-
作者：Langlois-Lemay, Laurence; D'Amours, Damien
作者单位：University of Ottawa
摘要：The ability of cells to overcome cell cycle arrest and adapt to the presence of unrepairable DNA damage is under the control of Polo-like kinases (PLKs) in eukaryotes. How DNA damage checkpoints are silenced or bypassed during the adaptation response is unknown, but the process requires enrichment of the Cdc5 PLK to microtubule organizing centers (MTOCs), such as the yeast centrosomes or spindle pole bodies (SPBs). Here, we found that SPBs play an active role as supramolecular organizing cente...
-
作者：Aksoy, Cevat Giray; Barrero, Jose Maria; Bloom, Nicholas; Davis, Steven J.; Dolls, Mathias; Zarate, Pablo
作者单位：European Bank of Reconstructon & Development; University of London; King's College London; University of London; King's College London; Instituto Tecnologico Autonomo de Mexico; Stanford University; Stanford University; Leibniz Association; Ifo Institut; Princeton University
摘要：Work from home (WFH) surged worldwide during the COVID-19 pandemic, then partially receded as the pandemic subsided. Using our Global Survey of Working Arrangements covering dozens of countries, we find that average WFH rates among college-educated employees stabilized after 2022. The average number of WFH days per week is steady at roughly 1 d per week globally from 2023 through early 2025. Cross-country variation persists: WFH is about twice as common in advanced English-speaking economies a...
-
作者：Dargis, Rokas; Pajak, Joshua; Ariyawansa, Pavan; Morais, Marc C.; Jardine, PaulJ.; Arya, Gaurav
作者单位：Duke University; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; Indiana University System; Indiana University Bloomington; University of Minnesota System; University of Minnesota Twin Cities
摘要：Certain viruses such as tailed bacteriophages and herpes simplex virus package double-stranded DNA into empty procapsids via powerful, ring-shaped molecular motors. High-resolution structures and force measurements on the DNA packaging motor of bacteriophage X29 revealed that its five ATPase subunits coordinate ATP hydrolysis with each other to maintain the proper cyclic sequence of DNA translocation steps about the ring. Here, we explore how the X29 motor regulates translocation by timing key...
-
作者：Chen, Jitao; Li, Shihan; Zhang, Shuang; Isson, Terry; Dahl, Tais W.; Planavsky, Noah J.; Zhang, Feifei; Wang, Xiang-dong; Shen, Shu-zhong; Montanez, Isabel P.
作者单位：Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Texas A&M University System; Texas A&M University College Station; University of Waikato; University of Copenhagen; Yale University; Nanjing University; Nanjing University; University of California System; University of California Davis; University of California System; University of California Davis
摘要：The Late Paleozoic Ice Age (similar to 340 to 260 Ma) occurred under peak atmospheric O-2 (1.2 to 1.7 PIAL, pre-industrial atmospheric levels) for Earth history and CO2 concentrations comparable to those of the preindustrial to that anticipated for our near future. The evolution of the marine redox landscape under these conditions remains largely unexplored, reflecting that oceanic anoxia has long been considered characteristic of carbon cycle perturbation during greenhouse times. Despite elev...
-
作者：Bahlburg, Dominik; Menze, Sebastian; Krafft, Bjorn A.; Lowther, Andy D.; Meyer, Bettina
作者单位：Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; Institute of Marine Research - Norway; Norwegian Polar Institute
摘要：Antarctic krill is a keystone species in the Antarctic marine ecosystem and the target of a growing fishery. Given the ecological importance of krill, concerns have been raised about potential negative impacts of fishing on the Southern Ocean ecosystem. Resource-efficient approaches to fisheries monitoring are particularly valuable in this context due to the high costs associated with data collection in Antarctica. In this study, we trained a segmentation model (U-Net) to extract dives of air-...
-
作者：McAvoy, Alex; Sehwag, Udari Madhushani; Hilbe, Christian; Chatterjee, Krishnendu; Barfuss, Wolfram; Su, Qi; Leonard, Naomi Ehrich; Plotkin, Joshua B.
作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Stanford University; Max Planck Society; Institute of Science & Technology - Austria; University of Bonn; University of Bonn; Shanghai Jiao Tong University; Princeton University; University of Pennsylvania; University of Pennsylvania
摘要：Multiagent learning is challenging when agents face mixed-motivation interactions, where conflicts of interest arise as agents independently try to optimize their respective outcomes. Recent advancements in evolutionary game theory have identified a class of zero-determinant strategies, which confer an agent with significant unilateral control over outcomes in repeated games. Building on these insights, we present a comprehensive generalization of zero-determinant strategies to stochastic game...
-
作者：Suter, Thomas; Friedman, Meyer J.; Tazearslan, Cagdas; Merkurjev, Daria; Ohgi, Kenny; Meluzzi, Dario; Rosenfeld, Michael G.; Suh, Yousin
作者单位：University of California System; University of California San Diego; Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Columbia University; NewYork-Presbyterian Hospital; NewYork-Presbyterian Hospital; Columbia University
摘要：Cellular senescence, a major contributor to aging and age-related pathologies, is characterized by irreversible proliferative arrest and a disease-linked, proinflammatory profile known as the Senescence Associated Secretory Phenotype (SASP). A critical unanswered question is whether these properties are regulated by specific enhancer subsets, potentially licensing strategies that selectively block deleterious SASP components. Here, we identify two functionally distinct and independently regula...
-
作者：Takata, Mamoru; Takahashi, Michihiko; Ishibashi, Tomoki; Tasaki, Eisuke; Rueppell, Olav; Vargo, Edward L.; Matsuura, Kenji
作者单位：Kyoto University; University of Alberta; Texas A&M University System; Texas A&M University College Station; National Institute of Advanced Industrial Science & Technology (AIST); RIKEN; Niigata University
摘要：The discovery of transgenerational epigenetic inheritance and the unraveling of its molecular mechanisms are currently solving previously puzzling challenges that Mendelian genetics based solely on DNA could not explain, leading to significant paradigm shifts across various fields of biology. There has been a long-standing controversy over the factors determining the caste fate of individuals in social insects. Increasing evidence supports heritable influences on division of labor. Here, we pr...
-
作者：Mostofa, Mohammad Golam; Sahu, Abira; Xu, Yuan; Basrai, Insiya; Doron, Lior; Lefrancois, Violet; Sharkey, Thomas D.
作者单位：United States Department of Energy (DOE); Michigan State University; Michigan State University; Michigan State University; State University of New York (SUNY) System; State University of New York (SUNY) College of Environmental Science & Forestry; SUNY Maritime College; University of Alabama System; University of Alabama Birmingham
摘要：Isoprene is the most abundant nonmethane biogenic hydrocarbon emitted by some plants, mostly trees. It plays critical roles in atmospheric chemistry by contributing to ozone and aerosol formation. Isoprene also benefits plants, particularly under stress, through its signaling roles. Legume crops like soybean were thought to have evolutionarily lost isoprene synthase (ISPS) and are typically considered nonemitters. Here, we report that damage to soybean leaves by wounding or burning triggered a...
-
作者：Aydin, Alhun; Keski-Rahkonen, Joonas; Graf, Anton M.; Yuan, Shaobing; Ouyang, Xiao-Yu; Muestecaplioglu, Ozguer E.; Heller, Eric J.
作者单位：Sabanci University; Harvard University; Harvard University; Princeton University; California Institute of Technology; Koc University
摘要：The quantum acoustic framework has recently emerged as a nonperturbative, coherent approach to electron-lattice interactions, uncovering rich physics often obscured by perturbative methods with incoherent scattering events. Here, we model the strongly coupled dynamics of electrons and acoustic lattice vibrations within this framework, representing lattice vibrations as coherent states and electrons as quantum wave packets, in a manner distinctively different from tight-binding or discrete hopp...
