6期

最新文章

• Water-mediated hydrogen bonds and local side-chain interactions in the cooperative collapse and expansion of PNIPAM oligomers AI翻译
  作者：Chen, Wanlin; Gruebele, Martin; Havenith, Martina; Hebel, Kurt J.; Scaletti, Carla
  作者单位：Ruhr University Bochum; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS)
  摘要：Poly(N-isopropylacrylamide) (PNIPAM), a thermoresponsive homopolymer, is a well-established model for investigating coil-to-globule transitions. Here, we combine to elucidate the roles of intramolecular and PNIPAM-solvent hydrogen-bond (H-bond) patterns in the PNIPAM globule-coil equilibrium. Our analysis separates the driving forces for compaction into two contributions: the entropic gain from the loss of hydration water around hydrophobic patches and the enthalpic stabilization from water H-...
• Molecular tuning of DNA framework-programmed silicification cationic silica cluster attachment AI翻译
  作者：Jing, Xinxin; Wang, Haozhi; Huang, Jianxiang; Liu, Yingying; Li, Zimu; Chen, Jielin; Xu, Yiqun; Li, Lingyun; Lin, Yunxiao; Buratto, Damiano; Xia, Qinglin; Pan, Muchen; Wang, Yue; Li, Mingqiang; Zhou, Ruhong; Mann, Stephen; Fan, Chunhai; Liu, Xiaoguo
  作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Zhejiang University; Zhejiang University; Zhejiang University; Chinese Academy of Sciences; Shanghai Institute of Applied Physics, CAS; Shanghai Jiao Tong University; University of Bristol
  摘要：The organizational complexity of biominerals has long fascinated scientists seeking to understand biological programming and implement new developments in biomimetic materials chemistry. Nonclassical crystallization pathways have been observed and analyzed in typical crystalline biominerals, such as calcium phosphate, calcium carbonate, and ferric oxide, involving the controlled attachment and reconfiguration of nanoparticles and clusters on organic templates. However, the understanding of tem...
• Pleistocene demographic histories dominate contemporary genomic diversity in a continental radiation of Himalayan-Hengduan songbirds AI翻译
  作者：Liu, Yadan; Hung, Chih -Ming; He, Yunrui; Wu, Fei; Yan, Dao; Song, Gang; Dong, Feng
  作者单位：Southwest Forestry University - China; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; Institute of Zoology, CAS
  摘要：Genetic diversity, the fundamental substrate for evolutionary potential, is declining globally at unprecedented rates. Yet the mechanisms governing its distribution across species remain poorly understood, with competing hypotheses emphasizing either historical demography or contemporary ecological constraints. This debate limits our capacity to predict species' responses to environmental change. Here, based on systematic sampling and a unified analytical pipeline, we de novo assembled genomes...
• Metabolite control of enzyme activity links stress to biosynthetic regulation AI翻译
  作者：Van De Ven, Wilhelmina; Hur, Manhoi; Gomez-Mendez, Maria Fernanda; Guo, Jingzhe; Ke, Haiyan; Mahmood, Raisul Awal; Kim, Sunghwan; Sharkey, Thomas D.; Dehesh, Katayoon
  作者单位：University of California System; University of California Riverside; Kyungpook National University (KNU); Michigan State University
  摘要：Cells must continuously adjust metabolic output to maintain homeostasis under changing environmental conditions, yet the mechanisms that enable rapid and reversible control of pathway activity remain largely unknown. The methylerythritol phosphate (MEP) pathway, of bacterial origin and conserved in plastid-bearing eukaryotes, including plants and apicomplexan parasites, produces isoprenoid precursors essential for growth and stress adaptation. Here, we identify methylerythritol cyclodiphosphat...
• Neurotensin in the extended amygdala maintains wakefulness in novel environments AI翻译
  作者：Hung, Chi Jung; Ueda, Shuhei; Rahaman, Sheikh Mizanur; Yamamoto, Mikiyasu; Li, Jiahui; Fukatsu, Noriaki; Bito, Haruhiko; Yamaguchi, Hiroshi; Yamanaka, Akihiro; Takemoto-Kimura, Sayaka; Ono, Daisuke
  作者单位：Nagoya University; Nagoya University; Nagoya University; Nagoya University; Nagoya University; University of Tokyo; National Institutes of Natural Sciences (NINS) - Japan; National Institute for Physiological Sciences (NIPS); Chinese Institute for Brain Research, Beijing
  摘要：Animals remain awake in unfamiliar environments to assess potential safety threats, a process involving changes in neuronal activity within sleep-wake regulatory brain regions. However, the specific circuits and neurotransmitters involved remain poorly understood. Here, we show that neurotensin (NTS) peptides in corticotropin-releasing factor (CRF) neurons of the lateral part of the interstitial nucleus of the posterior limb of the anterior commissure (IPACL) play a key role in maintaining wak...
• Molecular assemblies and pharmacology of cerebellar GABAA receptors AI翻译
  作者：Sun, Chang; Jahncke, Jennifer N.; Wright, Kevin M.; Gouaux, Eric
  作者单位：Oregon Health & Science University; Oregon Health & Science University; Howard Hughes Medical Institute
  摘要：GABAA receptors (GABAARs) mediate fast inhibitory neurotransmission in the brain and are assembled from 19 subunit isoforms into multiple pentameric assemblies. Although alpha 1-containing GABAARs are broadly expressed and are pharmacologically important, the molecular diversity of native alpha 1-based assemblies in specific brain regions remains incompletely understood. Here, we use immunofluorescence, mass spectrometry, and cryogenic electron microscopy (cryo-EM) to characterize the spatial ...
• Early psychosocial deprivation alters the refinement of neural dynamics across adolescence AI翻译
  作者：Andujar, Marta; Liuzzi, Lucrezia; Pine, Daniel S.; Nelson III, Charles A.; Zeanah, Charles H.; Fox, Nathan A.; Averbeck, Bruno B.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH); National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH); Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Tulane University; University System of Maryland; University of Maryland College Park
  摘要：Adolescence is a crucial period for the refinement of neural circuits and cognitive skills. During this time, executive functions mature alongside pronounced structural changes in the brain, including reductions in synapse density. Computational models suggest that synaptic pruning enhances performance by stabilizing neural dynamics-deepening attractor basins and accelerating return to baseline after perturbation. Here, we tested these predictions using EEG data from the Bucharest Early Interv...
• Ultrasonic vocal communication of negative affective states in laboratory mice AI翻译
  作者：Inagaki, Hideaki; Ushida, Takahiro
  作者单位：Aichi Medical University
  摘要：Anxiety disorders are the most common mental disorders, resulting in substantial social and economic costs stemming from reduced productivity. Pharmacotherapy is the most widely used treatment for these disorders, and effective improvement requires a reliable animal model of human anxiety. Although communication in rats using ultrasonic vocalizations (USVs) has been reported as a biologically valid animal model of human anxiety, an equivalent model in mice has not yet been established. To iden...
• Structural basis of mpox virus A30/H2 subcomplex formation AI翻译
  作者：Jia, Xiaohua; Lin, Sheng; Yang, Fanli; You, Yu; Yang, Ruixi; Chen, Zimin; Guo, Liyan; Yang, Jing; Wang, Lingling; Yuan, Xin; Zhang, Xindan; Xu, Pengli; Tong, Qin; He, Bin; Cao, Yu; Li, Jian; Zhao, Qi; Lu, Guangwen
  作者单位：Sichuan University; Sichuan University; Sichuan University; Chengdu University; Chengdu University
  摘要：The continuous spread of mpox disease caused by mpox virus (MPXV) has posed great threat to global public health. The postattachment membrane fusion process of MPXV is mediated by a multimeric protein machinery, termed as entry-fusion complex (EFC). Among EFC components, A30 and H2 are the earliest identified interaction pair and play important roles in virus entry. Here, we determine the crystal structure of MPXV A30/H2 subcomplex via the tandem-fusion strategy, and show that A30 undergoes la...
• T cell receptors for antigen on intraepithelial cytolytic T lymphocytes in celiac disease engage enterocyte HLA-E and HLA-B AI翻译
  作者：Johnson, Justin E.; Agrawal, Kriti; Al-Lamki, Rafia S.; Zhang, Fengrui; Wang, Xi D.; Tobiasova, Zuzana; Taleb, Shakila A.; Liburd Jr, Samuel; Rodriguez, Leonel; Martins, Andrew J.; Flavell, Richard A.; Robert, Marie E.; Sefik, Esen; Pober, Jordan S.
  作者单位：Yale University; Yale University; University of Cambridge; Yale University; Yale University; Yale University; Howard Hughes Medical Institute
  摘要：We compared duodenal biopsies showing active celiac disease (CeD) to normal controls using single-cell RNA sequencing, cyclic immunofluorescence, RNAScope, and proximity ligation assays. There is increased infiltration of villous but not crypt epithelium T cells bearing either alpha f3 or gamma delta T cell receptors (TCRs) in CeD. Both T cell subsets are activated cytotoxic T lymphocytes (CTLs) and are the predominant mucosal source of IFN gamma. In response to this IFN gamma, villous but not...