Neurotensin in the extended amygdala maintains wakefulness in novel environments
成果类型：
Article
署名作者：
Hung, Chi Jung; Ueda, Shuhei; Rahaman, Sheikh Mizanur; Yamamoto, Mikiyasu; Li, Jiahui; Fukatsu, Noriaki; Bito, Haruhiko; Yamaguchi, Hiroshi; Yamanaka, Akihiro; Takemoto-Kimura, Sayaka; Ono, Daisuke
署名单位：
Nagoya University; Nagoya University; Nagoya University; Nagoya University; Nagoya University; University of Tokyo; National Institutes of Natural Sciences (NINS) - Japan; National Institute for Physiological Sciences (NIPS); Chinese Institute for Brain Research, Beijing
刊物名称：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN/ISSBN：
0027-8424; 1091-6490
DOI：
10.1073/pnas.2521268123
发表日期：
2026-02-10
页码：
e2521268123
关键词：
neurotensin
wakefulness
novel environments
interstitial nucleus of the posterior limb of the anterior commissure
substantia nigra
SLEEP-DEPRIVATION
rat-brain
neurons
nucleus
stress
adaptation
expression
receptors
gaba
mice
摘要：
Animals remain awake in unfamiliar environments to assess potential safety threats, a process involving changes in neuronal activity within sleep-wake regulatory brain regions. However, the specific circuits and neurotransmitters involved remain poorly understood. Here, we show that neurotensin (NTS) peptides in corticotropin-releasing factor (CRF) neurons of the lateral part of the interstitial nucleus of the posterior limb of the anterior commissure (IPACL) play a key role in maintaining wakefulness in response to environmental changes. Activation of IPACL(CRF) neurons increased wakefulness, whereas their inhibition or deletion of NTS reduced wakefulness in novel environments. These neurons are activated in response to exposure to a novel environment and project primarily to the substantia nigra pars reticulata (SNr) and release NTS, which modulates wakefulness. These findings suggest that NTS signaling from IPACL(CRF) neurons to the SNr is essential for sustaining wakefulness in unfamiliar or changing environments.
来源URL：