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作者：Pitzen, Samuel P.; Rudenick, Amber N.; Qiu, Yinjie; Zhang, Weijie; Munro, Sarah A.; Mccluskey, Braedan M.; Forster, Colleen; Bergom, Hannah E.; Ali, Atef; Boytim, Ella; Lafin, John T.; Linder, Simon; Ismail, Mazlina; Devlies, Wout; Sessions, Conner J.; Claessens, Frank; Joniau, Steven; Attard, Gerhardt; Zwart, Wilbert; Nelson, Peter S.; Corey, Eva; Wang, Yuzhuo; Lang, Joshua M.; Beltran, Himisha; Strand, Douglas; Antonarakis, Emmanuel S.; Hwang, Justin; Murugan, Paari; Huang, R. Stephanie; Dehm, Scott M.
作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Texas System; University of Texas Southwestern Medical Center; Netherlands Cancer Institute; University of London; University College London; KU Leuven; University Hospital Leuven; KU Leuven; University of Washington; University of Washington Seattle; KU Leuven; University of London; University College London; University College London Hospitals NHS Foundation Trust; Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle; Fred Hutchinson Cancer Center; University of British Columbia; British Columbia Cancer Agency; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; University of Minnesota System; University of Minnesota Twin Cities
摘要：Inhibiting the androgen receptor (AR) is effective for treatment of advanced prostate cancers because of their AR- dependent luminal epithelial cell identity. Tumors progress during therapy to castration- resistant prostate cancer (CRPC) by restoring AR signaling and maintaining luminal identity or by converting through lineage plasticity to a neuroendocrine (NE) identity or double- negative CRPC (DNPC) lacking luminal or NE identities. Here, we show that DNPC cells express genes defining basa...
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作者：Singh, Kirat; Lobell, David B.; Azevedo, Ines M. L.
作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Universidade Nova de Lisboa
摘要：Air pollution from coal electricity generation is a major driver of poor air quality in India and its effects on human health have been extensively studied. Despite considerable evidence that the same pollution also reduces crop productivity, we lack similar quantitative assessments of coal electricity's crop damages. Here, we estimate rice and wheat crop losses from coal generation's nitrogen dioxide (NO2) emissions using a regression model that combines station-level electricity generation a...
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作者：Takaki, Ryota; Thirumalai, D.
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作者：Gallego, Ruth Perez; von Meijenfeldt, F. A. Bastiaan; Bale, Nicole J.; Damste, Jaap S. Sinninghe; Villanueva, Laura
作者单位：Utrecht University; Royal Netherlands Institute for Sea Research (NIOZ); Utrecht University; Utrecht University
摘要：Heterocytes, specialized cells for nitrogen fixation in cyanobacteria, are surrounded by heterocyte glycolipids (HGs), which contribute to protection of the nitrogenase enzyme from oxygen. Diverse HGs preserve in the sediment and have been widely used as evidence of past nitrogen fixation, and structural variation has been suggested to preserve taxonomic information and reflect paleoenvironmental conditions. Here, by comprehensive HG identification and screening of HG biosynthetic gene cluster...
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作者：Lenzen, Benjamin; Roesch, Florian; Legen, Julia; Ruwe, Hannes; Kachariya, Nitin; Sattler, Michael; Small, Ian; Schmitz- Linneweber, Christian
作者单位：Humboldt University of Berlin; Technical University of Munich; University of Western Australia
摘要：The chloroplast genome encodes key components of the photosynthetic light reac-tion machinery as well as the large subunit of the enzyme central for carbon fixation, Ribulose- 1,5- bisphosphat- carboxylase/- oxygenase (RuBisCo). Its expression is predom-inantly regulated posttranscriptionally, with nuclear- encoded RNA- binding proteins (RBPs) playing a key role. Mutants of chloroplast gene expression factors often exhibit impaired chloroplast biogenesis, especially in cold conditions. Low tem...
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作者：Beman, J. M.
作者单位：University of California System; University of California Merced; University of California System; University of California Merced
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作者：Conwell, Colin; Graham, Daniel; Boccagno, Chelsea; Vessel, Edward A.
作者单位：Harvard University; Hobart & William Smith Colleges; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard T.H. Chan School of Public Health; City University of New York (CUNY) System; City College of New York (CUNY)
摘要：Looking at the world often involves not just seeing things, but feeling things. Modern feedforward machine vision systems that learn to perceive the world in the absence of active physiology, deliberative thought, or any form of feedback that resembles human affective experience offer tools to demystify the relationship between seeing and feeling, and to assess how much of visually evoked affective experiences may be a straightforward function of representation learning over natural image stat...
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作者：Meng, Fanhui; Xie, Jiarong; Sun, Jiachen; Xu, Cong; Zeng, Yutian; Wang, Xiangrong; Jia, Tao; Huang, Shuhong; Deng, Youjin; Hu, Yanqing
作者单位：Sun Yat Sen University; Beijing Normal University; Beijing Normal University; Sun Yat Sen University; Southern University of Science & Technology; Shenzhen University; Chongqing Normal University; Southwest University - China; Technical University of Munich; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Minjiang University; Southern University of Science & Technology
摘要：Social media is profoundly changing our society with its unprecedented spreading power. Due to the complexity of human behaviors and the diversity of massive messages, the information-spreading dynamics are complicated, and the reported mechanisms are different and even controversial. Based on data from mainstream social media platforms, including WeChat, Weibo, and Twitter, cumulatively encompassing a total of 7.45 billion users, we uncover a ubiquitous mechanism that the information- spreadi...
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作者：Sitko, Austen A.; Frank, Michelle M.; Romero, Gabriel E.; Hunt, Mackenzie; Goodrich, Lisa, V
作者单位：Harvard University; Harvard Medical School
摘要：The sense of hearing originates in the cochlea, which detects sounds across dynamic sensory environments. Like other peripheral organs, the cochlea is subjected to environmental insults, including loud, damage- inducing sounds. In response to internal and external stimuli, the central nervous system directly modulates cochlear function through olivocochlear neurons (OCNs), which are located in the brainstem and innervate the cochlear sensory epithelium. One population of OCNs, the lateral oliv...
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作者：Zhang, Yibi; Wang, Xiaodong; Gu, Yinmin; Liu, Tongfeng; Zhao, Xujie; Cheng, Shuwen; Duan, Liqiang; Huang, Chang; Wu, Songzhe; Gao, Shan
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; Suzhou Institute of Biomedical Engineering & Technology, CAS; Southeast University - China; Southeast University - China; Guizhou University; Nanjing University
摘要：Heterogeneous roles of complement C3 have been implicated in tumor metastasis and are highly context dependent. However, the underlying mechanisms linking C3 to tumor metastasis remain elusive in renal cell carcinoma (RCC). Here, we demonstrate that C3 of RCC cell- derived extracellular vesicles (EVs) contributes to metastasis via polarizing tumor- associated macrophages (TAMs) into the immunosuppressive phenotype and recruiting polymorphonuclear myeloid- derived suppressor cells (PMN- MDSCs)....
