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作者：Schoknecht, Karl; Baeza-Lehnert, Felipe; Hirrlinger, Johannes; Dreier, Jens P.; Eilers, Jens
作者单位：Leipzig University; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin
摘要：Spreading depolarizations (SDs) have been identified in various brain pathologies. SDs increase the cerebral energy demand and, concomitantly, oxygen consumption, which indicates enhanced synthesis of adenosine triphosphate (ATP) by oxidative phosphorylation. Therefore, SDs are considered particularly detrimental during reduced supply of oxygen and glucose. However, measurements of intracellular neuronal ATP ([ATP]i), ultimately reporting the balance of ATP synthesis and consumption during SDs...
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作者：Chang, Ni-Chen; Wells, Jonathan N.; Wang, Andrew Y.; Schofield, Phillip; Huang, Yi-Chia; Truong, Vinh H.; Simoes-Costa, Marcos; Feschotte, Cedric
作者单位：Cornell University; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital
摘要：Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound of TE- derived sequences repurposed for organismal function. The process by which TEs become coopted remains obscure because most cases involve ancient, transpositionally inactive elements. Reports of active TEs serving beneficial functions are scarce and often contentious due to difficulties in manipulating repetitive sequences. Here, we show that recently active TEs in zebrafish encode products critical fo...
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作者：Zhang, Liyang; Yang, Jingxuan; Zhou, Zhijun; Ren, Yu; Chen, Bo; Tang, Anliu; Zhang, Kailiang; Li, Chuntao; Zhou, Hongshu; Fung, Kar - Ming; Xu, Chao; Kang, Chunsheng; Battiste, James D.; Bronze, Michael S.; Houchen, Courtney W.; Liu, Zhixiong; Dunn, Ian F.; Cavenee, Webster K.; Li, Min
作者单位：University of Oklahoma System; University of Oklahoma Health Sciences Center; University of Oklahoma System; University of Oklahoma Health Sciences Center; Central South University; Central South University; University of Oklahoma System; University of Oklahoma Health Sciences Center; University of Oklahoma System; University of Oklahoma Health Sciences Center; Tianjin Medical University; University of Oklahoma System; University of Oklahoma Health Sciences Center; University of California System; University of California San Diego
摘要：Glioblastoma (GBM) is the most aggressive form of brain cancer, with limited therapeutic options. While microglia contribute to GBM progression, the mechanisms by which they foster a protumorigenic immune environment remain poorly understood. We identify the zinc transporter Zrt-And Irt-Like Protein 4 (ZIP4) as a pivotal regulator of the GBM immune landscape. In orthotopic mouse models, ZIP4 drives tumor growth and behavioral changes. Mechanistically, ZIP4 modulates microglial plasticity throu...
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作者：Cheng, An-Po; Huang, Lihong; Oberkofler, Lorenz; Johnson, Nathan R.; Glodeanu, Adrian-Stefan; Stillman, Kyra; Weiberg, Arne
作者单位：University of Munich; Universidad Mayor; University of Hamburg; Guangzhou Medical University
摘要：Argonaute (AGO) proteins bind to small RNAs to induce RNA interference (RNAi), a conserved gene regulatory mechanism in animal, plant, and fungal kingdoms. Small RNAs of the fungal plant pathogen Botrytis cinerea were previously shown to translocate into plant cells and to bind to the host AGO, which induced cross-kingdom RNAi to promote infection. However, the role of pathogen AGOs during host infection stayed elusive. In this study, we revealed that members of fungal plant pathogen B. cinere...
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作者：Djermoun, Sarah; Rode, Daniel K. H.; Jimenez-Siebert, Eva; Netter, Niklas; Lesterlin, Christian; Drescher, Knut; Bigot, Sarah
作者单位：Centre National de la Recherche Scientifique (CNRS); Universite Claude Bernard Lyon 1; Institut National de la Sante et de la Recherche Medicale (Inserm); University of Basel
摘要：Plasmid conjugation is a contact-dependent horizontal gene transfer mechanism that significantly contributes to the dissemination of antibiotic resistance among bacteria. While the molecular mechanisms of conjugation have been extensively studied, our understanding of plasmid transfer dynamics within spatially structured bacterial communities and the influence of community architecture on plasmid dissemination remains limited. In this study, we use live-cell fluorescence microscopy to investig...
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作者：Makinen, Jussi; Ellis, Emilie E.; Antao, Laura H.; Davrinche, Andrea; Laine, Anna-Liisa; Saastamoinen, Marjo; Conenna, Irene; Hallforsa, Maria; Santangeli, Andrea; Kaarlejarvi, Elina; Heliolae, Janne; Huikkonen, Ida-Maria; Kuussaari, Mikko; Leinonen, Reima; Lehikoinen, Aleksi; Poyry, Juha; Suuronen, Anna; Salemaa, Maija; Tonteri, Tiina; Vuorio, Kristiina M.; Skjelbred, Birger; Jarvinen, Marko; Drakare, Stina; Carvalho, Laurence; Welk, Erik; Seidler, Gunnar; Vangansbeke, Pieter; Malis, Frantisek; Hedl, Radim; Auffret, Alistair G.; Plue, Jan; De Frenne, Pieter; Kalwij, Jesse M.; Vanhatalo, Jarno; Roslin, Tomas
作者单位：University of Helsinki; Finnish Environment Institute; University of Turku; Consejo Superior de Investigaciones Cientificas (CSIC); ATTITUS Educacao; University of Helsinki; Natural Resources Institute Finland (Luke); Norwegian Institute for Water Research (NIVA); Swedish University of Agricultural Sciences; Martin Luther University Halle Wittenberg; Ghent University; Technical University Zvolen; Czech Academy of Sciences; Institute of Botany of the Czech Academy of Sciences; Palacky University Olomouc; Swedish University of Agricultural Sciences; Swedish University of Agricultural Sciences; Helmholtz Association; Karlsruhe Institute of Technology; University of Johannesburg; University of Helsinki; University of Helsinki
摘要：Globally, rising temperatures are increasingly favoring warm-affiliated species. Although changes in community composition are typically measured by the mean temperature affinity of species (the community temperature index, CTI), they may be driven by different processes and accompanied by shifts in the diversity of temperature affinities and breadth of species thermal niches. To resolve the pathways to community warming in Finnish flora and fauna, we examined multidecadal changes in the domin...
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作者：Piacentino, Michael L.; Hutchins, Erica J.; Andrews, Cecelia J.; Bronner, Marianne E.
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作者：Wang, Yong; Wang, Junjie; Yao, Ge; Fan, Zheyong; Granato, Enzo; Kosterlitz, Michael; Ala-Nissila, Tapio; Car, Roberto; Sun, Jian
作者单位：Nanjing University; Nanjing University; Collaborative Innovation Center of Advanced Microstructures (CICAM); Princeton University; Bohai University; Instituto Nacional de Pesquisas Espaciais (INPE); Brown University; Aalto University; Loughborough University; Princeton University
摘要：The nature of solid phases and cross-over of order-disorder phase transitions from twodimensional (2D) layers to three-dimensional (3D) bulk in confined atomic systems remain largely unexplained. To this end, we consider noble gases and aluminum confined between graphene sheets at different pressures and temperatures. Using crystal structure search methods and molecular dynamics based on machine-learned potentials with quantum-mechanical accuracy, we identify structures of multilayer confined ...
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作者：Huang, Yung-Hsin; Belk, Julia A.; Zhang, Ruochi; Weiser, Natasha E.; Chiang, Zachary; Jones, Matthew G.; Mischel, Paul S.; Buenrostro, Jason D.; Chang, Howard Y.
作者单位：Stanford University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute
摘要：Spatial epigenomics and multiomics can provide fine-grained insights into cellular states but their widespread adoption is limited by the requirement for bespoke slides and capture chemistries for each data modality. Here, we present SPatial assay for Accessible chromatin, Cell lineages, and gene Expression with sequencing (SPACE-seq), a method that utilizes polyadenine-tailed epigenomic libraries to enable facile spatial multiomics using standard whole transcriptome reagents. Applying SPACE-s...
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作者：Kohler, Timothy A.; Bogaard, Amy; Ortman, Scott G.; Crema, Enrico R.; Chirikure, Shadreck; Cruz, Pablo; Green, Adam; Kerig, Tim; Mccoy, Mark D.; Munson, Jessica; Petrie, Cameron; Thompson, Amy E.; Birch, Jennifer; Quequezana, Gabriela Cervantes; Feinman, Gary M.; Fochesato, Mattia; Gronenborn, Detlef; Hamerow, Helena; Jin, Guiyun; Lawrence, Dan; Roscoe, Paul B.; Rosenstock, Eva; Erny, Grace K.; Kim, Habeom; Ohlrau, Rene; Hanson, J. W.; Navarro, Lane Fargher; Pailes, Matthew
作者单位：Washington State University; The Santa Fe Institute; University of Oxford; University of Colorado System; University of Colorado Boulder; University of Cambridge; University of York - UK; University of York - UK; University of Kiel; Leipzig University; State University System of Florida; Florida State University; University of Texas System; University of Texas Austin; University System of Georgia; University of Georgia; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Field Museum of Natural History (Chicago); Bocconi University; Johannes Gutenberg University of Mainz; Shandong University; Durham University; University of Maine System; University of Maine Orono; University of Maine System; University of Maine Orono; University of Bonn; University of California System; University of California Berkeley; University of Oxford; University System of Ohio; Ohio State University; University of Oklahoma System; University of Oklahoma - Norman
摘要：Defining wealth broadly to include wealth in people, relational connections, and material possessions, we examine the prehistory of wealth inequality at the level of the residential units using the consistent proxy of Gini coefficients calculated across areas of contemporaneous residential units. In a sample of >1,100 sites and > 47,000 residential units spanning >10,000 y, persistent wealth inequality typically lags the onset of plant cultivation by more than a millennium. It accompanies land...
