and mosquito- borne diseases, promoting expansions at cool range edges and contractions at warm range edges. However, whether mosquito populations could maintain their warm edges through evolutionary adaptation remains unknown. Here, we investigate the potential for thermal adaptation in Aedes sierrensis, a congener of the major disease vector species that experiences large thermal gradients in its native range, by assaying t...
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作者：Lim, Kang Rui Garrick; Kaiser, Selina K.; Herring, Connor J.; Kim, Taek - Seung; Perich, Marta Perxes; Garg, Sadhya; O'Connor, Christopher R.; Aizenberg, Michael; van der Hoeven, Jessi E. S.; Reece, Christian; Montemore, Matthew M.; Aizenberg, Joanna
作者单位：Harvard University; Harvard University; Tulane University; Harvard University; Utrecht University
摘要：Despite the broad catalytic relevance of metal-support interfaces, controlling their chemical nature, the interfacial contact perimeter (exposed to reactants), and consequently, their contributions to overall catalytic reactivity, remains challenging, as the nanoparticle and support characteristics are interdependent when catalysts are prepared by impregnation. Here, we decoupled both characteristics by using a raspberry- colloid- templating strategy that yields partially embedded PdAu nanopar...
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作者：Liu, Jingjun; Hardisty, Dalton S.; Kasting, James F.; Fakhraee, Mojtaba; Planavsky, Noah J.
作者单位：Yale University; Michigan State University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
摘要：The origin of complex life and the evolution of terrestrial ecosystems are fundamental aspects of the natural history on Earth. Here, we present evidence for a protracted stabilization of the Earth's ozone layer. The destruction of atmospheric ozone today is inherently linked to the cycling of marine and atmospheric iodine. Supported by multiple independent lines of geological evidence and examined through an iodine mass balance model, we find that elevated marine iodide content prevailed thro...
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作者：Lockhart, Jeffrey W.; Fuentes, Agustin; Rippon, Gina; Eliot, Lise
作者单位：University of Chicago; Princeton University; Aston University; Rosalind Franklin University of Medicine & Science; Chicago Medical School
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作者：Weiss, Benjamin P.; Mansbach, Elias N.; Maurel, Clara; Sprain, Courtney J.; Hysell, Nicholas L. Swanson-; Williams, Wyn
作者单位：Massachusetts Institute of Technology (MIT); Institut de Recherche pour le Developpement (IRD); INRAE; Aix-Marseille Universite; State University System of Florida; University of Florida; University of California System; University of California Berkeley; University of Edinburgh
摘要：The Red Planet is a magnetic planet. The Martian crust contains strong magnetization from a core dynamo that likely was active during the Noachian period when the surface may have been habitable. The evolution of the dynamo may have played a central role in the evolution of the early atmosphere and the planet's transition to the current cold and dry state. However, the nature and history of the dynamo and crustal magnetization are poorly understood given the lack of well- preserved, oriented, ...
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作者：Furth, Noa; Cohen, Niv; Spitzer, Avishay; Salame, Tomer- Meir; Dassa, Bareket; Mehlman, Tevie; Brandis, Alexander; Moussaieff, Arieh; Friedmann-Morvinski, Dinorah; Castro, Maria G.; Fortin, Jerome; Suva, Mario L.; Tirosh, Itay; Erez, Ayelet; Ron, Guy; Shema, Efrat
作者单位：Weizmann Institute of Science; Weizmann Institute of Science; Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky Medical Center; Tel Aviv University; Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science; Hebrew University of Jerusalem; Tel Aviv University; University of Michigan System; University of Michigan; McGill University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Hebrew University of Jerusalem
摘要：Malignant gliomas are heterogeneous tumors, mostly incurable, arising in the central nervous system (CNS) driven by genetic, epigenetic, and metabolic aberrations. Mutations in isocitrate dehydrogenase (IDH1/2mut) enzymes are predominantly found in low- grade gliomas and secondary high- grade gliomas, with IDH1 mutations being more prevalent. Mutant-IDH1/2 confers a gain- of- function activity that favors the conversion of a- ketoglutarate (ox- KG) to the oncometabolite 2- hydroxyglutarate (2-...
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作者：Johnson, Nicole A.; Dickenson, Jessica A.; Mackenzie, Benjamin W. L.; Isakovich, Rodion; Kalker, Anne; Bouten, Janne; Strzalkowski, Nicholas D. J.; Harman, Taylor S.; Kunwar, Ajaya J.; Thakur, Nilam; Dhungel, Sunil; Sherpa, Nima; Bigham, Abigail W.; Brutsaert, Tom D.; Day, Trevor A.; Holmstroem, Pontus
作者单位：Mount Royal University; Radboud University Nijmegen; Ghent University; Syracuse University; Mid-Sweden University
摘要：With over 14 million people living above 3,500 m, the study of acclimatization and adaptation to high altitude in human populations is of increasing importance, where exposure to high altitude (HA) imposes a blood oxygenation and acid-base challenge. A sustained and augmented hypoxic ventilatory response protects oxygenation through ventilatory acclimatization, but elicits hypocapnia and respiratory alkalosis. A subsequent renally mediated compensatory metabolic acidosis corrects pH toward bas...
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作者：Martin-Roca, Jose; Barriuso, G. C. Miguel; Fernandez, Raul Martinez; Giuliano, Camila Betterelli; Zhang, Rongjin; Valeriani, Chantal; Wilson, Laurence G.
作者单位：Complutense University of Madrid; Chinese Academy of Sciences; University of Science & Technology of China, CAS; University of York - UK
摘要：Carnivory in plants is an unusual trait that has arisen multiple times, independently, throughout evolutionary history. Plants in the genus Genlisea are carnivorous and feed on microorganisms that live in soil using modified subterranean leaf structures (rhizophylls). A surprisingly broad array of microfauna has been observed in the plants' digestive chambers, including ciliates, amoebae, and soil mites. Here, we show, through experiments and simulations, that Genlisea exploit active matter ph...
