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作者：Song, Yahui; Huang, Xuege; Wei, Lin; Shen, Wenwen; Gao, Jiapeng; Hou, Kai; Yang, Bin; Wang, Yi; Hu, Guang; Xu, Wei; Guo, Jing; Lin, Wenlong; Li, Min
作者单位：Soochow University - China; Soochow University - China; Anhui Medical University; Kunming University of Science & Technology; Soochow University - China; Stanford Medicine; Stanford University; Zhejiang University
摘要：Myocarditis is a potentially fatal disease that can progress to inflammatory dilated cardiomyopathy (DCMi), a condition that is a leading cause of noncongenital heart failure in young adults. However, the mechanisms driving the transition from acute myocarditis to DCMi remain poorly understood. Although IL-17A-mediated inflammation is a well-known driver of this progression, the intracellular regulators that sustain and amplify this response remain unclear. Here, we identify the E3 ubiquitin l...
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作者：Tan, Taicong; Zhao, Yanan; Chen, Yinghong; Mi, Yali; Zeng, Jiaxin; Du, Peng; Han, Tingting; Liu, Yawen; Li, Ning; Kong, Jun; Wang, Liying; Yu, Yang; Li, Mulin Jun; Zhang, Liangran; Li, Wei; Liu, Chao
作者单位：Guangzhou Medical University; Shandong Normal University
摘要：Proper crossover (CO) formation in meiosis serves dual roles in ensuring accurate chromosome segregation and generating genetic diversity. However, the molecular mechanisms underlying CO number and distribution remain incompletely understood. Previous studies have implicated the ubiquitin-proteasome system in CO regulation, but specific regulators and mechanisms are poorly defined. Here, we identify the E3 ubiquitin ligase Ufd2p as a key regulator promoting efficient CO formation through a foc...
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作者：Hu, Yue; Gruen, Jeffrey R.; Zhang, Heping
作者单位：Yale University; Yale University
摘要：Depression is shaped by both genetic and environmental factors, but genome-wide interaction studies (GWIS) often lack power to detect complex gene-environment (G & times; E) interactions. We applied a forest-based machine learning approach to 38,018 UK Biobank (UKB) participants, examining interactions between 285,677 single-nucleotide polymorphisms (SNPs) and three trauma types (childhood, adult, and catastrophic trauma). While GWIS detected no significant interactions, we identified 8,225 po...
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作者：Li, Chenghan; Chan, Garnet Kin-Lic
作者单位：California Institute of Technology; California Institute of Technology
摘要：Obtaining the free energies of condensed phase chemical reactions remains computationally prohibitive for high-level quantum mechanical methods. We introduce a hierarchical machine learning framework that bridges this gap by distilling knowledge from a small number of high-fidelity quantum calculations into increasingly coarse-grained, machine-learned quantum Hamiltonians. By retaining explicit electronic degrees of freedom, our approach further enables a faithful embedding of quantum and clas...
