2025

最新文章

• Make forensic case reports required legal and scientific documents AI翻译
  作者：Higley, Leon; Carter, David O.; Elowsky, Christian; Haskell, Christine; Haskell, Neal; Obanfunwa, John; Reinhard, Karl; Roe, Amanda; Schoenly, Ken; Simmons, Tal; Wells, Jeffrey
  作者单位：University of Nebraska System; University of Nebraska Lincoln; Chaminade University Honolulu; University of Nebraska System; University of Nebraska Lincoln; California State University System; California State University Stanislaus; Virginia Commonwealth University; State University System of Florida; Florida International University; State University System of Florida; Florida International University
• ATF6 enables pathogen infection in ticks by inducing stomatin and altering cholesterol dynamics AI翻译
  作者：Vosbigian, Kaylee A.; Wright, Sarah J.; Steiert, Brianna P.; Rosche, Kristin L.; Fisk, Elis A.; Ramirez-Zepp, Elisabeth; Park, Jason M.; Shelden, Eric A.; Shaw, Dana K.
  作者单位：Washington State University; Washington State University; University of Wisconsin System; University of Wisconsin Madison
  摘要：How tick-borne pathogens interact with their hosts has been primarily studied in vertebrates where disease is observed. Comparatively less is known about pathogen interactions within the tick. Here, we report that Ixodes scapularis ticks infected with either Anaplasma phagocytophilum (causative agent of anaplasmosis) or Borrelia burgdorferi (causative agent of Lyme disease) show activation of the ATF6 branch of the unfolded protein response (UPR). Disabling ATF6 functionally restricts pathogen...
• Unbalanced social-ecological acceleration led to state formation failure in early medieval Poland (vol 122, e2409056122, 2025) AI翻译
  作者：Izdebski, Adam; Czerwinski, Sambor; Jankowiak, Marek; Danielewski, Marcin; Fiolna, Sabina; Gromig, Raphael; Guzowski, Piotr; Haghipour, Negar; Hajdas, Irka; Kolaczek, Piotr; Lamentowicz, Mariusz; Marcisz, Katarzyna; Niebieszczanski, Jakub; Sankiewicz, Pawel; Wagner, Bernd
• Preacclimatization and base excess rather than deficit? AI翻译
  作者：Kleinsasser, Axel; Burtscher, Martin
  作者单位：Medical University of Innsbruck; University of Innsbruck
• Transglutaminase 2-mediated glutamine deamidation enhances p21 stability during senescence AI翻译
  作者：Liao, Yi-Wen; Hsieh, Hsi-Hsien; Yeh, Jin-Wei; Wang, Hsin-Chiao; Huang, Shang-Yi; Wang, Pei-Yu; Lin, Jing-Jer
  作者单位：National Taiwan University; National Taiwan University; National Taiwan University; National Taiwan University Hospital
  摘要：The limited doubling capacity of human cells, known as replicative senescence or cellular senescence, is a major factor in cellular aging. This process is triggered by telomere proliferation. p53, a transcriptional regulator, responds to DNA damage by increasing the expression of the cyclin- dependent kinase inhibitor p21. p21 then arrests cells at specific stages of the cell cycle. Additionally, p53 upregulates serpinB2 (also known as plasminogen activator inhibitor- 2, PAI- 2), which stabili...
• The great phage escape: Activating and escaping lactococcal antiphage systems AI翻译
  作者：Mosterd, Cas; Grafakou, Andriana; Charneco, Guillermo Ortiz; de Waal, Paul P.; van Rijswijck, Irma M. H.; van Peij, Noel N. M. E.; Pechoux, Christine; Kulakauskas, Saulius; Cambillau, Christian; Mahony, Jennifer; van Sinderen, Douwe
  作者单位：University College Cork; University College Cork; AgroParisTech; INRAE; Universite Paris Saclay; Universite Paris Saclay; INRAE; AgroParisTech; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB)
  摘要：In recent years, the number of newly discovered systems that bacteria use to combat bacteriophages is increasing at an impressive rate. To obtain mechanistic insights into several antiphage systems identified in previous studies, we isolated 66 phage escape mutants which had become insensitive to 13 distinct, plasmid- encoded lactococcal phage mutants identified a total of 15 mutated genes. Six of the encoded proteins appear to activate specific antiphage systems. Furthermore, AbiA escape muta...
• Biparental inheritance of germline- specific chromosomes in the sea lamprey and their roles in oocytes AI翻译
  作者：Timoshevskiy, Vladimir A.; Timoshevskaya, Nataliya; Eskut, Kaan I.; Rajandran, Kasturi; Smith, Jeramiah J.
  作者单位：University of Kentucky; University of Kentucky
  摘要：Many eukaryotic species undergo programmed elimination of specific chromosomes during embryogenesis, typically retaining these chromosomes only in their germ cells. In some species, programmatic elimination of GRCs, or sex chromosomes, also occurs in a sex-specific manner, with specific chromosomes being transmitted or eliminated by only one sex. As such, these chromosomes provide a unique perspective on the evolution of gene functions that are advantageous to the germline and genetic tradeoff...
• A skin-interfaced wireless wearable device and data analytics approach for sleep-stage and disorder detection AI翻译
  作者：Du, Yayun; Gu, Jianyu; Duan, Shiyuan; Trueb, Jacob; Tzavelis, Andreas; Shin, Hee-Sup; Arafa, Hany; Li, Xiuyuan; Huang, Yonggang; Carr, Andrew N.; Davies, Charles R.; Rogers, John A.
  作者单位：Northwestern University; Northwestern University; Northwestern University; Feinberg School of Medicine; Northwestern University; Procter & Gamble; Northwestern University; Northwestern University; Northwestern University
  摘要：Accurate identification of sleep stages and disorders is crucial for maintaining health, preventing chronic conditions, and improving diagnosis and treatment. Direct respiratory measurements, as key biomarkers, are missing in traditional wrist-or finger-worn wearables, which thus limit their precision in detection of sleep stages and sleep disorders. By contrast, this work introduces a simple, multimodal, skin-integrated, energy-efficient mechanoacoustic sensor capable of synchronized cardiac ...
• Natural dispersal is better than translocation for reducing risks of inbreeding depression in eastern black rhinoceros (Diceros bicornis michaeli) AI翻译
  作者：Mellya, Ronald. V. K.; Hopcraft, J. Grant C.; Mwakilema, William; Eblate, Ernest M.; Mduma, Simon; Mnaya, Bakari; Chuma, Idrissa S.; Macha, Emmanuel S.; Wambura, Dickson; Fyumagwa, Robert D.; Kilbride, Elizabeth; Ijaz, Umer Z.; Mable, Barbara K.; Khan, Anubhab
  作者单位：University of Glasgow; University of Glasgow; Indian Institute of Science (IISC) - Bangalore
  摘要：Due to increasing anthropogenic impacts, many species survive only in small and isolated populations. Active conservation management to reduce extinction risk includes increasing habitat connectivity, translocations from captive populations, or intensive surveillance of highly protected closed populations. Advances in sequencing technology mean that it is now possible to consider the genomic impacts of such strategies, as a proxy for variation in individual fitness. Using whole genome sequence...
• Creb5 controls its own expression and directly induces the joint interzone regulatory program AI翻译
  作者：Zhang, Cheng- Hai; Shahini, Aref; Cook, Laura E.; Mistry, Meeta; Kim, Jongkil; Wick, Heather; Pennacchio, Len A.; Lassar, Andrew B.
  作者单位：Harvard University; Harvard Medical School; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Harvard University; Harvard T.H. Chan School of Public Health
  摘要：Prior studies have indicated that the transcription factor Creb5 is expressed in the joint interzone, which contains the progenitors for all synovial joint tissues in both mouse and human embryos. In the absence of Creb5 function, most synovial joint interzones fail to form and the cartilage templates in the long bones remain fused. This earlier work did not clarify whether Creb5 initiates a cascade of signaling molecules, such as growth and differentiation factor 5 (Gdf5) and Wnt- family memb...