6期

最新文章

• Identification of a stylet-secreted effector protein family as a core component of root-knot nematode feeding tubes AI翻译
  作者：Hussey, Richard S.; Mitchum, Melissa G.; Paul, Rebekah L.; Rocha, Raquel O.; Shields, John P.; Beamer, Lesa J.
  作者单位：University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; Connecticut Agricultural Experiment Station; University System of Georgia; University of Georgia; University of Missouri System; University of Missouri Columbia
  摘要：Proteins secreted from a mouth stylet of sedentary plant-parasitic root-knot nematodes self-polymerize to form a unique feeding tube structure within host cells modified into giant feeding cells by the nematode. Feeding tubes have essential functions as they complex with the host endomembrane system for nutrient uptake to sustain parasitism. Despite their significance, they remain one of the least understood aspects of nematode parasitism of plants. Their small size and location within giant-c...
• Hierarchical friction memory leads to subdiffusive configurational dynamics of fast-folding proteins AI翻译
  作者：Klimek, Anton; Dalton, Benjamin A.; Tepper, Lucas; Netz, Roland R.
  作者单位：Free University of Berlin
  摘要：Proteins often exhibit subdiffusive configurational dynamics, the origins of which are still unresolved. We investigate the impact of non-Markovian friction and the free-energy landscape on the dynamics of fast-folding proteins in terms of the mean squared displacement (MSD) and the mean first-passage-time (MFPT) of the folding reaction coordinate. We find the friction memory kernel from published molecular dynamics simulations to be well-described by a hierarchical multiexponential function, ...
• Probabilistic mapping and automated segmentation of human brainstem white matter bundles AI翻译
  作者：Olchanyi, Mark D.; Schreier, David R.; Li, Jian; Maffei, Chiara; Sorby-Adams, Annabel; Kinney, Hannah C.; Healy, Brian C.; Freeman, Holly J.; Shless, Jared; Destrieux, Christophe; Tregidgo, Henry; Iglesias, Juan Eugenio; Brown, Emery N.; Edlow, Brian L.
  作者单位：Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard T.H. Chan School of Public Health; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Tours; CHU Tours; University of London; University College London; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
  摘要：Brainstem white matter (WM) bundles are essential conduits for neural signals that modulate homeostasis and consciousness. Their architecture forms the anatomic basis for brainstem connectomics, subcortical circuit models, and deep brain navigation tools. However, their small size and complex morphology, compared to cerebral WM, makes mapping and segmentation challenging in neuroimaging. As a result, fundamental questions about brainstem modulation of human homeostasis and consciousness remain...
• Spatial transcriptomics reveals tumor microenvironment-driven subtypes of invasive lobular carcinoma AI翻译
  作者：Serra, Matteo; Rediti, Mattia; Collet, Laetitia; Lifrange, Frederic; Venet, David; Occelli, Nicola; Papagiannis, Andreas; Vincent, Delphine; Rouas, Ghizlane; Larsimont, Denis; Vikkula, Miikka; Duhoux, Francois P.; Rothe, Francoise; Sotiriou, Christos
  作者单位：Institut Jules Bordet; Universite Libre de Bruxelles; IFOM - FIRC Institute of Molecular Oncology; University of Liege; Institut Jules Bordet; Universite Catholique Louvain; Universite Libre de Bruxelles; Cliniques Universitaires Saint-Luc; Universite Catholique Louvain; Universite Catholique Louvain; Cliniques Universitaires Saint-Luc
  摘要：Invasive lobular carcinoma (ILC) is the second most common histological subtype of breast cancer and displays distinct clinical and biological behavior compared to breast cancer of no special type. However, current molecular classifications largely overlook its complex spatial organization and tumor microenvironment (TME). Here, we performed spatial transcriptomics on 43 hormone receptor-positive, HER2-negative (HR+/HER2-) ILC tumors with detailed morphological annotation and long-term clinica...
• Selective peroxynitrite-mediated protein nitration catalyzed by glyoxalase domain containing protein 4 AI翻译
  作者：Wright, Sarah; Dang, Vu C.; Hussain, Sami; Kandel, Prasanna; Brendza, Robert P.; Mazhar, Sahar; Whitmore, Marie; Boudoukha, Selim; Banwait, Jaskamaljot Kaur; Van Der Linden, Robert; Vertudes, Edward; Markham, Kate; Trzeciak, Marta; Pohan, Grace; Jennings, Andy; -Latham, Sheerin Shahidi; Kayser, Frank; Beckstead, Mike; Lucius, Aaron L.; Kashyapa, Arun; Ischiropoulosd, Harry; Griswold-Prenner, Irene
  作者单位：University of Alabama System; University of Alabama Birmingham; Oklahoma Medical Research Foundation; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania
  摘要：Tyrosine nitration alters the structure, function, and cellular localization of proteins and is implicated in the pathology of multiple diseases [G. Ferrer-Sueta et al., Chem. Rev. 118, 1338-1408 (2018), H. Ischiropoulos, Arch. Biochem. Biophys. 356, 1-11 (1998), I. Griswold-Prenner etal.,J. Biol. Chem. 299, 105038-10554 (2023)]. Although protein nitration is assumed to proceed via nonspecific chemical mechanisms, it is highly selective, suggesting the possibility of enzymatic catalysis. Here,...
• Diets, dominance hierarchies, and kleptoparasitism drive asymmetrical interactions between wolves and cougars AI翻译
  作者：Binder, Wesley; Ruprecht, Joel S.; Rabe, Jack; Metz, Matthew C.; Hutchinson, Rebecca; Stahler, Daniel R.; Levi, Taal
  作者单位：Oregon State University; University of Minnesota System; University of Minnesota Twin Cities; Oregon State University
  摘要：After widespread extirpation, conservation efforts have restored large carnivores to portions of their former range. Substantial research has since focused on their ability to alter ecological communities through effects on herbivores and mesocarnivores, but the principles governing competition among multiple apex carnivores remain unclear. While mesocarnivore scavenging of apex carnivore kills drive enemies with benefits dynamics, subordinate apex carnivores seldom rely on scavenging. Instead...
• Variable thresholds for phosphorylation targets of the ERK signaling pathway AI翻译
  作者：Hayashi, Kristyn; Sekaran, Suganya; Simpson, Pelle; Ebmeier, Christopher C.; Michel, Cole R.; Ahn, Natalie G.
  作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; Children's Hospital Colorado; University of Colorado Anschutz
  摘要：Cell fates regulated by ERK respond to different thresholds of signaling strength. In mammalian cells, conditions that activate ERK to submaximal levels are sufficient to sustain proliferation, survival, and transformation, while stimuli that activate ERK to very high levels often lead to cell death or cell cycle arrest. But while this Goldilocks effect is well known, the mechanisms have never been fully explained. In particular, threshold responses have been shown at the level of transcriptio...
• Structural analysis of rhodopsin states in megabody complexes AI翻译
  作者：Salom, David; Suder, Diana S.; Huang, Wei; Wu, Arum; Pardon, Els; Steyaert, Jan; Kiser, Philip D.; Taylor, Derek J.; Gonen, Shane; Palczewski, Krzysztof
  作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; University System of Ohio; Case Western Reserve University; Vrije Universiteit Brussel; Flanders Institute for Biotechnology (VIB); Vrije Universiteit Brussel; University of California System; University of California Irvine; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Long Beach Healthcare System; University of California System; University of California Irvine; University of California System; University of California Irvine
  摘要：Rhodopsin, the most intensively studied G protein-coupled receptor (GPCR), is activated by light-induced isomerization of its chromophore 11-cis-retinal. This study employed cryogenic electron microscopy (cryo-EM) to investigate rhodopsin structure using a megabody (Mb7) as a negative allosteric modulator. Three distinct cryo-EM structures were solved: ground-state rhodopsin, photoactivated rhodopsin, and apo-rhodopsin, all in complex with Mb7. Photoactivated rhodopsin and apo-rhodopsin, both ...
• PTP1B inhibition promotes microglial phagocytosis in Alzheimer's disease models by enhancing SYK signaling AI翻译
  作者：Cen, Yuxin; Alves, Steven R.; Song, Dongyan; Felice, Christy; Preall, Jonathan B.; Van Aelst, Linda; Tonks, Nicholas K.
  作者单位：Cold Spring Harbor Laboratory; State University of New York (SUNY) System; Stony Brook University; University of Texas System; UTMD Anderson Cancer Center
  摘要：Amyloid f3 (Af3) accumulation is a hallmark of Alzheimer's disease (AD). Emerging evidence suggests that impaired microglial Af3 phagocytosis is a key feature in AD, highlighting the therapeutic potential of enhancing this innate immune function. Here, we demonstrate that genetic deletion or pharmacological inhibition of protein tyrosine phosphatase 1B (PTP1B) ameliorated memory deficits and reduced Af3 burden in APP/ PS1 mice. Moreover, we show that PTP1B was highly expressed in microglia, an...
• Health-focused frames mobilize Americans to action to address LGBTQ AI翻译
  作者：Dietze, Pia; Brown, Riana M.; Craig, Maureen A.
  作者单位：University of California System; University of California Irvine; University System of Ohio; Ohio State University; Duke University
  摘要：More than 1 in 8 LGBTQ people live in states where doctors can refuse to treat them. This headline describes a flurry of laws passed in 2025 allowing doctors to refuse treatment of LGBTQ patients based on personal beliefs. This and other laws like it limit healthcare access and exacerbate health inequality for LGBTQ individuals. But health is not the only domain in which LGBTQ individuals face disparities. Long-standing inequalities also exist in other domains of life, for example, gay men ear...