2025

最新文章

• Global warming drives a threefold increase in persistence and 1 °C rise in intensity of marine heatwaves AI翻译
  作者：Marcos, Marta; Amores, Angel; Agulles, Miguel; Robson, Jon; Feng, Xiangbo
  作者单位：Universitat de les Illes Balears; Universitat de les Illes Balears; University of Reading; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC National Centre for Atmospheric Science
  摘要：Marine heatwaves are extreme climatic events consisting of persistent periods of warm ocean waters that have profound impacts on marine life. These episodes are becoming more intense, longer, and more frequent in response to anthropogenic global warming. Here, we provide a comprehensive and quantitative assessment on the role of global warming on marine heatwaves. To do so, we construct a counterfactual version observed global sea surface temperatures since 1940, corresponding to a stationary ...
• Is killing animals an effective way to regulate populations? AI翻译
  作者：McDermott, Amy
• Vortex reversal is a precursor of confined bacterial turbulence (vol 122, e2414446122, 2025) AI翻译
  作者：Nishiguchi, Daiki; Shiratani, Sora; Takeuchi, Kazumasa A.; Aranson, Igor S.
• The importance of playing the long game when it comes to pandemic surveillance AI翻译
  作者：Shearer, Freya M.; Lipsitch, Marc
  作者单位：University of Melbourne; The Kids Research Institute Australia; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard T.H. Chan School of Public Health
• Cancer-associated SF3B1 mutation K700E causes widespread changes in U2/branchpoint recognition without altering splicing AI翻译
  作者：Damianov, Andrey; Lin, Chia-; Zhang, Jian; Manley, James L.; Black, Douglas L.
  作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Columbia University
  摘要：Myelodysplastic syndromes and other cancers are often associated with mutations in the U2 snRNP protein SF3B1. Common SF3B1 mutations, including K700E, disrupt SF3B1 interaction with the protein SUGP1 and induce aberrant activation of alternative 3 ' splice sites (ss), presumably resulting from aberrant U2/branch site (BS) recognition by the mutant spliceosome. Here, we apply a method of U2 IP-seq to profile BS binding across the transcriptome of K562 leukemia cells carrying the SF3B1 K700E mu...
• Mechanistic insights into dengue virus inhibition by a clinical trial compound NITD-688 AI翻译
  作者：Wang, Yan; Sun, Long; Fernandes, Luciana; Wang, Yu-Hsiu; Zou, Jing; Franklin, Samuel J.; Hu, Yanping; Palmer, Lee K.; Yeung, Jason; Barriga, Daniela; Russell, William K.; Moquin, Stephanie A.; Shi, Pei-Yong; Skepper, Colin; Xie, Xuping
  作者单位：University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; Novartis; Novartis USA; University of Texas System; University of Texas Medical Branch Galveston
  摘要：Dengue, caused by the dengue virus (DENV), presents a significant public health challenge with limited effective treatments. NITD-688 is a potent panserotype DENV inhibitor currently in Phase II clinical trials. However, its mechanism of action is not fully understood. Here, we present the molecular details of how NITD-688 inhibits DENV. NITD-688 binds directly to the nonstructural protein 4B (NS4B) with nano-molar affinities across all four DENV serotypes and specifically disrupts the interac...
• Populations of large-diameter trees are increasing across the United States AI翻译
  作者：Chisholm, Paul J.; Gray, Andrew N.
  作者单位：United States Department of Agriculture (USDA); United States Forest Service
  摘要：Large-diameter trees provide vital ecological functions in forested ecosystems. Old, large-diameter trees may also be vulnerable to climate-driven mortality events, but past work on large tree populations has been geographically limited. Here, we characterize the population of large-diameter trees from two size categories, 50 to 100 cm diameter at breast height (DBH) (medium) and >100 cm DBH (big), within the United States using Forest Inventory and Analysis data. Although populations of big t...
• Asymmetric bending boundary layer: The λ-test AI翻译
  作者：Vani, Nathan; Ibarra, Alejandro; Bico, Jose; Reyssat, Etienne; Roman, Benoit
  作者单位：Sorbonne Universite; Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Universite Paris Cite
  摘要：We investigate the mechanics of two asymmetric ribbons bound at one end and pulled apart at the other ends. We characterize the elastic junction near the bonding and conceptualize it as a bending boundary layer. While the size of this junction decreases with the pulling force, we observe the surprising existence of the binding angle as a macroscopic signature of the bending stiffnesses. Our results thus challenge the standard assumption of neglecting bending stiffness of thin shells at large t...
• Blobs form during the single- file transport of proteins across nanopores (vol 121, e2405018121, 2024) AI翻译
  作者：Sauciuc, Adina; Whittaker, Jacob; Tadema, Matthijs; Tych, Katarzyna; Guskov, Albert; Maglia, Giovanni
• RNA- targeted proteomics identifies YBX1 as critical for efficient HCMV mRNA translation AI翻译
  作者：Dickmander, Rebekah J.; Lenarcic, Erik M.; Sears, John D.; Hale, Andrew E.; Moorman, Nathaniel J.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
  摘要：Viruses have evolved unique strategies to circumvent host control of protein synthesis and enable viral protein synthesis in the face of the host response. Defining the factors that regulate viral messenger RNA (mRNA) translation is thus critical to understand how viruses replicate and cause disease. To identify factors that might regulate viral mRNA translation, we developed a technique for identifying proteins associated with a native RNA expressed from its endogenous promoter and genomic lo...