2025

最新文章

• Profile of Sharon Y. Strauss AI翻译
  作者：Viegas, Jennifer
• Gibberellin- deactivating GA2OX enzymes act as a hub for auxin-gibberellin cross talk in Arabidopsis thaliana root growth regulation AI翻译
  作者：Kubalova, Monika; Griffiths, Jayne; Mueller, Karel; Levenets, Lev; Tylova, Edita; Tarkowska, Danuse; Jones, Alexander M.; Fendrych, Matyas
  作者单位：Czech Academy of Sciences; Institute of Experimental Botany of the Czech Academy of Sciences; Charles University Prague; University of Cambridge; Palacky University Olomouc; Czech Academy of Sciences; Institute of Experimental Botany of the Czech Academy of Sciences; Palacky University Olomouc
  摘要：Plant bodies are built from immobile cells, making the regulation of cell expansion essential for growth, development, and adaptation. In roots, cell elongation executes the movement of the root tips through the soil. This process is tightly controlled by numerous signaling pathways. Among these, gibberellin and auxin signaling stand out for their contrasting effects on root growth, interacting through complex cross talk at multiple regulatory levels. Here, we reveal the molecular basis of the...
• Global synthesis and regional insights for mainstreaming urban nature-based solutions AI翻译
  作者：McPhearson, Timon; Frantzeskaki, Niki; Ossola, Alessandro; Diep, Loan; Anderson, Pippin M. L.; Blatch, Timothy; Collier, Marcus J.; Cook, Elizabeth M.; Fatti, Christina Culwick; Grabowski, Zbigniew J.; Grimm, Nancy B.; Haase, Dagmar; Herreros-Cantis, Pablo; Kavonic, Jessica; Lin, Brenda B.; Meneses, Duvan H. Lopez; Matsler, A. Marissa; Moglia, Magnus; Morato, Jordi; O'Farrell, Patrick; Roy, Parama; Singh, Chandni; Wang, Jing; Zhou, Weiqi
  作者单位：The New School; Cary Institute of Ecosystem Studies; Stockholm University; Royal Swedish Academy of Sciences; Beijer Institute of Ecological Economics; Utrecht University; University of California System; University of California Davis; University of Melbourne; Macquarie University; University of Cape Town; Trinity College Dublin; Columbia University; University of Connecticut; University of Connecticut; Arizona State University; Arizona State University-Tempe; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); Basque Centre for Climate Change (BC3); Autonomous University of Barcelona; Commonwealth Scientific & Industrial Research Organisation (CSIRO); Universitat Politecnica de Catalunya; University System of Maryland; University of Maryland College Park; Swinburne University of Technology; Universitat Politecnica de Catalunya; University of the Western Cape; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Madras; Indian Institute for Human Settlements (IIHS); Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Nature-based solutions(NbS) have emerged as a key strategy for sustainably addressing multiple urban challenges, with rapidly increasing knowledge production requiring synthesis to better understand whether and how NbS work in different social, ecological, economic, or governance contexts. Insights in this Perspective are drawn from a thematic review of 61 NbS review articles supported by an expert assessment of NbS knowledge in seven global regions to examine key challenges, fill gaps in Glob...
• Amyloid-β modulates the phase separation and aggregation of α- synuclein AI翻译
  作者：Rontgen, Alexander; Toprakcioglu, Zenon; Morris, Owen M.; Vendruscolo, Michele
  作者单位：University of Cambridge
  摘要：The aggregation of amyloid-beta (A beta) and alpha- synuclein (alpha Syn) into insoluble proteinaceous deposits is a hallmark of Alzheimer's and Parkinson's diseases. Recent evidence suggests that these amyloidogenic proteins act in synergy, with their coaggregation frequently observed in these disorders. In this study, we investigate the interaction of A beta and alpha Syn using various biophysical tools. In particular, we explore the cocondensation of A beta with alpha Syn, elucidating the p...
• Predicting regime shifts and beyond AI翻译
  作者：Thygesen, Uffe Hogsbro
  作者单位：Technical University of Denmark
• Common inherited loss-of-function mutations in the innate sensor NOD2 contribute to exceptional immune response to cancer immunotherapy AI翻译
  作者：Barnet, Megan B.; L., Katherine J.; Masle, Etienne; Russell, Amanda; Burnett, Deborah L.; Chye, Adrian; Jara, Chris J.; Faulks, Megan; Mawson, Amanda; Peters, Timothy J.; Brink, Robert; Wright, Katherine; Allen, India; Junankar, Simon; Davis, Ian D.; Heller, Gillian; Khan, Zia; Bruce, Jeffrey; Yang, Cindy; Prokopec, Stephenie; Pugh, Trevor; Behren, Andreas; Hold, Georgina L.; Zhang, Fan; Cooper, Wendy A.; Gao, Bo; Nagrial, Adnan; Joshua, Anthony M.; John, Thomas; Peters, Geoffrey; Hui, Rina; Boyer, Michael; Blinman, Prunella L.; Kao, Steven C.; Cebon, Jonathan; Goodnow, Christopher C.
  作者单位：Garvan Institute of Medical Research; University of New South Wales Sydney; NSW Health; St Vincents Hospital Sydney; The Kinghorn Cancer Centre; University of Technology Sydney; University of New South Wales Sydney; University of New South Wales Sydney; Monash University; La Trobe University; Olivia Newton-John Cancer Research Institute; Eastern Health; University of Sydney; Roche Holding; Genentech; Roche Holding USA; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; La Trobe University; University of Melbourne; University of New South Wales Sydney; Western Sydney University; University of Sydney; NSW Health; Royal Prince Alfred Hospital; University of Sydney; NSW Health; Blacktown & Mount Druitt Hospital; University of Sydney; NSW Health; Westmead Hospital; Peter Maccallum Cancer Center; Chris O'Brien Lifehouse; Concord Repatriation General Hospital
  摘要：Lung cancers and melanomas have many somatically mutated self-proteins that would be expected to trigger an immune rejection response, yet therapeutic responses can only be induced in a subset of patients. Here, we investigated the possibility that inherited differences in immune tolerance checkpoints contribute to variability in outcomes. Whole genome sequencing revealed biallelic germline loss-of-function (LOF) mutations in the immune tolerance checkpoint gene, NOD2, in an exceptional immune...
• Cilia dynamics create a dynamic barrier to penetration of the periciliary layer in human airway epithelia AI翻译
  作者：Causa, Erika; Das, Debasish; Feriani, Luigi; Kotar, Jurij; Cicuta, Pietro
  作者单位：University of Cambridge; University of Strathclyde
  摘要：The ciliated epithelium of the human respiratory tract is covered by the airway surface liquid, a protective fluid consisting of two layers: the periciliary layer (PCL), where motile cilia reside and generate fluid flow, and an overlying mucus layer. The complex structure and stratified nature of the PCL complicate both the prediction and quantification of fluid flow at the scale of individual or small groups of cilia, making it difficult to connect microscopic flows to macroscopic clearance. ...
• Optimization of a sarbecovirus llama nanobody-antigen binding interface via a combined computational and phage display protein engineering approach AI翻译
  作者：Ramos, Kevin E.; Nandigrami, Prithviraj; Najafian, Ahmad; Lai, Jonathan R.; Fiser, Andras
  作者单位：Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva University
  摘要：Single-domain antibodies, such as variable heavy domain of heavy chain (VHH) domains from camelids, are an attractive platform for therapeutic purposes. VHHs have a smaller size than traditional antibodies, which harbors certain advantages such as tissue penetration or accessing epitopes that may be shielded by protein domains. However, the smaller size of VHHs typically involves a smaller binding site, which can limit the scope of related antigens they are able to bind and, in the specific ca...
• Glycogen supports glycolytic plasticity in neurons AI翻译
  作者：Singh, Milind; Wolfe, Aaron D.; Vishwanath, Anjali A.; Tsives, Anastasia; Gonzalez, Ian J.; Emerson, Sarah E.; Goodman, Richard; Colon-Ramos, Daniel
  作者单位：Yale University; Yale University; Yale University; Marine Biological Laboratory - Woods Hole; University of Puerto Rico; University of Puerto Rico Medical Sciences Campus
  摘要：Glycogen is the largest energy reserve in the brain, but the specific role of glycogen in supporting neuronal energy metabolism in vivo is not well understood. We established a system in Caenorhabditis elegans to dynamically probe glycolytic states in single cells of living animals via the use of the glycolytic sensor HYlight and determined that neurons can dynamically regulate glycolysis in response to activity or transient hypoxia. We performed an RNAi screen and identified that PYGL-1, an o...
• Regulation of Na/Ca exchange by cytoplasmic protons modifies intracellular calcium dynamics and the cardiac response to ischemia AI翻译
  作者：Zhang, Rui; Wu, Xiaokang; Kim, Seho; Kim, Brian; Xie, Catherine; Gonzalez, Devina; Norris, Raven; Chin, Nicholas; Li, Liang; John, Scott; Philipson, Kenneth D.; Ottolia, Michela; Goldhaber, Joshua I.
  作者单位：Cedars Sinai Medical Center; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Cedars Sinai Medical Center
  摘要：The cardiac sodium-calcium exchanger (NCX1) is a critical regulator of intracellular calcium (Ca) in cardiomyocytes. Although strongly regulated by pH, the role of NCX1 pH sensitivity in cardiac function and intracellular Ca regulation is not understood. We used CRISPR/Cas9 to produce a pH-resistant NCX1 mouse by replacing histidine 165 with alanine (H165A). H165A mice live into adulthood and are fertile. Comparative studies in isolated ventricular myocytes demonstrated that NCX1 current (I-NC...