2025

最新文章

• Crucial role of the cGAS N terminus in mediating flowable and functional cGAS-DNA condensate formation via DNA interactions AI翻译
  作者：Jiang, Zhelin; Shi, Fan; Li, Juan; Liu, Rui; Zhou, Jinhua; Zhong, Zhensheng; Shi, Chaowei; Ma, Mingming; Xiang, Shengqi; Gao, Daxing
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Anhui Medical University; Anhui Medical University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS
  摘要：The DNA- sensing protein cGAS plays a pivotal role in the innate immune response and pathogenesis of various diseases. DNA triggers liquid-liquid phase separation (LLPS) and enhances the enzymatic activity of cGAS. However, the regulatory mechanisms of the disordered N terminus remain unclear. Here, we showed that cGASNterm, the N- terminal intrinsic disordered region (IDR) of cGAS, modulates the material properties, specifically the flowability, of the condensed phase of cGAS and is required ...
• Constraining the history of water and climate on Mars through light element stable isotope analysis of volatiles in returned martian samples AI翻译
  作者：Grady, Monica M.
  作者单位：Open University - UK
  摘要：Much has been learned about Mars through data returned from space missions and analyses of martian meteorites. There are, however, many questions still outstanding which cannot currently be answered-including the issue of whether there is, or was, life on Mars. The return of a cache of samples-including of the atmosphere-from separate locations in Jezero Crater and with differing petrogeneses will provide the international community with the opportunity to explore part of the evolutionary hist...
• The cGAS-STING, p38 MAPK, and p53 pathways link genome instability to accelerated cellular senescence in ATM- deficient murine lung fibroblasts AI翻译
  作者：Haj, Majd; Frey, Yann; Levon, Amit; Maliah, Avishai; Ben-Yishay, Tal; Slutsky, Rachel; Smoom, Riham; Tzfati, Yehuda; Ben-David, Uri; Levy, Carmit; Elkon, Ran; Ziv, Yael; Shiloh, Yosef
  作者单位：Tel Aviv University; Hebrew University of Jerusalem
  摘要：Ataxia-telangiectasia (A- T) is a pleiotropic genome instability syndrome resulting from the loss of the homeostatic protein kinase ATM. The complex phenotype of A- T includes progressive cerebellar degeneration, immunodeficiency, gonadal atrophy, interstitial lung disease, cancer predisposition, endocrine abnormalities, chromosomal instability, radiosensitivity, and segmental premature aging. Cultured skin fibroblasts from A- T patients exhibit premature senescence, highlighting the associati...
• Aberrant neuronal hyperactivation causes an age- dependent behavioral decline in Caenorhabditis elegans AI翻译
  作者：Aleogho, Binta Maria; Mohri, Mizuho; Jang, Moon Sun; Tsukada, Sachio; Al-Hebri, Yana; Matsuyama, Hironori J.; Tsukada, Yuki; Mori, Ikue; Noma, Kentaro
  作者单位：Keio University; Chinese Institute for Brain Research, Beijing
  摘要：Age- dependent sensory impairment, memory loss, and cognitive decline are generally attributed to neuron loss, synaptic dysfunction, and decreased neuronal activities over time. Concurrently, increased neuronal activity is reported in humans and other organisms during aging. However, it is unclear whether neuronal hyperactivity is the cause of cognitive impairment or a compensatory mechanism of circuit dysfunction. The roundworm Caenorhabditis elegans exhibits age- dependent declines in an ass...
• Deep conservation complemented by novelty and innovation in the insect eye ground plan AI翻译
  作者：Gao, Ke; Donati, Antoine; Ainsworth, Julia; Wu, Di; Terner, Eleanor R.; Perry, Michael W.
  作者单位：University of California System; University of California San Diego
  摘要：A spectacular diversity of forms and features allow species to thrive in different environments, yet some structures remain relatively unchanged. Insect compound eyes are easily recognizable despite dramatic differences in visual abilities across species. It is unknown whether distant insect species use similar or different mechanisms to pattern their eyes or what types of genetic changes produce diversity of form and function. We find that flies, mosquitos, butterflies, moths, beetles, wasps,...
• The effect of job loss on risky financial decision-making AI翻译
  作者：Hirshman, Samuel D.; Sussman, Abigail B.; Vazquez-Hernandez, Carlos; O'Leary, Daniel; Trueblood, Jennifer S.
  作者单位：Norwegian School of Economics (NHH); University of Chicago; University of Sydney; Indiana University System; Indiana University Bloomington
  摘要：Job loss is a common and disruptive life event. It is known to have numerous longterm negative effects on financial, health, and social outcomes. While the negative effects of becoming unemployed on health and well-being are well understood, the influence of job loss on financial decisions has received little attention. Across a largescale survey (N = 37,854), spending data from a bank (N = 404,470), and two online experiments (total N = 1,403), we find that job loss increases financial risk t...
• Reconciling heterogeneous dengue virus infection risk estimates from different study designs AI翻译
  作者：Huang, Angkana T.; Buddhari, Darunee; Kaewhiran, Surachai; Iamsirithaworn, Sopon; Khampaen, Direk; Farmer, Aaron; Fernandez, Stefan; Thomas, Stephen J.; Rodriguez-Barraquer, Isabel; Hunsawong, Taweewun; Srikiatkhachorn, Anon; dos Santos, Gabriel Ribeiro; O'Driscoll, Megan; Hamins-Puertolas, Marco; Endy, Timothy; Rothman, Alan L.; Cummings, Derek A. T.; Anderson, Kathryn; Salje, Henrik
  作者单位：University of Cambridge; United States Department of Defense; United States Army; Walter Reed Army Institute of Research (WRAIR); Armed Forces Research Institute of Medical Science (AFRIMS); State University System of Florida; University of Florida; Ministry of Public Health - Thailand; State University of New York (SUNY) System; SUNY Upstate Medical University; University of California System; University of California San Francisco; University of Rhode Island
  摘要：Uncovering rates at which susceptible individuals become infected with a pathogen, i.e., the force of infection (FOI), is essential for assessing transmission risk and reconstructing distribution of immunity in a population. For dengue, reconstructing exposure and susceptibility statuses from the measured FOI is of particular significance as prior exposure is a strong risk factor for severe disease. FOI can be measured via many study designs. Longitudinal serology is considered gold standard m...
• Integrating climate and physical constraints into assessments of net capture from direct air capture facilities AI翻译
  作者：Shorey, Patrick; Abdulla, Ahmed
  作者单位：Carleton University; Natural Resources Canada; CanmetENERGY
  摘要：Limiting climate change to targets enshrined in the Paris Agreement will require both deep decarbonization of the energy system and the deployment of carbon dioxide removal at potentially large scale (gigatons of annual removal). Nations are pursuing direct air capture to compensate for inertia in the expansion of low-carbon energy systems, decarbonize hard-to-abate sectors, and address legacy emissions. Global assessments of this technology have failed to integrate factors that affect net cap...
• The changing relationship between racial identity and skin color in Brazil AI翻译
  作者：Freeman, Nicholas C.; Telles, Edward E.; Goldberg, Rachel E.; Alba, Richard
  作者单位：University of California System; University of California Irvine
  摘要：In recent years, Brazil's non- White (Brown and Black) population became a numerical majority for the first time since the 19th century. Although we know this change was mostly due to racial reclassification, we do not know how such changes are related to skin color, the primary marker of race in Brazil. Using data from six Latin American Public Opinion Project (LAPOP), or America's Barometer, surveys from 2010 to 2023, we examine how changes in racial self- identification (White, Brown, or Bl...
• FGF21 acting on the noradrenergic nervous system protects against influenza virus infection AI翻译
  作者：Fan, Wei; Zhang, Yuan; Gautron, Laurent; Thomas, David G.; Delgado, Heather W. Stout -; Schenck, Edward J.; Gwatiringa, Tadiwanashe; Rajagopalan, Kartik N.; Mangelsdorf, David J.; Kliewer, Steven A.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Cornell University; Weill Cornell Medicine; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
  摘要：The hormone fibroblast growth factor 21 (FGF21) is induced in murine liver in response to both bacterial and viral infection. In this report, we show that FGF21 is induced by infection with influenza virus in both humans and mice. Mice lacking FGF21 had decreased food intake, body weight, and body temperature compared to wild-type mice following influenza virus inoculation, indicating reduced tolerance to the infection. Conversely, pharmacologic administration of FGF21 after viral infection pr...