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作者：Altshuler, Boris L.; Kravtsov, Vladimir E.; Scardicchio, Antonello; Sierant, Piotr; Vanoni, Carlo
作者单位：Columbia University; Abdus Salam International Centre for Theoretical Physics (ICTP); Istituto Nazionale di Fisica Nucleare (INFN); Barcelona Institute of Science & Technology; Universitat Politecnica de Catalunya; Institut de Ciencies Fotoniques (ICFO); International School for Advanced Studies (SISSA)
摘要：We discuss the dependence of the critical properties of the Anderson model on the dimension d in the language of /3-function and renormalization group recently introduced in Vanoni et al. [C. Vanoni et al., Proc. Natl. Acad. Sci. U.S.A. 121, e2401955121 (2024)] in the context of Anderson transition on random regular graphs. We show how in the delocalized region, including the transition point, the one-parameter scaling part of the /3-function for the fractal dimension D1 evolves smoothly from ...
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作者：Langlois, Jill
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作者：Stephens, Dylon R.; Fung, Ho Yee Joyce; Han, Yan; Liang, Jue; Chen, Zhe; Ready, Joseph; Collins, James J.
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute
摘要：Schistosomes are parasitic flatworms that infect more than 200 million people globally. However, there is a shortage of molecular tools that enable the discovery of potential drug targets within schistosomes. Thus, praziquantel has remained the frontline treatment for schistosomiasis despite known liabilities. Here, we have conducted a genome- wide study in Schistosoma mansoni using the human druggable genome as a bioinformatic template to identify essential genes within schistosomes bearing s...
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作者：Curtis, Samuel D.; Panda, Sambit; Li, Adam; Xu, Haoyin; Bai, Yuxin; Ogihara, Itsuki; O'Reilly, Eliza; Wang, Yuxuan; Dobbyn, Lisa; Popoli, Maria; Ptak, Janine; Nehme, Nadine; Silliman, Natalie; Tie, Jeanne; Gibbs, Peter; -Pham, Lan T. Ho; Tran, Bich N. H.; Tran, Thach S.; Nguyen, Tuan V.; Irajizad, Ehsan; Goggins, Michael; Wolfgang, Christopher L.; Wang, Tian-Li; Shih, Ie-Ming; Fader, Amanda; Lennon, Anne Marie; Hruban, Ralph H.; Bettegowda, Chetan; Gilbert, Lucy; Kinzler, Kenneth W.; Papadopoulos, Nickolas; Vogelstein, Bert; Vogelstein, Joshua T.; Douville, Christopher
作者单位：Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins University; Columbia University; Johns Hopkins University; Johns Hopkins University; Howard Hughes Medical Institute; Walter & Eliza Hall Institute; University of Melbourne; Peter Maccallum Cancer Center; University of Melbourne; Western Health; University of Technology Sydney; University of Technology Sydney; University of New South Wales Sydney; Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Johns Hopkins University; McGill University; Johns Hopkins University
摘要：AI is now a cornerstone of modern dataset analysis. In many real world applications, practitioners are concerned with controlling specific kinds of errors, rather than minimizing the overall number of errors. For example, biomedical screening assays may primarily be concerned with mitigating the number of false positives rather than false negatives. Quantifying uncertainty in AI-based predictions, and in particular those controlling specific kinds of errors, remains theoretically and practical...
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作者：Dang, Pengfei; Ciais, Philippe; Gao, Jiaxin; Zhu, Yunxiao; Xue, Jiquan; Qin, Xiaoliang; Ros, Gerard H.
作者单位：Northwest A&F University - China; Universite Paris Saclay; Wageningen University & Research
摘要：Carbon sequestration through plant biomass responses to global warming plays a vital role in mitigating climate change, but recent evidence suggests that this effect diminishes in the long term. To investigate the effect of warming duration on plant biomass responses, we analyzed a global dataset of 2,291 paired observations, revealing that warming increased overall aboveground plant biomass by 9.4% and belowground biomass by 2.6%. However, as the warming duration increased, the positive plant...
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作者：Kuroda, Junya; Puthalakath, Hamsa; Cragg, Mark S.; Kelly, Priscilla N.; Bouillet, Philippe; Huang, David C. S.; Kimura, Shinya; Ottmann, Oliver G.; Druker, Brian J.; Villunger, Andreas; Roberts, Andrew W.; Strasser, Andreas
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作者：Pyne, Stephen
作者单位：Arizona State University; Arizona State University-Tempe
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作者：Jiang, Xingyuan; Mortlock, Ryland D.; Pironon, Nathalie; Zhou, Jing; Hu, Ronghua; Liu, William; Acosta, Agustina; Shwayder, Tor A.; Hovnanian, Alain; Lifton, Richard P.; Choate, Keith A.
作者单位：Yale University; Yale University; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Henry Ford Health System; Henry Ford Hospital; Rockefeller University; Yale University
摘要：Genetic investigation in Mendelian skin disorders featuring generalized or localized skin scaling and redness, known as the ichthyoses, has revealed novel pathways relevant to epidermal integrity, barrier function, and desquamation. Here, we show that a recurrent de novo missense variant in EMP2 (epithelial membrane protein 2), which encodes a cell surface tetraspan protein in the growth- arrest specific 3 (GAS3)/peripheral myelin protein 22 (PMP22) family, is associated with a Mendelian skin ...
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作者：Uzoigwe, Chika Edward
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作者：Frank, Steven A.
作者单位：University of California System; University of California Irvine
摘要：Cancer is the origin of a novel tissue that attracts resources, spreads beyond boundaries, avoids normal controls, and escapes immunity. How does a novel tissue arise? The puzzle is that two seemingly different processes appear to be the primary driving force. On the one hand, overwhelming evidence links (epi)genetic driver mutations to the origin and progression of tumors. Common oncogenic mutations such as KRAS accelerate cell division, and common knockouts of tumor suppressors such as TP53 ...
