-
作者：Immorlano, Francesco; Eyring, Veronika; de Gouville, Thomas le Monnier; Accarino, Gabriele; Elia, Donatello; Mandt, Stephan; Aloisio, Giovanni; Gentine, Pierre
作者单位：Centro Euro-Mediterraneo sui Cambiamenti Climatici (CMCC); University of California System; University of California Irvine; Helmholtz Association; German Aerospace Centre (DLR); University of Bremen; Columbia University; Institut Polytechnique de Paris; Ecole Polytechnique; University of Salento
摘要：Precise and reliable climate projections are required for climate adaptation and mitigation, but Earth system models still exhibit great uncertainties. Several approaches have been developed to reduce the spread of climate projections and feedbacks, yet those methods cannot capture the nonlinear complexity inherent in the climate system. Using a Transfer Learning approach, we show that Machine Learning can be used to optimally leverage and merge the knowledge gained from global temperature map...
-
作者：Kharlamova, Maria A.; Kushwah, Manish S.; Jachowski, Tobias J.; Subramaniam, Sivaraman; Schiff, Viktor; Stewart, A. Francis; Kukura, Philipp; Schaeffer, Erik
作者单位：Eberhard Karls University of Tubingen; University of Oxford; Technische Universitat Dresden; University of New South Wales Sydney; Shandong University
摘要：Genome maintenance and stability rely on the repair of DNA double-strand breaks. Breaks can be repaired via the single-strand-annealing pathway mediated by the protein RAD52. RAD52 oligomerizes to rings that are thought to promote annealing. However, rings have only been observed at micromolar concentrations at which annealing activity is impaired. Thus, it is unclear which oligomeric form is responsible for annealing. We combined single-molecule mass photometry with biochemical assays to dete...
-
作者：Carpenter, Stephen R.
作者单位：University of Wisconsin System; University of Wisconsin Madison
-
作者：Esposito, Edward P.; Rios, Hector Manuel Lopez; de la Cruz, Monica Olvera; Jaeger, Heinrich M.
作者单位：University of Chicago; University of Chicago; Northwestern University; Northwestern University; Northwestern University; Northwestern University
摘要：Magnetically responsive, mechanically flexible microstructures are desirable for applications ranging from smart sensors to remote-controlled actuation for surgery or robotics. Embedding magnetic nanoparticles into a thin matrix of elastic material enables high flexibility while exploiting the magnetic response of the individual particles. However, in the ultrathin limit of such nanocomposite materials, the particles become too small to sustain a permanent dipole moment. This implies that now ...
-
作者：Li, Fengwei; Zhang, Mengmeng; Liu, Chao; Cheng, Jie; Yang, Yawen; Peng, Xiangda; Li, Zhifeng; Cai, Wenfeng; Yu, Haipeng; Wu, Junjie; Guo, Yuyu; Geng, Hongkun; Fa, Yun; Zhang, Youming; Wu, Dalei; Yin, Yizhen
作者单位：Shandong University; Chinese Academy of Sciences; Qingdao Institute of Bioenergy & Bioprocess Technology, CAS
摘要：Macrocyclic peptides have emerged as promising drug candidates, filling the gap between small molecules and large biomolecules in drug discovery. The antiapoptotic protein myeloid cell leukemia 1 (MCL1) is crucial for numerous cancers, yet it presents challenges for selective targeting by traditional inhibitors. In this study, we identified a macrocyclic peptide, 5L1, that strongly binds to MCL1, with a dissociation constant (KD) of 7.1 nM. This peptide shows the potential to specifically inhi...
-
作者：Sidik, Saima
-
作者：Colen, Jonathan; Han, Ming; Zhang, Rui; Redford, Steven A.; Lemma, Linnea M.; Morgan, Link; Ruijgrok, Paul, V; Adkins, Raymond; Bryant, Zev; Dogic, Zvonimir; Gardel, Margaret L.; de Pablo, Juan J.; Vitelli, Vincenzo
-
作者：Wang, Lin; Zhang, Haonan; Jia, Qi; Li, Wenyan; Yang, Chenguang; Ma, Lijuan; Li, Ming; Lu, Ying; Zhu, Hongtao; Zhu, Ping
作者单位：Chinese Academy of Sciences; Institute of Biophysics, CAS; Chinese Academy of Sciences; Institute of Physics, CAS; Chinese Academy of Sciences; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：NuA4 is the only essential acetyltransferase in yeast that can catalyze the acetylation the histones H2A, H2A.Z, and H4, thereby affecting gene transcription. However, the acetylation process of NuA4, such as how NuA4 acetylates H4 and H2A.Z differently, remains largely elusive. Here, using cryoelectron microscopy (cryo-EM) single particle analysis, we present seven cryo-EM structures of piccolo NuA4 (pNuA4) in complex with wild-type H2A.Z or H2A.Z-mutant-containing nucleosomes in the absence ...
-
作者：Chae, Rebecca L.; Siddiqui, Rafay; Xu, Yan
-
作者：Ma, Xixian; Lu, Yan; Stoneking, Mark; Xu, Shuhua
作者单位：Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Institute of Nutrition & Health, CAS; Shenzhen Bay Laboratory; Fudan University; Fudan University; Max Planck Society; VetAgro Sup; Centre National de la Recherche Scientifique (CNRS); Fudan University
摘要：Positive selection at the 2q21.3 enhancer region for lactase gene (LCT) expression in Europeans and Africans has long been attributed to selection for lactase persistence (LP), the capacity of adults to digest lactose in milk, presumably because of the benefits associated with milk consumption. While considered a classic example of gene-culture coevolution, recently doubts have been raised about the link between selection at 2q21.3 and LP. Analysis of additional populations could shed further ...
