2025

最新文章

• Dual- laser 808 and 1,064 nm strategy that circumvents the Achilles' heel of photothermal therapy AI翻译
  作者：Ding, Qihang; Liu, Jiqiang; Wang, Yue; Kim, Jungryun; Huang, Zhihui; Lee, Yubin; Zhou, Hui; Zhang, Pengfei; Sessler, Jonathan L.; Kim, Jong Seung
  作者单位：Korea University; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Nanjing University of Posts & Telecommunications; University of Texas System; University of Texas Austin
  摘要：Breast cancer has now overtaken lung cancer as the world's leading cancer, yet detecting and implementing effective therapies remains a significant challenge. Substantial advances have been made in photothermal therapy (PTT), where photosensitizers use photonic energy to induce localized hyperthermia for cancer eradication. This pioneering approach is gaining traction in clinical settings. However, traditional PTT faces inherent limitations, including the risk of damage to neighboring healthy ...
• Targeted apoptotic immune modulator for the treatment of metastatic EGFR-positive solid tumors AI翻译
  作者：Broka, Derrick; Klein, Shoshana; Shir, Alexei; Schade, Babette; Saxena, Meera; Dasargyri, Athanasia; Jarzebinska, Anita; De Feyter, Caroline; Bajic, Davor; Colecchia, David; Amico, Lucia D.; Kitas, Eric; Hikri, Elad; Skowicki, Michal Jerzy; Okoniewski, Michal Jerzy; Baldino, Laura; Qeriqi, Besnik; de Stanchina, Elisa; Schreiber, Joerg; Buchi, Melanie; Palivan, Cornelia G.; Benenson, Yaakov; Zippelius, Alfred; Fabbro, Doriano; Scaltriti, Maurizio; Mizrachi, Aviram; Levitzki, Alexander; Pombo-Villar, Esteban; Zigler, Maya
  作者单位：Hebrew University of Jerusalem; Rabin Medical Center; Tel Aviv University; Rabin Medical Center; Tel Aviv University; University of Basel; Swiss Federal Institutes of Technology Domain; ETH Zurich; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Basel
  摘要：Aberrant activation and overexpression of the epidermal growth factor receptor (EGFR) occurs in various solid cancers and often correlates with poor outcome. The clinical benefit from EGFR-targeted therapies is usually short-lived, with resistance being driven by tumor heterogeneity and an immunosuppressive tumor microenvironment (TME). To address these limitations, we developed Targeted Apoptotic Immune Modulators (TAIM), a nonviral nanoparticle platform for the targeted delivery of polyinosi...
• Can increasing the size and flexibility of a molecule reduce decoherence and prolong charge migration? AI翻译
  作者：Scheidegger, Alan; V. Golubev, Nikolay; Makri, Nancy
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Arizona
  摘要：Coherent superposition of electronic states, created by ionizing a molecule, can initiate ultrafast dynamics of the electron density. Correlation between nuclear and electron motions, however, typically dissipates the electronic coherence in only a few femtoseconds, especially in larger and more flexible molecules. We, therefore, use ab initio semiclassical dynamics to study decoherence in a sequence of analogous organic molecules of increasing size and find, surprisingly, that extending the c...
• Deciphering Ca2+permeation and valence selectivity in CaV1: Molecular dynamics simulations reveal the three-ion knock-on mechanism AI翻译
  作者：Xue, Lingfeng; Yan, Nieng; Song, Chen
  作者单位：Peking University; Tsinghua University; Shenzhen Medical Academy of Research & Translation (SMART); Shenzhen Bay Laboratory
  摘要：Voltage-gated calcium (CaV) channels are pivotal in cellular signaling due to their selective calcium ion permeation upon membrane depolarization. While previous studies have established the highly selective permeability of CaV channels, the detailed molecular mechanism remains elusive. Here, we use extensive atomistic molecular dynamics simulations to elucidate the mechanisms governing ion permeation and valence selectivity in CaV1 channels. Employing the electronic continuum correction metho...
• Himalayan S-type granite generated from I-type sources AI翻译
  作者：Ding, Huixia; Zhang, Zeming; Kohn, Matthew J.
  作者单位：China University of Geosciences; China University of Geosciences; China Geological Survey; Institute of Geology, Chinese Academy of Geological Sciences; Chinese Academy of Geological Sciences; Boise State University
  摘要：Partial melting of metasedimentary rocks is generally accepted as the source of peraluminous Himalayan leucogranites-they are commonly considered as pure S-type (sedimentary source) granites. Here, a uniquely comprehensive geochronological and geochemical dataset shows that partial melting of metaigneous rocks in the eastern Himalaya produced peraluminous leucogranites-these supposed S-type leucogranites have I-type (igneous) sources. Inherited magmatic zircons from leucogranites and metaigneo...
• Barremian tricolpate pollen from Portugal-New evidence for the age of eudicot-related angiosperms AI翻译
  作者：Gravendyck, Julia; Riding, James B.; Coimbra, Rute; Heimhofer, Ulrich
  作者单位：Leibniz University Hannover; University of Bonn; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Geological Survey; Universidade de Aveiro
  摘要：New evidence on the timing of early angiosperm evolution is presented through the discovery of four well-dated tricolpate pollen grains from the Early Cretaceous midlatitudes. Recovered from nearshore marine sediments in the Lusitanian Basin of Portugal, these fossils significantly expand the pre-Aptian tricolpate pollen record and document a greater number of pre-Aptian tricolpate grains in the midlatitudes than previously recognized. The fossil evidence was obtained through the innovative ap...
• Autocatalytic symmetry breaking and chiral amplification in a feedback network combining amino acid synthesis and ligation AI翻译
  作者：Higgs, Paul G.; Blackmond, Donna G.
  作者单位：McMaster University; Scripps Research Institute
  摘要：A kinetic model coupling prebiotically plausible synthesis of enantioenriched proteinogenic amino acids with catalytic peptide ligation leads to an autocatalytic network that may exhibit symmetry breaking and chiral amplification, providing a feasible route to the emergence of biological homochirality. We show that symmetry breaking leading to chiral amplification can occur in two ways: a constructive mechanism in which dimers catalyze the synthesis of monomers of the same enantiomer, and a de...
• Everyday challenges to women's presence and authority yield greater burnout and less persistence in a male- dominated profession AI翻译
  作者：Williams, Melissa J.; Esianor, Brandon; Hendrick, Sara; Farlow, Janice L.; Farrell, Annie; Kupfer, Robbi A.; Meyer, Tanya K.; Vinson, Kimberly N.; Wandell, Grace M.; Chen, Amy Y.
  作者单位：Emory University; Medical University of South Carolina; University of Northern Colorado; Indiana University System; Indiana University Indianapolis; Emory University; University of Michigan System; University of Michigan; University of Washington; University of Washington Seattle; Vanderbilt University; Swedish Medical Center
  摘要：While most people believe that women (vs. men) experience more discriminatory treatment at work, especially in male-dominated professions, relatively few women report experiencing such treatment themselves. These low levels of reporting may arise either because discriminatory treatment has declined, even while laypeople's assumptions of widespread discrimination persist, or because it is difficult for individuals to know when they are experiencing discriminatory treatment, leading to underrepo...
• Identification of the lydiamycin biosynthetic gene cluster in a plant pathogen guides structural revision and identification of molecular target AI翻译
  作者：Ford, Jonathan J.; Aberturas, Javier Santos -; Hems, Edward S.; Sallmen, Joseph W.; Bogeholz, Lena A. K.; Polturak, Guy; Osbourn, Anne; Wright, Joseph A.; V. Rodnina, Marina; Vereecke, Danny; Francis, Isolde M.; Truman, Andrew W.
  作者单位：Hebrew University of Jerusalem; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; University of East Anglia; HOWEST University of Applied Sciences; California State University System; California State University Bakersfield
  摘要：The natural products actinonin and matlystatin feature an N-hydroxy-2-pentyl-succinamyl (HPS) chemophore that facilitates metal chelation and confers their metalloproteinase inhibitory activity. Actinonin is the most potent natural inhibitor of peptide deformylase (PDF) and exerts antimicrobial and herbicidal bioactivity by disrupting protein synthesis. Here, we used a genomics-led approach to identify candidate biosynthetic gene clusters (BGCs) hypothesized to produce HPS-containing natural p...
• Click-constructed modular signal aptamer chimeras enable receptor-independent degradation of membrane proteins AI翻译
  作者：Xie, Wanlin; Sun, Weidi; Li, Qin; Dang, Yang; Ma, Lele; Liu, Yuan; Zhang, Hui; Qu, Fengli; Tan, Weihong
  作者单位：Tianjin University; Zhejiang Cancer Hospital; Chinese Academy of Sciences; Hangzhou Institute of Medicine, CAS
  摘要：Cell-membrane proteins are critical mediators of signal transduction, playing essential roles in disease occurrence and progression. The emerging LYTACs (Lysosome-targeting chimeras) technology combines drug-targeting strategies with lysosomal degradation, providing a novel approach to drug development and offering new possibilities for disease therapy. However, the clinical applicability of current LYTAC degraders is limited by the variable expression of lysosome-targeting receptors (LTRs) in...